🧠 Thank you for joining us at the recent #EANOYoungsters Journal Club session: INDIGO 2.0 – the next episode!
👉 Missed it or want to revisit the discussion? Watch the full recording now on YouTube: youtu.be/VboCYAtgXrY?...
We look forward to seeing you at the next session!
#NeuroOncology #EANO
Somatic mutations in autoimmune lymphocytes may allow them to escape tolerance constraints through a polyclonal cascade of somatic evolution @nature.com @sangerinstitute.bsky.social @ims-mrl.bsky.social @cuh.nhs.uk @imartincorena.bsky.social
www.nature.com/articles/s41...
Scalable genotyping in fixed transcriptomes resolves clonal heterogeneity via single-cell sequencing #SingleCell 🧪🧬🖥️
www.biorxiv.org/content/10.64898/2026.04...
Capturing somatic mutations in single-cell probe-based assays (ie. 10X Flex) is a hard task, especially if you don't know *exactly* the mutations you want to capture, or if your target sequence is a mutational hotspot with many possible alternative alleles. Here's the way we pulled this off. Enjoy!
@biorxivpreprint.bsky.social Identity, ontogeny, and age-related changes in splenic white pulp macrophages in mouse and human spleen
www.biorxiv.org/content/10.6... @feinberg.northwestern.edu
New REVIEW published @natcancer.nature.com !
'Single-cell and spatial profiling in cancer biology and clinical oncology'
✏️By Benjamin Izar, Elham Azizi and co-authors
🔗 www.nature.com/articles/s43...
Fibroblasts underpin immune-competent niches in the healthy and diseased CNS. Schematic representation of the topological organization of fibroblasts along the vascular tree and across meningeal and brain parenchymal compartments in the context of (A, B) homeostasis, (C, D) infection, (E) autoimmunity, and (F) sterile tissue injury. The provision of cytokines, chemokines, survival factors, and ECM components by local fibroblasts are indicated in each condition. The legend of depicted cell types and vasculature is provided. (A) In the homeostatic CNS, fibroblastic cells include mural cells, perivascular fibroblasts situated abluminal to mural cells, and meningeal fibroblasts. (B) In the steady-state condition, PDPN+ FRC-like cells are limited to DALTs positioned at the intersect of rostral-rhinal, olfactory, and superior sagittal sinuses. In (C) chronic dural infection and (E) autoimmunity, persistent inflammation is associated with TLS formation. TLS are underpinned by FRC-like cells and FDCs providing T and B cell chemoattractants, survival factors, and canonical markers of FRCs. (D) In infections of the brain parenchyma, similar chemokines and FRC markers are upregulated in the absence of TLS formation. (E) In the context of deep gray matter injury, perivascular fibroblasts of the Virchow-Robin space constitute a major source of scar-forming cells. In addition to profuse ECM deposition, scar-forming fibroblasts secrete myeloid cell survival factors and chemokines to drive early and late phase scarring, respectively.
🤩 new review on CNS perivascular fibroblasts interactions in injury, disease & neuroimmunity - from Natalia Barbara Pikor group @ethz.ch led by Margaux Océane Verdon - check it out!
academic.oup.com/jimmunol/art...
Tissue organization is fundamental to how tissues function - yet in cancer such spatial patterns can progressively break down. Ever wondered how?!
Check out our new study, where we investigate how lymphoma reshapes lymph node architecture 👀
congrats Anna, so cool!!
Another just published manuscript from our lab, congratulations to chintan et al!!
new manuscript out from our lab in nature immunology today - congratulations to max and lukas!!
New insights into the #spatial patterns of IDH mutant gliomas by Rouven Hoefflin from the Tirosh Lab
www.biorxiv.org/content/10.6...
Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age @nataging.nature.com @stephenquake.bsky.social @stanforduniversity.bsky.social
www.nature.com/articles/s43...
Review @jem.org
Myeloid diversity in tumors: Shaped by genes, location, and time
rupress.org/jem/article/...
Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties. @cp-neuron.bsky.social www.cell.com/neuron/fullt...
Resident tissue macrophages maintain intraocular pressure homeostasis. @cp-immunity.bsky.social www.cell.com/immunity/ful...
Glofitamab CNS penetration @bloodadvances.bsky.social
- 8 PCNSL/SCNSL, 7 LBCL, 1 BL
- 3/8 CRS (all G1-2), no ICANS
- 7/8 response (4 CR, 3 PR)
- 2 PCNSL durable CRs
- CSF: +glofi with activity in vitro
Bridging to CAR for SCNSL or even monotx for PCNSL. #lymsm
ashpublications.org/bloodadvance...
Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease: Cell Reports Medicine
www.cell.com/cell-reports...
Join us in Münster to study the immunology of cerebrospinal fluid and the meninges in a human-centric fashion – apply for PhD student position here:
jobs-sf.ukmuenster.de/job/UKM-PhD-...
@biorxivpreprint.bsky.social A framework for reparative CAR T engineering in the CNS @idoamitlab.bsky.social @weizmanninstitute.bsky.social @jonykipnis.bsky.social @washumedicine.bsky.social
www.biorxiv.org/content/10.6...
Preprint: TREM2⁺ myeloid cells limit perioperative CAR T-cell efficacy, highlighting need for neoadjuvant strategies to overcome post-resection immunosuppression in GBM @biology-unige.bsky.social
www.researchsquare.com/article/rs-8...
Thrilled to share our latest work highlighting Bergmann glial development in the human cerebellum. @neurodevkathy.bsky.social @pnas.org
www.pnas.org/doi/10.1073/...
Crosstalk between Stromal cells and Macrophages Shapes Host Immunity to Mycobacteria www.biorxiv.org/content/10.64898/2026.02...
A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams.
www.biorxiv.org/content/10.1...
On the balance of knowledge @rmedzhitov.bsky.social @natrevimmunol.nature.com
www.nature.com/articles/s41...
Meningeal blood vessel blockage enhances anti-glioblastoma immunity www.cell.com/cell/fulltex...
Childhood brain tumors instruct cranial hematopoiesis and immunotolerance @natgenet.nature.com
@gilbertsonlab.bsky.social @cruk-ci.bsky.social
www.nature.com/articles/s41...
