Thanks Misha for the shout-out!
It has been a truly mind-opening journey. WHOLISTIC is one step towards whole-organism neuroscience and a true physiological observatory - with extensions on the way! I am continually amazed by what the data reveals - so much remains to be discovered and mined.
You're not (at least that we've found).
Agree it's a powerhouse team and backing, but HRS9531 (Kailera's lead program) isn't even close to best-in-class. Based on the human clinical data so far it'll be 4th place when approved, and competing with a better generic by 2032.
Some really cool work we've been doing @oliolabs.bsky.social. New science opens the door to better medicines.
In this week's edition of our healthcare newsletter InnovationRx, @amyfeldman7.bsky.social & I look at:
💉 The Trump Administration's mixed messaging on vaccines.
🩺 Sex differences in side effects of GLP-1 medications
🤖 Using AI to predict epidemics
And more!
www.forbes.com/sites/innova...
Some really cool work we've been doing @oliolabs.bsky.social. New science opens the door to better medicines.
Check out what we're working on at Olio Labs!
70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men.
What is driving this difference?
We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out:
This guy.
Congrats to Xuefeng and the authors on a great paper.
academic.oup.com/sleep/advanc...
Sometimes things do line up between species
If anyone is interested in going this direction in their research feel free to reach out, I'm happy to discuss or brainstorm what kind of experiments could come next!
In those animals we didn't observe a correlation between ripples and glucose fluctuations. To me, this strongly suggested pancreatic insulin release is a mechanistic intermediate
Wow, thanks so much Adrien! It was such an exciting project to work on, and many directions to follow up. Another *really hidden gem (it didn't end up in the paper), we (@jocarpenter and I) treated three rats with streptozotocin which effectively kills beta cells in the pancreas...
Could I get added?
Any chance I could get added? This was super helpful for finding everyone, thanks!
I'd read that paper