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Posts by Sofía Vieto

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Architecture of the neutrophil compartment - Nature Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and ...

I’m thrilled to introduce you to the NeuMap! our latest work in@nature.com. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour de force www.nature.com/articles/s41...

4 months ago 12 4 1 2
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Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

9 months ago 62 25 3 1
Fig. 2 Whole-body estimates of sea otter metabolism scaled to body mass.

Estimated scaled whole-body metabolic rates include predicted [BMR; predicted on the basis of scaled rate for eutherian mammals], sea otter resting metabolic rate, and whole-body skeletal muscle leak capacity.

Fig. 2 Whole-body estimates of sea otter metabolism scaled to body mass. Estimated scaled whole-body metabolic rates include predicted [BMR; predicted on the basis of scaled rate for eutherian mammals], sea otter resting metabolic rate, and whole-body skeletal muscle leak capacity.

Several mammal species live in cold-water environments thanks to adaptations like blubber and large size. A notable exception is the sea otter—so how does it stay warm?

A 2021 Science study found an answer: skeletal muscle thermogenesis.

Learn more on #WorldOtterDay: scim.ag/4jjvMDL

10 months ago 115 23 2 1
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"Psychological safety" was the #1 predictor of an effective team in a study by Google. 'In other words, for a diverse team to work to its fullest capacity, everyone on the team must feel that it is safe to voice his or her opinions without being ridiculed.' 🙏@virusesimmunity.bsky.social

11 months ago 31 6 1 1
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Opinion | How to Live Healthier for Longer (Gift Article) A new era of medical care is upon us.

Here's what is exciting about the science of aging
my op-ed @nytopinion.nytimes.com
as presented in depth in SUPER AGERS (out 6 May)
www.nytimes.com/2025/04/21/o...

1 year ago 162 41 9 7

Thanks for joining us @itaiyanai.bsky.social We had a great time hosting you! You really know how to engage an audience 🥳

1 year ago 3 0 1 0

Don’t miss @alazozcan.bsky.social talking about neutrophils of the skin. She’s amazing!!

1 year ago 2 0 1 0
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Opinion | The Uncertain Fate of the Young American Scientist (Gift Article) Young researchers are choosing between staying in science and staying in the United States.

www.nytimes.com/2025/04/03/o...

Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security

1 year ago 475 301 18 56
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Matrix-producing neutrophils populate and shield the skin Nature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...

Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork!
Free link: rdcu.be/eeeA2
www.nature.com/articles/s41...

1 year ago 66 27 8 5
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Presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical response to PD-1 blockade in renal cell carcinoma Abstract. Immune checkpoint inhibitors (ICI) targeting the PD-1 pathway have transformed treatment of advanced renal cell carcinoma (RCC), but mechanisms underlying therapeutic response remain largely...

1/Excited to share our latest work in Cancer Discovery @theaacr.bsky.social. Led with #MiyaHugaboom and @kstreet.bsky.social, we show that the presence of tertiary lymphoid structures and exhausted tissue-resident T cells determines clinical responses to PD-1 blockade in #RCC: brnw.ch/21wQUU4

1 year ago 5 2 1 1