Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates Liu et al. identify that an iron-triggered aging pathway, termed ferro-aging, is orchestrated by ACSL4. Vitamin C directly targets and inhibits ACSL4, thereby blocking ferro-aging. Their further resea...

Vitamin C inhibits ACSL4 to alleviate ferro-aging in primates: Cell Metabolism www.cell.com/cell-metabol...

I’m a Nobel Prize-winning immigrant. I can no longer recognize this country. Attacks on science and immigrants are destroying America.

Nobel Laureate Jack Szostak “This country has given me endless opportunities…: The America we inhabit today bears almost no resemblance to the country I chose all those years ago” newsletter.ofthebrave.org/p/im-a-nobel...

Luminal surface proteome of the brain vasculature uncovers blood-brain barrier regulators At the blood-tissue interface, vasculature luminal surface is critical for molecular transport, signaling transduction, and cell extravasation. Here, we present a method for proteomic profiling of the vasculature luminal surface in vivo, broadly ...

Luminal surface proteome of the brain vasculature uncovers blood-brain barrier regulators | Science www.science.org/doi/10.1126/...

And here’s the eclipse photo from Artemis II. I am in tears.

Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar Over the last three decades, dogma-breaking studies have refuted the brain’s assumed immune isolation. Echoing Ramón y Cajal metaphor of neurons as “butterflies,” Schwartz proposes viewing the brain a...

Evolving brain-immunity: From Ramón y Cajal’s mysterious butterflies to a garden sustained by immune cells as their nectar: Neuron www.cell.com/neuron/fullt...

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial...

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature: Cell www.cell.com/cell/fulltex...

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition Delivanoglou et al. show that expression of APOE4, a risk factor for Alzheimer’s disease, leads to sexually dimorphic lymphatic and inflammatory responses in mice and humans alike. Suppressing APOE4-i...

Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition: Neuron www.cell.com/neuron/fullt...

All the love to you, Rebecca ❤️

2026 Midwest Zebrafish Meeting Join us for 2026 Midwest Zebrafish Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.

Dear fish lovers, don’t forget to mark your calendars!

The Midwest Zebrafish Meeting is coming to the Van Andel Institute in Grand Rapids, MI, this summer (June 24–26).

We’d love to hear about your research, so come share what you’ve been working on!

www.vai.org/event/2026-m...

Figure: Organ dysfunctions in sepsis. Created in BioRender. Singer, M (2025) https://BioRender.com/l1o1l55. ARDS=acute respiratory distress syndrome. Copyright: Elsevier Ltd. All rights are reserved.

Sepsis is a serious condition where the body’s response to an infection becomes out of control and starts to damage its own organs.

A Seminar explores the complexity of the condition, and discusses current challenges and future developments in care: spkl.io/63325ALSAl

It's out! Happy to present ITEC, a semi supervised algorithm with an extremely low error rate that can track cells in files of any size (think Terabytes!). We used it in many organisms, including zebrafish, to study how organs form and linked it to gene expression www.biorxiv.org/content/10.6... +🧪

Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...

A microbiome gut-brain pathway influenced by intestinal metabolites, innate immune responses, vagal nerve signaling and hippocampal memory encoding, impacts the rate of cognitive decline. Many potential points of intervention are described.
#Science 🧪

Aging may feel gradual… but what if it’s not?
In our recent paper, we tracked fish continuously from puberty until death.
This gave us a unique view of how aging unfolds across the adult lifespan.
🧵

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Folks, it is finally out! Our paper on T2T assemblies of the zebrafish genome is on BioRxiv:
www.biorxiv.org/content/10.1...

Our Stem Cell Reports cover story titled, “GABA produced by multiple bone marrow cell types regulates hematopoietic stem and progenitor cells” is out today! doi.org/10.1016/j.st...

The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.

The shutdown of USAID has already killed hundreds of thousands of people.

It was also the most effective soft power organization on planet earth helping American interests across the globe.

This was a powerfully foolish thing to do, inhuman and cruel.

www.newyorker.com/culture/the-...

Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

Kmo restricts Salmonella in a whole organism infection model by promoting macrophage lysosomal acidification through kainate receptor antagonism Author summary Standard therapy for bacterial infections involves antibiotics to clear pathogens. However, the host immune system can also efficiently eliminate bacteria. We have recently shown that a...

Very happy to share the continuation of our discoveries on how the kynurenine pathway regulates innate immune responses during Salmonella infection. Congratulations to Emily Goering for leading this work and for starting her postdoctoral journey! 🥂👏🏻🍾

journals.plos.org/plospathogen...

arXiv will no longer accept review articles and position papers unless they have been accepted at a journal or a conference and complete successful peer review.

This is due to being overwhelmed by a hundreds of AI generated papers a month.

Yet another open submission process killed by LLMs.

Gut–brain communication: types of sensory nerves and mechanisms of activation Nature Reviews Gastroenterology & Hepatology, Published online: 28 October 2025; doi:10.1038/s41575-025-01132-1This Review explores the different types of sensory nerves involved in gut–brain communication, detailing the locations of these nerve endings in the gut and their mechanisms of activation. Insights and new information regarding spinal and vagal afferents alongside viscerofugal neurons are detailed.

New online! Gut–brain communication: types of sensory nerves and mechanisms of activation

Free Vaccine Clinics in Boston Everyone ages six months and older is encouraged to get the updated flu and COVID-19 vaccines. Pregnant parents, babies, and older adults should consult their health care professional about RSV vaccin...

We’re offering free vaccine clinics in Boston. Vaccines are safe, effective, and protect against serious illness. Getting vaccinated keeps you healthy and helps protect your family, friends, and community.

Find upcoming vaccine clinics at boston.gov/vaccine-clinics.

“Blame your parents if you can’t pay enough attention." At least when you are a zebrafish! Our new study on attentional switching together with Kumaresh Krishnan, @paulapflitsch.bsky.social , @zwitscherarmin.bsky.social and Florian Engert is out in Science Advances:
doi.org/10.1126/scia...

Metainflammation alters neutrophil function and migration in vivo in response to tissue injury Authors provide a platform to study systemic immune response to threats in vivo under metainflammation context using a diet-induced metainflammation zebraf

🧪📣The final version of our latest paper is out!!🤗

"Metainflammation alters neutrophil function and migration in vivo in response to tissue injury"

Go check it out in case you haven't yet😉🔬🐟
#zebrafish
#neutrophils
#injury
#microscopy
#metainflammation
#MetabolicSyndrome

Not your everyday view!

#Zebrafish #Research ❤️

More beautiful biology! Z-stack maximum projection confocal image of a section of the cow #cerebellum. Magenta: neurofilament heavy chain, green: actin, blue: DAPI

#Axons #microscopy #biology #science

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

Awesome work from the Lempradl lab showcasing the precise regulation of metabolism during embryogenesis in our fruit fly friends!

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...

www.nature.com/articles/s41...