Postdocs Nirbhik Acharya and @jessniblo.bsky.social worked awesomely together to show how disordered regions regulate folded domain interactions that affect UBQLN structure, dynamics, and binding. Illustrating the power of experimental (NMR, SAXS) and computational collabs on full-length proteins!!!
Excited to share our substantially updated manuscript, "Rational design of disordered proteins for systematic sequence-to-function investigation"! www.biorxiv.org/content/10.1...
Make sure to register and join us for the Anhydrobiosis Research, Tools & Techniques Webinar Series!
Happening each month beginning April 9, 2026!
Register here: walii.science/anhydrobiosi...
After over 2 years - our new preprint is finally out! “Rational design of disordered proteins for systematic sequence-to-function investigation”! www.biorxiv.org/content/10.1...
(1/7) New preprint, check it out! "Rational design of disordered proteins for systematic sequence-to-function investigation" www.biorxiv.org/content/10.1...
A great collaboration with our next door neighbors @castanedalab.bsky.social! We show how disordered regions 🍝 have hotspots that drive intramolecular interactions, regulating multi-domain protein topology and function. See more in Jess' post 👇
Ever wonder how IDRs and folded domains work together to control function? Using ubiquilins, multidomain proteins involved in protein degradation, we show in our new preprint that IDRs aren’t just linkers, but regulate ensemble and function. Read it here: doi.org/10.64898/202...
I am thrilled to announce publication of our new paper! We show transcription factor evolution in fungi is driven evolutionary turnover at two length scales. 1) Turnover of entire activation domains and 2) turnover of key residues within an activation domain. journals.plos.org/plosgenetics...
The @biophysicalsoc.bsky.social IDP Subgroup Postdoctoral Award honors outstanding Postdoctoral Fellows for their research accomplishments. APPLY by sending your nomination packet to idpsubgroupbps@gmail.com by Dec 15th! Find all information at: www.biophysics.org/awards-fundi...
I'm super excited to share the most recent work from my time in the lab of Thomas Boothby at the University of Wyoming, in collaboration with @shaharsu.bsky.social!
Read the paper here: www.cell.com/action/showP...
Now published in @cp-cellsystems.bsky.social - we look at the chemical features that make proteins tolerant to dehydration, and the functions these proteins fill. 🏜️🚱 tinyurl.com/bsfy56yt
All wiggly protein afficionados 🍝 - The IDP grodon conf is filling up fast. Please submit your registration ASAP! The conference takes place June 21-27 2026 in Les Diablerets, Switzerland, with an amazing speaker lineup! Details: tinyurl.com/yfm5jsxt @idpgrc.bsky.social @idpseminars.bsky.social
Really happy we could be a part of this work!! Congrats!
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
🧬Next up: Mustafa Mir in the Transcription and Chromatin Regulation session! His lab uses live embryo & single-cell single-molecule tracking to reveal how IDRs guide transcription factor target search & specificity - shedding light on gene regulation in development. @mirlab.bsky.social
Promotional image of a plant growing in the desert for the First Annual WALII Symposium: Exploring Life Without Water. The graphic includes the date and time of the event and information on how to register.
The First Annual Virtual WALII Symposium: Exploring Life Without Water is ONE WEEK AWAY! 🗓️💧
Register now to join us on November, 18!
www.walii.science/virtual-symp...
🚨🚨The GRC on Intrinsically Disordered Proteins #IDPs is back!! 🍝🧵🏔️Join us for cutting-edge IDP science, great discussions, and mountain views 🌄🍝
📅 June 21-26, 2026 | Les Diablerets, Switzerland
👉 Details & registration: grc.org/intrinsicall...
🚨The 2026 IDP GRC Program is LIVE! 📣
Check it out: www.grc.org/intrinsicall...
We’ve got an incredible speaker lineup! 🌟
Over the next few weeks, we’ll be highlighting some of them and giving you a sneak peek at the exciting topics they’ll be covering. Stay tuned!
🎉Excited to announce that Dr. Rebecca Berlow @berlowlab.bsky.social
will speak in the “Disorder in Pathogens” session at #IDPGRC2026!
The Berlow lab uses solution NMR and biophysical approaches to uncover how IDP sequence, dynamics & function drive transcriptional regulation.
🖥️Next up: Jeetain Mittal in the Material Properties of IDPs and Condensates session! His team uses multiscale simulations to uncover how sequence-encoded interactions in IDPs govern conformational transitions & condensate behavior - informing neurodegenerative research. @mittalgrouptamu.bsky.social
📢 Abstract deadline Nov 1!
Join us at the FASEB Conference on Biomolecular Phase Transitions (Jan 11–15, 2026, Melbourne, FL), showcasing cutting-edge research on condensates in health & disease, and therapeutic frontiers.
~30% talks from abstracts!
events.faseb.org/event/480194...
Thanks @elevylab.bsky.social for a fantastic writeup!!
Can't wait to see you all there!!
The power of collaborations! With @shaharsu.bsky.social, his PD @jessniblo.bsky.social and CALVADOS3 (thanks to @lindorfflarsen.bsky.social ) we show how STI1 (red) may engage with sequences that match transient helices within IDRs of Ub-binding shuttle protein Dsk2 www.biorxiv.org/content/10.1...
Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers!
Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
📢 Excited to share our research with @shaharsu.bsky.social & @mvstaller.bsky.social on how activation domain (AD) structure affects gene expression! 🧬 TLDR: HIF-1α & CITED2 ADs suggest ensemble dimensions may regulate transcription in unique ways.
www.cell.com/biophysrepor...
🧵 Highlights:
Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models).
www.biorxiv.org/content/10.1...
The STARLING has landed - excited to share new work from @bornanovak.bsky.social and @jefflotthammer.bsky.social in what is also Borna's first Bluesky post!
If you're at BPS, I'll be speaking about this this afternoon in IDP SG, and Borna and Jeff both have posters (Sunday B112 and Wed B152).
Announcing the Biophysics Week IDP Trainee Symposium on March 27 at 12pm CT hosted by @idpseminars.bsky.social & The BPS IDP Subgroup! Join via Zoom for talks by talented grad students & postdocs. Abstract submissions are open! See flyer for more details! #BiophysicsWeek @biophysicalsoc.bsky.social
