The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

🚨 New preprint: Objective Quality Assessment for Precision fMRI

Precision functional mapping (PFM) enables individual-level brain network studies — but demands more, and better, data.

We introduce an objective framework to determine when a dataset truly supports interpretable, replicable PFM.

In light of Sim saying that he said Orr dealt drugs based on seeing a mystery photo from a mystery person, I think it’s important to reflag this.

If this is an uncharitable interpretation, the mayor is free to provide more details of how he ended up seeing such a photo and believing it.

I am recruiting a new graduate student for September. Comp neuroscience type approaches, definitely fmri based. Possible specific topics include dense longitudinal scanning in psychosis, or the effects of psilocybin on brain function in depression.

Look me up and send me an email if interested.

German Jews were citizens of Germany at the start of 1933. By the end of 1933, the Nazis had
removed citizenship from naturalized citizen Jews.

In 1935, all German Jews were fully stripped of their German citizenship.

Citizenship under dictatorships is contingent for targeted minorities.

Considering brain state for individualized functional connectivity-based rTMS Abstract. Recent endeavors to optimize the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) treatment have focused on locating individualized stimulation targets using functional connec...

Controversial? Classic?
What if rest is not best? 🤔
Congrats to @halleeshearer.bsky.social for this thoughtful commentary, and thanks to @ninetlab.bsky.social for the 🎬 movie x rTMS 🧲 collaboration. doi.org/10.1162/IMAG...

So cool!! Great work Hallee 😮🤩

Worth noting that because Sim brought forward his proposal for a property tax freeze requiring millions in cuts with just weeks left in the budget process, this is not up for public debate and is not outlined in the documents available to councillors when they vote on this

Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.

Over 40% of brain-behavior effects were likely overestimated due to motion. There was no correlation between a trait’s a priori correlation with motion and its motion overestimation score. Calculating the motion impact score was necessary to discover the problematic brain-behavior effects!

#eNeuro | Depression Levels Are Associated with Reduced Capacity to Learn to Actively Avoid Aversive Events in Young Adults
https://doi.org/10.1523/ENEURO.0034-25.2025

Hi #canadian researchers - please sign this petition to help ensure funding isn’t cut to tri council agencies (NSERC, SSHRC, and CIHR). We’re looking at potential 15% cuts to ALL federal spending including grants win.newmode.net/canadianasso...

Draw the Line: Tell the Carney Government to Pick a Side | The Tyee For people, for peace, for the planet. An invitation to join the Sept. 20 mass day of action.

A public invite to the Sept 20 Draw the Line actions from 21 movement leaders - representing an amazing cross-section of organizations.

Find the action closest to you.

Draw the Line: Tell the Carney Government to Pick a Side via @thetyee.ca thetyee.ca/Opinion/2025...

Research links Canada’s fossil fuel industry to deadly heat waves Emissions from fossil fuel and cement companies have contributed significantly to the frequency and severity of devastating heat waves over the last two decades, a new study finds. The paper could hel...

New research published in Nature draws a direct link between high-emitting fossil fuel and cement companies and the frequency and severity of heat waves, including the 2021 heat dome that caused 619 deaths in BC www.nationalobserver.com/2025/09/10/n...

'Massive' wildfire south of Port Alberni, B.C., doubles in size Tuesday | CBC News The Mount Underwood fire near Port Alberni, B.C., has more than doubled in size in less than a day, growing to almost 1,400 hectares Tuesday, and knocking out power for more than 500 B.C. Hydro customers.

Let’s be clear about the wildfires - endless logging and fossil fuel expansion have made this situation worse.

It's shameful to see politicians pushing for the expansion of logging and fossil fuels as we experience and witness this devastation. #wildfires #cdnpoli
www.cbc.ca/news/canada/...

I still get chills

Meet Mike
*30+ years severe depression
*first hospitalized @ 13y
*20 meds
*3 rounds of ECT
*2 near-fatal suicide attempts

Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE

see videos, read paper, follow thread
doi.org/10.31234/osf...

Kids in Pennsylvania Are Breathing (Much) Easier After a Coal Plant Shuttered - Inside Climate News Pediatric asthma ER visits dropped 40 percent after a coal processing plant near Pittsburgh closed down, researchers found.

“I think the best word is validation”: Residents react to research showing immediate health improvements after the closure of a coal processing plant.

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...

'No Other Land' Contributor Odeh Hadalin Killed in West Bank Settler Attack Odeh Hadalin, a contributor to the Oscar-winning documentary 'No Other Land,' was reportedly killed in an attack by Israeli settlers in the West Bank.

Palestinian activist Odeh Hadalin (a.k.a. Awdah Hathaleen), who was featured in the Oscar-winning documentary No Other Land, was shot to death in the West Bank on Monday.

6/ Indeed, to achieve high prediction performance, 10-min scans are cost inefficient. In most scenarios, the optimal scan time is ≥20 min. On average, 30-min scans are the most cost effective, yielding 22% savings over 10 min scans. Overshooting is cheaper than undershooting ...

American Dachau: Trump Takes the Next Step Six months.

Alligator Alcatraz is the American Dachau. The first concentration camp. The Nazis initially portrayed Dachau as a proper prison with proper treatment.
Trump prefers to promote the cruelty and barbarism.
This is my latest on where this goes next.

charlieangus.substack.com/p/american-d...

"Dr. Kobak and his team calculate that at least 13.5 percent of all biomedical abstracts appeared to have been written with the help of chatbots."

Not so surprising, given tools like Writefull (now integrated into Overleaf) that are explicitly marketed to scientists for this purpose.

Discovering cognitive strategies with tiny recurrent neural networks - Nature Modelling biological decision-making with tiny recurrent neural networks enables more accurate predictions of animal choices than classical cognitive models and offers insights into the underlying cog...

Thrilled to see our TinyRNN paper in @nature! We show how tiny RNNs predict choices of individual subjects accurately while staying fully interpretable. This approach can transform how we model cognitive processes in both healthy and disordered decisions. doi.org/10.1038/s415...

Graphs showing 25 years of budgets for the National Institute of Health, NASA, and the NSF. In all cases, the proposed budget for next year is far, far below any year of the previous quarter century.

There are 2 previous historical cases of countries destroying their science and universities, crippling them for decades: Lysenkoism in the USSR and Nazi Germany. The Trump administration will be the 3rd.
It's not just budgets but research, institutions, expertise, and training the next generation.

White House MAHA Report may have garbled science by using AI, experts say The report, led by Health and Human Services Secretary Robert F. Kennedy Jr., was intended to address the reasons for the decline in Americans’ life expectancy.

NEW: Citations in the MAHA Report have telltale signs of AI chatbot use -- we reviewed all 522 of the listed citations, and at least 37 of the footnotes appear multiple times in the citations with another 21 having dead links

w/ @laurenweberhp.bsky.social

www.washingtonpost.com/health/2025/...

Imaging a concussion and the ensuing immune response at the blood–brain barrier | PNAS Concussions can cause debilitating symptoms despite no evidence of structural changes on diagnostic imaging. The cellular events occurring in the b...

Imaging a concussion and the ensuing immune response at the blood–brain barrier | PNAS www.pnas.org/doi/10.1073/...

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

1. Over the past four months I've talked with many foundation directors about science philanthropy during Trump 2.0.

Two things come to the fore every time.

i) The most important they can do is maintain the pipeline of talent

ii) With the federal govt pulling out, ROI is higher now than ever.

Ontario hospitals spent more than $9-billion on agency staff over 10 years, study finds The Canadian Centre for Policy Alternatives study found that from 2013-14 to 2022-23 public hospital spending on staff increased 6%, but their spending on private agencies increased 98%

Ontario hospitals spent more than $9-billion on nurses and other staff from for-profit agencies in a 10-year period, a new study concludes, by Allison Jones www.theglobeandmail.com/canada/artic... via @theglobeandmail.com @policyalternatives.ca

Telus Health prepares to stand alone after years of acquisitions Over nearly two decades, Telus Health has grown into a multiheaded player with an outsized presence in Canada’s health care system

From side hustle to vertically integrated for-profit care, we should all be paying attention to what’s happening at Telus Health…

…and what that means for the future of primary care.

Well reported piece by @hannay.bsky.social.

www.theglobeandmail.com/business/eco...