Who knew the YAK could hold the secret to healing the human brain? (Hint - gene is Retsat) Source: www.the-scientist.com/a-genetic-mutation-found...

A new Scn8a R1872W mouse model is paving the way for CRISPR-based epilepsy treatments. Source: https://www.jci.org/articles/view/196402

New research explores a promising, low-toxicity transplant strategy for diabetes. Learn more: https://www.jci.org/articles/view/201105#SEC7 And to view diabetic specific models, visit: www.mmrrc.org/catalog/StrainCatalogSea...

When global competitors are accelerating their investments in biomedical research, America cannot afford to fall behind...www.fiercebiotech.com/research/despite-delays-...

Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome. Read More Here: https://postly.click/5vU

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

Scientists, with initial mouse models findings, expand results in organoids to confirm nerve-repair treatment can trigger healing in human spinal tissue. Source: www.sciencealert.com/scientists-grew-mini-hum...

🫱A new polymer delivery system may allow insulin to be absorbed through the skin and control blood sugar without injections, at least in animal studies! Source: https://www.nature.com/articles/s41586-025-09729-x

In vivo & in silico: Compounds linked to traditional medicine reduced anxiety-, depression-, and pain-related behaviors in mice. Computer modeling suggested key compounds and targets, while mouse studies showed how those predictions played out biologically: https://doi.org/10.100

Turning Back Immune System Aging: A new method instructs liver to pump out specific proteins, effectively hitting the "reset" button on an aging immune system to restore youthful defense capabilities. Source: www.livescience.com/health/immun...

📖 To celebrate the holidays, we've taken some of our strains to compose a seasonal story. Written version is below. Or spoken version here: youtu.be/xl-pHB0Y5bc . For the full "cast" see this link: postly.click/s61

National Security Commission on Emerging Biotechnology warns U.S. science is getting outpaced: www.fiercebiotech.com/biotech/us-commission-re...

Scientists found that HSL not only breaks down fat but also works inside the nucleus of to keep adipose tissue healthy, explaining why people lacking HSL lose fat instead of becoming obese. https://scitechdaily.com/obesity-discovery-

The research landscape is approaching a turning point. Proposed cuts would weaken science—especially physiology—that drives medical breakthroughs. This overview sets the stage for a deeper look at what’s at stake and why this full report matters: https://www.physio

The FDA has approved Kygevvi (doxecitine + doxribtimine) as the first-ever treatment for Thymidine Kinase 2 Deficiency (TK2d), offering hope to patients with this devastating mitochondrial disease. www.fda.gov/drugs/news-events-human-...

Scientists have made major progress in understanding and treating thymidine kinase 2 deficiency (TK2d), a rare genetic disorder that weakens muscles by disrupting mitochondrial DNA maintenance. https://postly.click/ABY

James D. Watson, part of the team that uncovered the double-helix structure of DNA in 1953 with Francis Crick, Rosalind Franklin and Maurice Wilkins, has died at 97. His work marked a notable moment in biology.
www.yahoo.com/news/articles/james-wats...

As oocytes grow, H2A.Z shifts from marking active genes to spreading across broader, silent DNA regions, working hand-in-hand with another modification to support healthy meiosis and prepare the egg’s epigenetic blueprint for early embryonic life. .nature.com/articles/s41594-025-01573-xMore Info:

IMPC Strategic Conference
‘Insights from the Past, Shaping the Future’

Program and key information
👉 www.mousephenotype.org/news/2025-virtual-impc-c...

Free Registration
👉https://tinyurl.com/yz7znkde

🎉 Big congrats to Dr. Eric Green for receiving the American Society of Human Genetics Leadership Award — a standing ovation for visionary leadership in genomics! Read About it here: www.genengnews.com/topics/omics/eric-green-...

"Animal models provide insights that alternative approaches can’t. A heated debate about which method is better is distracting researchers from doing good science."

https://EcKc5wILd4%3D

MMRRC is in Boston at ASHG for the next 3 days - booth 1327! For more info: https://meetings.ashg.org/event/ASHG25/program/schedule

What Baby KJ’s CRISPR Breakthrough Really Tells Us. Reflections on the balance between hope and realism — new therapies are exciting, but they’re not universal cures yet. Read More: www.statnews.com/2025/10/09/crispr-cure-b...

Congratulations to Drs. Brunkow, Ramsdell, & Sakaguchi! For More information: https://postly.click/ECH

“...the first step out of the maze for young men begins by reasserting to them the virtue of hard work — an often grueling but indispensable part of finding the right answers in science.”

Read the essay with our gift article here: www.nytimes.com/2025/10/03/o...

Some good research "food for thought... " www.nature.com/articles/d41586-025-0292...

🌟 We’re proud to support the Rare Diseases Are Not Rare! Challenge—working together for faster treatments.
With over 10,000 rare diseases, collaboration is key to speeding discovery and care. Learn more: www.challenge.gov/

We're taking efforts to improve the information of new strains at the MMRRC, with our new Strain Quality Control. To view an example of one, visit this strain: www.mmrrc.org/catalog/sds.php

" Read more here: www.genengnews.com/topics/translational-med...

"To be clear, there is no replacement yet for animal research in biomedical science...it remains to be seen how faithfully these [stem cell] reprogrammed cells and organoids mimic various complex biological processes.