Renovating the Barnes maze for mouse models of dementia with STARR FIELD: A 4-day protocol for learning rate, retention, and cognitive flexibility - PubMed Land-based spatial mazes are a low-stress method to evaluate learning in rodent models of dementia. By using innate exploratory and hiding behavior, the Barnes maze requires fewer trials, allowing exa...

pubmed.ncbi.nlm.nih.gov/41966430/

congrats to the Aldridge lab on getting this important methods paper out!

I've been quiet on social media recently - but I miss the opportunity to talk about all the cool things happening with other scientists since the days of Twitter. So - congrats to Hannah Stutt on defending her PhD on dorsal striatal dopamine and timing. Next step: on to awesome postdoctoral work!

Linear predictive coding electroencephalography algorithms predict mortality in Parkinson’s disease Mortality is increased in Parkinson’s disease (PD) and is difficult to predict because of its heterogeneity and the availability of few reliable progn…

Our latest paper showing that a few minutes of EEG can predict mortality in PD is now up: www.sciencedirect.com/science/arti...

Our lab's posters at SFN:

Congrats to Alexandra Bova on winning a BBRF Young Investigator Award!

The Journal of Neuroscience: 45 (37)

Our issue on Computational Properties of the Prefrontal Cortex is now:
www.jneurosci.org/content/45/3...

These articles capture some of the incandescence of the CPPC conferences...
narayanan.lab.uiowa.edu/home/cppc2024
cppc.web.ox.ac.uk
accl.psy.vanderbilt.edu/blog/2018/10...

D1FLP mice are now available from JAX!
www.jax.org/strain/039507

Detailed in this paper: pubmed.ncbi.nlm.nih.gov/39701542/

Let us know if they work for you...

Linear predictive coding electroencephalography algorithms predict Parkinson's disease mortality using out-of-sample tests Background: Parkinson's disease (PD) increases mortality is difficult to predict because of its heterogeneity and the availability of very few reliable which prognostic markers. Objectives: We used el...

Our latest paper predicting PD mortality from ~2 minutes of resting-state EEG : www.medrxiv.org/content/10.1...

Timing, movement, and reward contributions to prefrontal and striatal ramping activity Across species, prefrontal and striatal neurons exhibit time-dependent ramping activity, defined as a consistent monotonic change in firing rate across temporal intervals. However, it is unclear if ra...

Our latest work: www.biorxiv.org/content/10.1...

We show that corticostriatal ramping activity can't readily be explained by movements using motion tracking, and that ramping can't readily be explained by reward anticipation in mice performing timing and Pavlovian tasks.

Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...

We find that 4 Hz STN stimulation in *humans* changes decision thresholds:

Data: narayanan.lab.uiowa.edu and osf.io/hsz3u
With Rachel Cole and Jim Cavanagh

Our work from a great collaboration now out at Brain Stimulation: doi.org/10.1016/j.br...

We find that 4 Hz STN stimulation in *humans* changes decision thresholds:

Data: narayanan.lab.uiowa.edu and osf.io/hsz3u

Amphetamine scrambles the brain's sense of time by degrading prefrontal neuron coordination Researchers have found that amphetamine alters how the brain processes time, increasing variability in the activity of neurons that encode temporal information. The study provides insight into how the...

write-up of our amphetamine paper: www.psypost.org/amphetamine-...

another new preprint from our group on predicting cognitive changes in PD from resting state fMRI: medrxiv.org/content/10.1...

Diverse activity in prefrontal projections promotes temporal control of action Prefrontal neurons can have diverse activity during cognitive functions like working memory, attention, and timing; however, the importance of this heterogeneity is unclear. Our goal was to better und...

Our latest preprint on projection-specific tracing of prefrontal activity: www.biorxiv.org/cgi/content/...

Lots more details in the paper. This paper challenged our fundamental view of what we think amphetamine does…

Amphetamine has been thought to reliably affect timing accuracy. We find in a meta-analysis and in our data that it actually more reliably affects precision:

Our work showing that amphetamine affects behavior by degrading prefrontal temporal variability is now out at Neuropharmacology: doi.org/10.1016/j.ne...

Work by Matthew Weber and colleagues:

As always, data and code at: narayanan.lab.uiowa.edu/datasets

That's us!

New preprint from our group showing that drugs that enhance glycolysis slow neurodegeneration in Alzheimer's disease - data from yeast to humans:
www.biorxiv.org/content/10.1...
data: bit.ly/GlycolysisANDAD
Data and code : narayanan.lab.uiowa.edu/home/data

Congrats - awesome work - George A would have read this with interest!

What a great looking lab! Best of luck to Mackenzie Rysted at the University of Indiana...

Congrats!

May I also suggest contacting your disease-specific patient advocacy organization? For instance, I work in Parkinson's disease - and there are several societies with thousands of members here in Iowa. They need to understand the concrete impacts on patients suffering from Parkinson's disease.

How do we explain these results? We collaborated Rodica Curtu in math who implemented classic drift diffusion models. These DDMs suggest that D1 and D2 neurons provide temporal evidence. Disrupting them decreases the accumulation of temporal evidence – and predicts slowed timing.

5/5

We’ve previously reported that striatal neuron encode time by linear changes over a temporal interval – and we found that these linear changes in the striatum. However – to our complete surprise – D1 and D2 neurons had *opposite patterns* of ramping!

4/5

In line with our pharmacology data, we found that optogenetically inactivating either D2 or D1 MSNs slowed temporal control of action:
3/5

This works starts pharmacology showing that dopamine controls the timing of movement. Our work with blocking dopamine receptors systemically – and where they are most abundantly expressed – in the striatum -shows that blocking either D1 or D2 dopamine receptors slows temporal control of action:

Our latest work is up as a version of record on eLife.

elifesciences.org/articles/96287

This story a long road – but is a major advance on understanding temporal control of action.

As always, data and code are available at narayanan.lab.uiowa.edu/data
1/5

Long story short - we get great expression, and about what we might get from Cre mice. This will be a powerful tool for studying these circuits.

They will be up at Jackson (039507) soon.

Youngcho integrated FlpO - another conditional expression construct - into the D1 gene. This is distinct from the D1 Cre mice, which uses BAC transgenics: