Check out this new Review Article in TiG by the amazing Elad Dvir, a joint student of the Shifman and Meshorer labs👇👇

Beautiful work

ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection - Cell Death & Differentiation Cell Death & Differentiation - ATF3-dependent formation of inclusion bodies in polyQ-expressing human iPSC-derived neurons confers cellular protection

Are PolyQ Inclusion Bodies detrimental or protective in Huntington’s Disease? The amazing Walaa Oweis in my lab shows they are protective in human iPSC-derived neurons, confirming Finkbeiner’s observation in rodents. She further found that ATF3 is required for their formation.
🔥🔥🔥
rdcu.be/fbjil

Functional fertile sperm from mouse embryonic stem cells👇🔥

And today Shalhevet’s Flashtalk about SCA3 concluded our lab’s presentations. Kudos everyone!⚡️🧬🔬

🔥Flashtalks and posters in ILANIT FISEB meeting today by Shira Siegel, Shira Horev, Riki Masar, Eden Mishne and Avital Pushett🔥

Extracellular environment stabilization of stem cell state identity via KDM3A👇🔥

Distinct roles for SETα and SETβ in early cell fate decisions Abstract. SET, the nuclear proto-oncogene, is primarily expressed as SETα in embryonic stem cells (ESCs). Upon pluripotency exit, a transcriptional switch

Finally out! Patrick developed a system to study SET isoform specificity in ES cells, revealing a role for SETa/b switch in endoderm specification. Check it out🔥

academic.oup.com/nar/article/...

A super interesting study!👇👇👇🔥

Congratulations!

Fantastic work, congrats!

👇👇👇

Such a big loss. What an inspiration he was for so many of us

Congratulations!

The incidence of ASD in Israel is slightly higher than the rest of the world. There's no Tylenol in Israel.

👇🔥👇

Super! Congrats!🔥🥳

Thank you EMBO and EMBO members! Excited to join!

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells - Nature Communications In mammals, two major non-centromeric histone H3 (H3.1/2 and H3.3) variants, display distinct nuclear distribution patterns across the genome and use distinct deposition pathways. Here the authors rev...

🔬✨ Excited to share a major milestone from my PhD research at Institut Curie, where I am a first author in a recently published paper in Nature Communications!
www.nature.com/articles/s41...

Congrats!😀🍾

We are looking to take on an intern at EMBL Rome, for anyone interested in CRISPR and Epigenetics training.

The traineeship is 3-12-months, in Rome (Italy), should start by July, and is supervised by the outstanding @steliostsagkris.bsky.social.

#job #internship; see info below...

I am raising funds for a unique center dedicated to AIDS-impacted youth, and will run the NY marathon on their behalf. Feel free to contribute!🙂🙏🏃‍♂️‍➡️ fundraisers.nyrr.org/eran-meshorer

Thank you ISSCR for this award, on behalf of all Scientific Programs Committee members!

We showed the same phenomenon in pluripotent models of neurodegenerative diseases, as well as in AD and HD post-mortem brains:
genomebiology.biomedcentral.com/articles/10.... (unfortunately they do not cite us, despite both having worked on CHD8, among others).

👇👇👇

PRC1 and PRC2 proximal interactome in mouse embryonic stem cells Zijlmans and Stelloo et al. profiled in vivo proximal interactomes of PRC1 and PRC2 in mouse embryonic stem cells, identifying >100 proteins, including transcription factors and RNA-binding proteins. ...

PRC1 and PRC2 proximal interactome in mouse embryonic stem cells: Cell Reports www.cell.com/cell-reports...

Linker histone H1 functions as a liquid-like glue to organize chromatin in living human cells Linker histone H1, the most abundant chromatin protein, condenses chromatin, modulates DNA transactions such as transcription and DNA replication/repair, and participates in differentiation, developme...

Just out from @kazu-maeshima.bsky.social

www.biorxiv.org/content/10.1...

Congrats Anja, Leonie and Alva! Beautiful work🥂

Cool, super interesting!

It took Sci Adv 6 months (!) to review and reject our paper. A single (addressable!) review. When we appealed, it took a month to answer that we can appeal🤦. The Editor is concealed. Disgraceful and unprofessional behavior.