Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential - Molecular Neurodegeneration Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellular compartments. They carry a range of cargo biomolecules, including protein a...

#ExtracellularVesicles in #TDP43 proteinopathies: pathogenesis and #biomarker potential

Elizabeth R. Dellar @lizziedellar.bsky.social Lara Nikel, Stephanie Fowler...Alexander G. Thompson #exosome #ALS #FTD

molecularneurodegeneration.biomedcentral.com/articles/10....

Solid phase transitions as a solution to the genome folding paradox - Nature In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rathe...

Forget liquid-liquid phase separation, here comes solid phase transition 😱

www.nature.com/articles/s41...

Cringe!

Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...

1/ 🚨We’re thrilled to share our latest study:

"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟

www.biorxiv.org/content/10.1...

How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️

We enjoyed a wonderful Christmas lunch together and wish you a Merry Christmas and a Happy New Year 2025, filled with exciting discoveries!

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration Aberrant aggregation of the prion-like, RNA-binding protein TDP-43 underlies several debilitating neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). Here, we define how ...

New preprint from the Shorter lab: www.biorxiv.org/content/10.1...

Amino Acid Transfer Free Energies Reveal Thermodynamic Driving Forces in Biomolecular Condensate Formation The self-assembly of intrinsically disordered proteins into biomolecular condensates shows a dependence on the primary sequence of the protein, leading to sequence-dependent phase separation. Methods ...

www.biorxiv.org/content/10.1...