Decoding the Dark Peptidome – Svensson Lab, Stanford University YouTube video by WebsEdgeMedicine

Grateful to the American Diabetes Association @amdiabetesassn.bsky.social for the opportunity to make a short film about our lab at Stanford University. We talk about peptides and their roles in metabolic health.

youtu.be/qUjYPTN09mI?...

See you at ADA 2025 in Chicago

Understanding peptide hormones: from precursor proteins to bioactive molecules Peptide hormones are fundamental regulators of biological processes involved in homeostasis regulation and are often dysregulated in endocrine disease…

Sharing our latest review on peptide hormones in Trends in Biochemical Sciences

Free full text here:

www.sciencedirect.com/science/arti...

Thank you!

Thanks Enrique!

Thank you Katsu!

Thank you!

This work would not have been possible without the amazing work of Laetitia Coassolo @Laeti67202 , Niels Danneskiold @nbds_bio and our collaborators Danny Chou, Liqun Luo, Andreas Stahl at UCBerkeley and many others! Thanks to NIDDK, American Heart Association SPARK Stanford Pathology @StanfordCVI

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide - Nature Computational drug discovery is used to identify a 12-mer peptide derived from BRINP2 with potent anti-obesity effects that are independent of leptin, glucagon-like peptide 1 receptor and melanocortin...

Today in @Nature, we share our latest paper. We developed an algorithm to predict novel peptides cleaved by proconvertases across all human tissues. Using this method, we identified BRP, a brain-derived anti-obesity peptide 🧠

www.nature.com/articles/s41...

Cooperative nutrient scavenging is an evolutionary advantage in cancer - Nature Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.

new out in Nature www.nature.com/articles/s41...

CD45-PET is a robust, non-invasive tool for imaging inflammation - Nature A non-invasive in vivo positron emission tomography imaging approach detects inflammatory disease using various preclinical models.

This is cool. CD45–PET for imaging inflammation

www.nature.com/articles/s41...

Congratulations to Zeyuan for winning the travel prize! Thank you LifeMetabolism for supporting his work!

New research from the lab of Institute Scholar Jonathan Z. Long, led by first author María Dolores Moya Garzón, identifies a new metabolic pathway that helps explain the molecular links between ketogenic diets and body weight regulation.

#YearInReview A new understanding of how ketosis is linked to body weight regulation: https://buff.ly/3ZOkoId

An important discussion for sure!

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AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors Secreted proteins play crucial roles in paracrine and endocrine signaling; however, identifying ligand-receptor interactions remains challenging. Here…

www.sciencedirect.com/science/arti...

Sharing our receng paper in Cell Systems that demonstrates how AlphaFold can predict the binding between ligands and cell surface receptors. Congrats Niels and co-authors from K.C. Garcia lab
#alphafold
See paper here: cell.com/cell-systems/a…

Stochastic neuropeptide signals compete to calibrate the rate of satiation Nature - Release of hunger-promoting and satiety-promoting neuropeptides drives opposing changes in the second messenger cAMP in awake mouse paraventricular hypothalamic MC4R neurons, thereby...

Stephen Zhang and the team found that in vivo peptide release and signaling gradually enhances responses of satiety-promoting hypothalamic neurons to each bite of food. These consequences of each bite take minutes to manifest, and could help explain why slow eating enhances satiety. rdcu.be/dZlI3

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