4. The GLP-1RA induced a significant increase in diverse mitochondrial proteins relative to caloric restriction.

There is a lot more coming on this topic, but the initial read is that GLP-1RA drugs are good for the liver and muscle.🧪

3. The extra lean mass loss seen in human trials comes from the loss of fat from the liver. Since on DXA the liver is considered lean mass and the liver mass decreased up to 50% with dual agonists, this could explain the 40% lean mass loss number from human trials.🧪

🧪A couple of key findings:

1. GLP-1 agonists (and dual agonists) don't cause significantly more muscle loss than calorie restriction alone.

2. Strength relative to body weight goes up both in mice and humans.

Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans Langer et al. show that GLP-1 medicines mildly reduce absolute muscle mass but improve relative mass and running performance in mice. Despite similar changes to body weight, GLP-1RA affects the muscle...

🧪New collaborative paper with the new lab of @henninglanger.bsky.social

Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans: Cell Reports Medicine www.cell.com/cell-reports...

So, even though we want these patients to exercise, we need to realize they are much more likely to have serious tendon injuries when they do activity.

This suggests that people with kidney disease have weak tendons, even before they get corticosteroids and other drugs known to weaken them further. In fact, a third of all spontaneous tendon ruptures happen in people with kidney disease.

Kidney disease impairs tendon function in rats Abstract figure legend This study demonstrates for the first time that tendon strength is reduced in a rodent model of chronic kidney disease (8 weeks of 0.25% adenine feeding) and confirms concurren...

🧪 In our latest paper, my great student Christopher Hayden fed rats a small amount of adenine, which crystalizes and causes kidney disease.

The paper's new finding was that tendon quality decreased significantly in both males and females.

physoc.onlinelibrary.wiley.com/doi/10.1113/...

Caffeine decreases muscle and tendon protein synthesis and engineered ligament strength in vitro and attenuates adaptation to exercise in mice | Journal of Applied Physiology | American Physiological ... Caffeine is a well-known stimulant that is widely used to increase alertness and performance. However, there is little information on the effect of chronic caffeine consumption on exercise adaptations...

If you send her this link she can access the paper.

journals.physiology.org/doi/full/10....

APSselect | APS

Honored that our recent paper on how caffeine altered adaptation to exercise was picked for APSselect. 🧪

journals.physiology.org/apsselect

🧪Even given these shortcomings, if you are looking to maximize exercise training, limiting caffeine intake may be warranted. Also, using a high caffeine pre-workout supplement may not be the best idea (since more blood, and therefore caffeine, will flow to the muscles you are training).

🧪Before you yell at me, or god forbid stop drinking coffee, realize two things. First, the dose of caffeine is quite high; equivalent to 6+ cups of coffee a day. Second, the effect in vivo (in mice) was quite small.

Caffeine Decreases Mu scle and Tendon Protein Synthesis and Engineered Ligament Strength In Vitro and Attenuates Adaptation to Exercise in Mice | Journal of Applied Physiology | American Physiological... Caffeine is a well-known stimulant that is widely used to increase alertness and performance. However, there is little information on the effect of chronic caffeine consumption on exercise adaptations...

🧪Our latest paper is out! But, it may upset a lot of people.
Caffeine Decreases Muscle and Tendon Protein Synthesis and Engineered Ligament Strength In Vitro and Attenuates Adaptation to Exercise in Mice | Journal of Applied Physiology journals.physiology.org/doi/abs/10.1...

The VISA-C Questionnaire: A Self-Administered Assessment to Measure Finger/Hand/Wrist Pain in Climbers - Sports Medicine - Open Background Rock climbing places high loads through the hands, wrists, and fingers, leading to high injury rates, with the highest proportion in the fingers. Until now, there has been no attempt to categorize pain in the forearm to assess readiness to train. The purpose of this study was to create a questionnaire, the VISA-C (Victorian Institute of Sports-like Assessment; C for climbing), to measure forearm pain and determine how pain limits training. Methods We asked rock climbers aged 18 to 50 years old, who met the participation criteria and gave consent, to complete a survey containing 8 questions. We analyzed data from climbers who responded to the online questionnaire in the 9-week period between November 5, 2024, and January 8, 2025. We obtained a diverse international sample with English-speaking respondents from 54 countries. We included a supplementary questionnaire to compare the survey results against participant demographics, lifestyle, health, and sport-specific history and habits. Results We analyzed data from 1,110 climbers who completed the form. VISA-C scores were significantly different as a function of pain. The mean VISA-C score of the group with no pain was the highest (83.21/100), lower in the group reporting some pain (72.28/100), and lowest in the most severe group with activity-limiting pain (60.05/100), indicating our questionnaire scales with pain severity. We then used the secondary data gathered on our participants to search for associations between pain or skill level and demographic, health, and training habits. Of these, only blood pressure was associated with differences in VISA-C scores. Conclusions VISA-C score scaled with pain and can be compared broadly across all major demographics. We observed interesting trends in our secondary analyses. Several variables correlated significantly with either VISA-C score or climbing skill level, but none correlated well with both. Many of the variables we compared agreed with existing literature or pointed to novel associations that warrant more investigation.

Our latest paper is a quite applied one. It is a readiness questionnaire for rock climbers. We think that this will provide a quantitative measure of the effect of different training methods on finger tendon health and performance.

sportsmedicine-open.springeropen.com/articles/10....

🧪

This should be a great session. Hopefully, we'll get to answer some questions on pros and cons of different models for studying this difficult tissue.

Interested in injury prevention and rehabilitation in baseball? This might be an interesting meeting.

I will talk about ways to possibly prevent injury and how to optimize native tissue repair after injury.

It should be fun!

tinyurl.com/py869z8k

Exosome enriched serum enhances engineered ligament mechanics and collagen content with no additional benefit of resistance exercise Following resistance exercise, systemic changes foster improved functionality of tendons and ligaments. Post-exercise, muscle tissue releases exosomes…

🧪 New paper alert! We keep trying to understand muscle-tendon crosstalk. Here we determined whether exosomes could explain why serum after resistance exercise makes bigger stronger tendons. Contrary to our hypothesis, it is not exosomes. The search goes on.

www.sciencedirect.com/science/arti...

Email me at kbaar@ucdavis.edu and I will send it to you

Heartbreaking

That was a textbook Achilles tendon rupture.

And there was no one prouder than @drcontrexin.bsky.social

You were amazing!

Today I had the honor of speaking in front of nearly 3000 people today at the Woodland #NoKings rally. WE FEAR NO KING BECAUSE WE DONT HAVE ONE ✊🏾✊🏾✊🏾✊🏾 let’s gooooooo

Join our information session for prospective online Anatomical Sciences students!

#anatomy #anatomicalsciences #learnonline #onlinelearning #humananatomy

Headshot of Mark Huising against a dark blue background with white text that reads, "From labs to Lives: How Research Funding Solves Real World Problems" and his quote, "[Reduced federal funding] is already stymieing the vital trainee pipeline that U.S. biotech and pharmaceutical companies rely on to maintain the edge in their internationally competitive fields."

Diabetes affects millions of people, but what if we could better understand how the body naturally regulates blood sugar? Mark Huising is leading NIH-funded research to study how beta cells in the pancreas work together with neighboring cells that secrete hormones that control insulin secretion.

Happy Birthday Abigail!

Here is a chance for a young scientist to join one of the most respected labs in the country.

You can do it once a day. For elite athletes trying to come back as fast as possible we might load more. But, for us mere mortals daily is great

Yes. Good luck

A flyer for stand up for science Sacramento on March 7 from 12-4.

Please join us in Sacramento on Friday, March 7 from 12-4 PM to Stand Up For Science!

Outside my expertise. Sorry