Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...
Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
How do the basal ganglia turn what you see into what you do?
New preprint w/ @kenneth-harris.bsky.social, @flickerfusion.bsky.social & @carandinilab.net: we recorded across striatum, GPe & SNr in a Go/NoGo task. Striatum encodes which stimulus, GPe & SNr encode action. 🧵
biorxiv.org/content/10.6...
I wrote up something that's been in my head for a while: psychometric methods alone can't tell us what cognitive tasks and their indicators measure.
Correlating indicators across tasks is circular when constructs are defined by those same correlations.
osf.io/preprints/ps... 🧵1/3
Super excited to see the first paper from my PhD out! 🐭 Very satisfying to get to build an interpretable model of how the brain does a thing. A nice palette cleanser in the current sea of LLMs and deep ML.
Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...
I tracked every keyword in 22 years of Cosyne abstracts to map how computational neuroscience evolved — from Bayesian brains to neural manifolds to LLMs — and where it's heading next.
Adaptive integration of model-based and model-free strategies in human reinforcement learning of reachable space www.biorxiv.org/content/10.64898/2026.03...
How does the brain generalize past experiences without confusing memories? 🧠
Our lab's newest preprint reveals a fundamental division of labor between the cortex and cerebellum that solves this problem. (Check out the cortex-cerebellum video below! 👇) 🧵
🧠 New year, new preprint!
Why does motor learning involve multiple brain regions? We propose that the cortico-cerebellar system learns a "map" of actions where similar movements are nearby, while basal ganglia do RL in this simplified space.
www.biorxiv.org/content/10.6...
Excited to head to CCN @cogcompneuro.bsky.social next week! Come checkout a project I've been working on with @mariaeckstein.bsky.social using interpretable AI to understand flexible behavior in my talk on Thursday morning and poster on Friday evening: 2025.ccneuro.org/poster/?id=A...
Pleased to share our ICML Spotlight with @eberleoliver.bsky.social, Thomas McGee, Hamza Giaffar, @taylorwwebb.bsky.social.
Position: We Need An Algorithmic Understanding of Generative AI
What algorithms do LLMs actually learn and use to solve problems?🧵1/n
openreview.net/forum?id=eax...
Excited to share this project specifying a research direction I think will be particularly fruitful for theory-driven cognitive science that aims to explain natural behavior!
We're calling this direction "Naturalistic Computational Cognitive Science"
Our preprint is finally out! How can we understand the role of Behavioral Timescale Synaptic Plasticity in credit assignment? Does it fit into existing supervised and unsupervised learning frameworks? What theoretical gaps are still left unexplained?
www.biorxiv.org/content/10.1...
Our work, out at Cell, shows that the brain’s dopamine signals teach each individual a unique learning trajectory. Collaborative experiment-theory effort, led by Sam Liebana in the lab. The first experiment my lab started just shy of 6y ago & v excited to see it out: www.cell.com/cell/fulltex...
Congrats to the fantastic Jess P for her new paper! She compared how feature Vs outcome focussed agents learn to solve contextual inference problems. She found that you need a balance of both to learn these tasks - and that this mix recapitulates pfc and hippocampal activity in rodent tasks!
