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Posts by Raphael Brito

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How do social netowrks form and evolve? We looked at a bunch of bats to explore this!
doi.org/10.1111/nyas...

1 week ago 15 5 1 0

NAC coding for distance to goal is dependant on VTA's dopamine, but not HPC or PFC activity. Really cool stuff from the Ito group!

1 week ago 1 0 0 0
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Dorsoventral hippocampus neural assemblies reactivate during sleep following an aversive experience - Nature Neuroscience Synchronization of sharp-wave ripples across the dorsoventral hippocampus during sleep supports coordinated reactivation that represents negative experiences more faithfully than positive ones.

Our paper is out today!!! (not an April fool's day joke) Congrats to authors @azulsilva.bsky.social, @belalima-paiva.bsky.social, Ele Pronier, and mostly to the amazing scientist and human being who led this project @facuumm.bsky.social
#neuroskyence #hippocampus
www.nature.com/articles/s41...

2 weeks ago 75 30 11 1
Entorhinal cortex represents task-relevant remote locations independently of CA1 - Nature Neuroscience Neurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations ar...

My main postdoc work is now published: www.nature.com/articles/s41...! We (myself, Isabel Low, Frances Cho, and @lgiocomo.bsky.social) discovered task-relevant remote representations in entorhinal cortex independent of CA1. #paperthread below! 1/13

2 weeks ago 69 27 6 1

🔔PREPRINT: Sleep ripples drive single-neuron reactivation for human memory consolidation
1/9: How does sleep support human memory consolidation? To test this, we recorded hundreds of neurons in the human medial temporal lobe (MTL) across learning, wakefulness, and sleep.
doi.org/10.64898/202...

2 weeks ago 42 26 1 1

Astounding work!
I don't know much about subiculum but do we know, or can you speculate on the interaction between HPC CA1 Sharp wave ripples and these plateau you describe? We know SWR occur more at reward, could they be driving these "low" plateaus?

2 months ago 1 0 1 0

🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome!

www.biorxiv.org/content/10.6...

2 months ago 44 22 2 0
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Astrocytes enable amygdala neural representations supporting memory - Nature Astrocytes in the basolateral amygdala dynamically track fear state and support fear memory retrieval and extinction.

Really nice work from the Holmes lab looking at amygdala astrocytes in fear memory and extinction!

www.nature.com/articles/s41...

2 months ago 35 14 0 2
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Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals Nature Neuroscience - Bergel et al. show that an infraslow rhythm connecting the brain and body during sleep is shared by lizards, mammals and birds, revealing an ancestral process and reshaping...

⚠️ New paper alert and what a way to end 2025! 🎉
Happy to share our story “Sleep-dependent infraslow rhythms are evolutionarily conserved across reptiles and mammals.” published today in Nature Neuroscience.

Sleeping dragons 🦎 and functional ultrasound!
Read the full paper here: rdcu.be/eWJHb 1/8

3 months ago 101 37 3 2
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I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !

With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics

6 months ago 71 28 4 1
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🚨 New preprint! 🚨

Excited and proud (& a little nervous 😅) to share our latest work on the importance of #theta-timescale spiking during #locomotion in #learning. If you care about how organisms learn, buckle up. 🧵👇

📄 www.biorxiv.org/content/10.1...
💻 code + data 🔗 below 🤩

#neuroskyence

7 months ago 135 58 10 6
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Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells - Nature Neuroscience Using a virtual reality apparatus in rats that dissociates external landmarks from self-motion cues, the authors describe how the two modes of theta phase coding in the hippocampus during navigation a...

Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells

www.nature.com/articles/s41...

7 months ago 22 4 0 1
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Cooperative actions of interneuron families support the hippocampal spatial code Identifying the computational roles of different neuron families is crucial for understanding neural networks. Most neural diversity is embodied in various types of γ-aminobutyric acid–mediated (GABAe...

Cool new findings on interneurons and spatial coding. Nice!
www.science.org/doi/10.1126/...

7 months ago 8 2 0 0
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Excited to share our new preprint on the brain-wide organization of intrinsic timescales at single neuron resolution. Work w/ @roxana-zeraati.bsky.social, @intlbrainlab.bsky.social, Anna Levina, @engeltatiana.bsky.social : www.biorxiv.org/content/10.1...

7 months ago 55 24 2 2
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🧠 Are you an early-career brain science researcher interested to attend #FENS2026 in Barcelona, Europe’s largest #neuroscience meeting? Apply for the ALBA-CHS Travel Awards!

✈️ Tiered grants for EU & non-EU candidates
✅ Final-year PhD/MD or ≤10 years post-PhD/MD
👉🏽 loom.ly/7FOgCJc
📆 21 Oct 2025

7 months ago 8 11 1 3

Thanks, that explains a lot of things!

7 months ago 1 0 0 0
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Could it be that photometry averages two different populations, one that is responding to reward onset, one that increase at CS+ time? (Somehow remind me of this paper pmc.ncbi.nlm.nih.gov/articles/PMC...) Or did I just misread the old papers?

7 months ago 1 0 1 0
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Very cool data! Congrats! I have so many questions!
First one that pop to my mind: I'm suprised to see that DA and GABA neurons keep firing at the reward time, even during 'late' phase. My understanding of classical Schultz results were that the response to reward faded away with learning?

7 months ago 2 0 2 0

Very excited to share this major update to our paper delineating VTA GABA neuron encoding of valence and decision conflict. Studies led by the amazing @margestelzner.bsky.social. We leaned in here, taking the opportunity to add a lot of cool new data. www.biorxiv.org/content/10.1...

7 months ago 50 16 2 2
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Corticotropin-releasing hormone modulates NREM sleep consolidation through the thalamic reticular nucleus Nature Communications - Corticotropin-releasing hormone (CRH), known for activating the HPA axis during stress, also acts centrally in the brain. Here, the authors show that CRH modulates thalamic...

Happy to announce our new paper in Nature Communications: rdcu.be/eBpGY
We show how CRH in the thalamic reticular nucleus modulates NREM sleep, helping to understand how stress impacts sleep

Congrats to Loredana Cumpana and team, in work led by Simone Astori!
@epfl-brainmind.bsky.social‬

8 months ago 88 23 4 1

Ps: Does anyone know of a project to translate this in French?
I have a lot of relatives that could be very interested, but don't necessarily have the English fluency to grasp everything.
I'd be happy to help!

8 months ago 0 0 0 0

The authors that I found on bluesky:
@lewan.bsky.social @karmaos.bsky.social @noupside.bsky.social @karmaos.bsky.social @philippmarkolin.bsky.social @chrischirp.bsky.social @johnfocook.bsky.social
Thanks for the great work !

8 months ago 3 0 0 0
The Anti-Autocracy Handbook: A Scholars' Guide to Navigating Democratic Backsliding The Anti-Autocracy Handbook is a call to action, resilience, and collective defence of democracy, truth, and academic freedom in the face of mounting authoritarianism. It tries to provide guidance to ...

In these dark times for Science and Democracy, it's alleviating and refreshing to read solution-driven, high-quality academic work on the subject of Democratic Backsliding.

zenodo.org/records/1569...

8 months ago 7 4 3 0

"The lack of full-bodied locomotion and extensive exploratory behaviors in head-fixed paradigms indicates that in our experimental setup the behavioral state is not directly analogous to the preparatory and consummatory phases seen in freely moving tasks."

8 months ago 1 0 0 0
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Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning Social learning enables a subject to make decisions by observing the actions of another. How neural circuits acquire relevant information during observation to guide subsequent behavior is unknown. Ut...

Mirror neurons making a comeback?

8 months ago 7 1 0 0
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Remote activation of place codes by gaze in a highly visual animal - Nature Place cells in the chickadee hippocampus coherently represent locations in space, whether physically visited or viewed, enabling spatial reasoning at a distance through a unified process coordinated b...

Remote activation of place codes by gaze in a highly visual animal www.nature.com/articles/s41... - very cool study with chickadees!

8 months ago 34 8 0 0
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Connectomic reconstruction from hippocampal CA3 reveals spatially graded mossy fiber inputs and selective feedforward inhibition to pyramidal cells The mossy fiber (MF) connections to pyramidal cells in hippocampal CA3 are hypothesized to participate in pattern separation and memory encoding, yet no large–scale neuronal wiring diagram exists for ...

Really beautiful hippocampal connectomics from @zhihaozheng.bsky.social et al. Such high quality data shows many interesting circuit wiring surprises - an incredible resource to digest! Great also to see the parallels with our physiology work on neuronal heterogeneity
www.biorxiv.org/content/10.1...

9 months ago 6 3 0 0
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Representation of sex-specific social memory in ventral CA1 neurons Recognizing familiar individuals is crucial for adaptive social interactions among animals. However, the multidimensional nature of social memory encompassing sexual information remains unelucidated. ...

I haven't seen this one pop in my feed but I find it super interestingl!

www.science.org/doi/10.1126/...

9 months ago 2 1 0 0

Very impressive work!

9 months ago 2 0 0 0
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Discrete spatiotemporal encoding of striatal dopamine transmission Dopamine (DA) transmission critically regulates diverse, basal ganglia–dependent behaviors by activating distinct subtypes of G protein–coupled receptors. Spatially broad DA release has been extensive...

Very cool work from Chris Ford's group out in @science.org

9 months ago 4 2 0 1