Game of microbes: a wildling’s guide Laboratory mice housed under specific pathogen-free conditions are the standard model in biomedical research. However, frequent germ-free rederivation and barrier housing restrict microbial exposure a...

Please share! Ever wondered how to establish and maintain wildlings – and why they matter? Our new paper “Game of microbes: a wildling ’s guide” is now out in Trends in Microbiology dlvr.it/TRl1Zs - Thread below with key previous work
@cp-trendsmicrobiol.bsky.social @cellpress.bsky.social @FAU.de

Game of microbes: a wildling’s guide Laboratory mice housed under specific pathogen-free conditions are the standard model in biomedical research. However, frequent germ-free rederivation and barrier housing restrict microbial exposure and interactions with commensal and pathogenic microorganisms. In contrast, wild mice encounter diverse microbial environments, undergo natural selection, and rely on robust immune responses for survival. Consequently, lifelong microbial exposure is a key driver in shaping mammalian physiology, establishing the need for naturalizing rodent models in biomedical research. By defining the concepts of ‘microbial self’ and ‘microbial nonself’, we propose a four-step guide for establishing a multigenerational wildling colony that accounts for both microbial self and microbial nonself. This reestablishes the common biological link shared by all free-living mammals, thereby improving the comparability between murine and human studies.

Game of microbes: a wildling’s guide

Please share! We hire PIs working in microbiome, metabolism, cancer, allergies, autoimmunity, neurological and infectious diseases. We offer SPF-, gnotobiotic- and wildling-models + generous lab space + top notch equip., e.g. SONY ID7000, 10X Xenium, MACSima. Contact: stephan.rosshart@uk-erlangen.de

Following up on the findings from our first article (wellcomeopenresearch.org/articles/10-...), here is the preprint of our study on neuroimmune alterations in school-aged children with perinatal HIV exposure

#publicationalert
#preprintalert
#HIV
#paediatrics

Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions Stroke is a devastating neurological event with a high risk of mortality that results in long-term sequalae that extend beyond the central nervous sys…

New paper out from the lab, led by Maddy Hurry. We investigate how stroke leads to peripheral complications in the gut through dysregulation of IgA mediated host-commensal crosstalk.
@lydiabeckeriii.bsky.social
@diiirm.bsky.social

www.sciencedirect.com/science/arti...

We had such a great time in #Montpellier at the #IES2025. Big congratulations to our awards receivers: Glenn for the best oral abstract talk and travel grant, @danielcrepaz.bsky.social for best abstract slam and @kingji.bsky.social for travel grant! #eosinophils

Really thrilled to have been awarded an @acmedsci.bsky.social Springboard Award! This new PI thing is definitely starting to feel real now!

The #Springboard25 will help me to kickstart some cool work on innate-like T cells in skin and lungs at the @lydiabeckeriii.bsky.social! Exciting times ahead!

Extremely thankful to get the opportunity to present my work at the WIRM! #WIRM2025