Placental expression of GKN1 and diminished pancreatic beta cell function during pregnancy - Diabetologia Aims/hypothesis Pregnancy is characterised by augmented pancreatic beta cell function, which is impaired in gestational diabetes mellitus (GDM). Using placental transcriptomic analysis, we aimed to id...

Powe et al identify that higher placental expression of GKN1 is associated with diminished beta cell function in pregnancy and GDM link.springer.com/article/10.1... @cepowemd.bsky.social

Our study on use and discontinuation of GLP-1 receptor agonists before and in early pregnancy was published today in JAMA. We owe it to our patients to begin the hard work of safely and rigorously delivering the advances in novel therapeutics for management of weight and glycemia to pregnancy.

Comparative effectiveness trial of metformin versus insulin for the treatment of gestational diabetes in the USA: clinical trial protocol for the multicentre DECIDE study Introduction Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. Glycaemic control decreases the risk of adverse pregnancy outcomes for the affected pregn...

Full sentence: “These findings support the continued primacy of insulin as the preferred pharmacotherapy for gestational diabetes compared with a sequential oral medication strategy that includes glyburide.” DECIDE testing metformin alone as a 1st line alternative! bmjopen.bmj.com/content/14/9...