These images show live embryos of animals (jellyfish, crustacean, worm, sea urchin, sea squirt, beetle) and one of animals closest single-celled relatives. They were captured taking advantage of fluorescent proteins localised on the outer membrane of cells, allowing us to observe cell outlines. 1/9
In animals with large genomes, finding cis-regulatory elements can be very challenging. Enhancers can be located tens/hundreds of kb away from their target promoters. We face this challenge in Parhyale, with >3 Gbp genome.
We just published a preprint describing how we are tackling this problem. /1
Annonce officielle de l’IGFL pour le recrutement du poste cité ci-dessus
L’IGFL recrute un•e Professeur•e des Universités en biologie moléculaire (CNU 64), UCBL Lyon 1.
Enseignement L2-M2 (Biochimie et Biologie Moléculaire) + projet en biologie moléculaire des eucaryotes au sein de l’IGFL.
Détails: shorturl.at/K5Dno
#Recrutement #BiologieMoleculaire
Un poste de Professeur des Universités va être ouvert lors de la campagne d’emploi 2026 à l’université Claude Bernard Lyon1 -
Profil Recherche : Biologie Moléculaire des Eucaryotes.
Profil Enseignement: Biologie Moléculaire.
Profil ci-joint.
Merci de diffuser dans vos réseaux.
Such a pleasant moment listening to the original science from @audeber.bsky.social today at @igflyon.bsky.social @ensdelyon.bsky.social. Out of the box ideas, Outstanding tools, Out of my comfort zone… Totally great!
Supp. Fig. 1 - LpWJL mediates midgut growth through cell area increase. Representative images of anterior and posterior midguts from size-matched LpWJL-associated (D7) and GF (D11) yw larvae. Midguts were dissected and stained for Discs large (Dlg, red), a septate junction marker, and DAPI (blue) to mark nuclei. Scale bar represents 100μm.
Bacteria-dependent ecdysone lengthens hungry stomachs
This Research Highlight showcases work from Longwei Bai (@longweibai.bsky.social), François Leulier (@francoisleulier.bsky.social) and colleagues at @igflyon.bsky.social
journals.biologists.com/dev/article/...
White IGFL seminar flyer. Top left: IGFL logo in pink. Center top: title “External seminars – IGFL” above a stylized blue question mark. Speaker name: Anamaria Necsulea. Laboratory of the speaker: Laboratoire de biométrie et biologie évolutive (LBBE, Lyon). Invited by: Eglantine Heude. Date: 29/01/2026. Title: “Convergent evolution of genomes and phenotypes in birds.” Abstract summarizes comparative and functional evolutionary genomics in birds, focusing on convergent phenotypic evolution. Main case study: repeated reduction or loss of the intermittent male phallus in multiple avian lineages. The work analyzes hundreds of bird genomes to identify parallel changes in protein-coding genes, non-coding regulatory elements, and gene expression associated with this developmental and evolutionary transition. Bottom section: short CV detailing PhD (University of Lyon), postdoc in Lausanne, junior group leader at EPFL, and current CNRS researcher at LBBE studying evolution of gene regulation and phenotypes. Right side: portrait photo of the speaker outdoors, smiling, short hair, wearing a dark top.
IGFL external seminar
Birds keep losing their penises, repeatedly. Not by chance. Anamaria Necsulea (LBBE Lyon) shows how changes in gene regulation and non-coding DNA drive convergent developmental loss of the male phallus across avian evolution.
Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Review process via @reviewcommons.org and @dev-journal.bsky.social
1/3
#ResultatScientifique🔎| Et si le microbiote intestinal pouvait agir comme un régulateur hormonal pour lutter contre la malnutrition ?
✍️ @francoisleulier.bsky.social
🤝 @cnrs-rhoneauvergne.bsky.social @igflyon.bsky.social @ensdelyon.bsky.social
📕 @dev-journal.bsky.social
▶️ buff.ly/R1VJvDm
Plus que quelques jours pour candidater. Rejoignez-nous!
Amazing to have @alainchedotal.bsky.social with us today @igflyon.bsky.social in front of a full room of people from all over the @ensdelyon.bsky.social campus! Very happy start of 2026 🤯
Very very excited to have Elly Tanaka from @imbavienna.bsky.social for our external seminar series @igflyon.bsky.social! Thanks Eglantine Heude for hosting 🤯
Mobilité interne CNRS : l’IGFL recrute un·e assistant·e ingé pour renforcer ses travaux sur modèles aquatiques et biologie cellulaire. Environnement technologique solide, missions variées recherche/élevages. Candidatures jusqu’au 15/01/2026.
emploi.cnrs.fr/Offres/MOBIN...
Very proud to have defended my HDR (« Habilitation à diriger les recherches ») at @ensdelyon.bsky.social. Many thanks to the jury for their constructive feedbacks @clairewyart.bsky.social @francoisleulier.bsky.social @FlorenceRuggiero @PaulineSpéder @stemdevevo.bsky.social @OlivierRaineteau!
It's done! I am now a PhD for real!
I defended my PhD thesis last week and what an incredible day it was. I am very grateful to all the members of @igflyon.bsky.social who made these last 4 years and 8 months so memorable. I will cherish all these memories 😊
What are these?
You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social
see doi.org/10.1101/2024... 🧵
When the clock’s feedback loop breaks, chromatin keeps ticking 🕒
Work from @clocklab-igfl.bsky.social reveals how H3.3-linked PBAF/cBAF shifts sustain BMAL1 activity and reshape circadian chromatine, linking epigenetics to metabolic and ageing control.
🔗 nature.com/articles/s41467-025-64045-2
Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one?
Check our latest preprint, led by @mmasoura.bsky.social, to find out!
www.biorxiv.org/content/10.1...
Developping Fucus embryo labelled with the orange fluorescent probe SBIS (autofluorescent chloroplasts in red).
📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p
with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH
Our new study, just accepted in the Journal of the Endocrine Society
👉 doi.org/10.1210/jend...
We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.
Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale
apply here: www.averof-lab.org/pages/tracman
1/3
Comme tous les ans, l’IGFL accueillera la fête de la science la semaine prochaine. Le public général est bienvenu le samedi 4 octobre. Nous espérons vous voir nombreux!
www.ens-lyon.fr/indexation/a...
Ces travaux impliquent l'Institut de génomique fonctionnelle de Lyon. @igflyon.bsky.social 👏
So happy to have Dafni @drosostalis.bsky.social at @igflyon.bsky.social today, for an exciting fly physiology talk! “Mind the gut”!
Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6
Ces travaux impliquent notamment des scientifiques de l' @igflyon.bsky.social 👏
cc @ensdelyon.bsky.social
Now available in its final form @narjournal.bsky.social !
doi.org/10.1093/nar/...
Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.
Flyer announcing a seminar by Jean Livet from the Institut de la Vision, hosted by Jonathan Enriquez at IGFL Lyon on June 30th, 2025. The talk is titled “Topography and topology in a central sensory neuronal projection.” The abstract explains that in the vertebrate brain, sensory pathways connect neuronal relays with high precision over long distances. To study these circuits, dense single-neuron tracing and large-volume microscopy are used. Jean Livet will discuss their efforts in connectomic mapping using multicolor labeling, focusing on an auditory relay to reveal its topographical and topological organization. The flyer also includes a short bio: Jean Livet completed his PhD on motor neuron development at IBDM Marseille, developed the Brainbow labeling method during his postdoc with Jeff W. Lichtman in the USA, and has led the “neurogenesis and circuit development” team at the Institut de la Vision since 2008.
Excited to host Jean Livet (Institut de la Vision) at IGFL Lyon on June 30th! He’ll share how multicolor labeling and large-volume microscopy reveal the topography and topology of central sensory circuits. A must for connectomics fans! 🧠🔬✨
Cartoon of Steven Van Belleghem riding a giant beetle over green islands, holding a camera and flying scientific papers. A hawk and butterfly accompany him, symbolizing his evolutionary genomics research on butterflies, Daphnia, and beetles.
🦋 Butterflies and beyond! Steven Van Belleghem is now at IGFL revealing how genomes evolve into pangenomes, shaping adaptation and gene regulation in butterflies and Daphnia. Don’t miss this dive into the mysteries of evolution! #EvolutionaryGenomics
🧬 From genomes to pangenomes to adaptation!
Join us June 2 at 11am in Salle des Thèses (IGFL) for Steven Van Belleghem’s talk on how structural genome variation and regulatory elements drive evolution—featuring butterflies, beetles, and Daphnia. 🦋🪲🦐
