Can "glitches" in how the heart processes sugar lead to dangerous arrhythmias? 🍬➡️💔

Our new study now in preprint shows that glycolytic dysregulation at the PFK nexus is enough to cause electrical instability in the heart. Check out our findings here:

The effect of enhanced glycolysis on cardiac aging - GeroScience Cardiac aging is associated with metabolic changes, including an increased reliance on glycolysis, and an increased susceptibility to cardiovascular diseases. This study explores the relationship betw...

New publication from our lab with lots of contributions from my great @am-omrf.bsky.social colleagues. We examined the effect of enhanced glycolysis on cardiac aging. Read the full article here:

link.springer.com/article/10.1...

Grateful for the award! A major thanks to the Multiplexing Protein Analysis Core and folks at @am-omrf.bsky.social (like @benjaminfmiller.bsky.social) who were instrumental in gathering preliminary data for our NIH grant proposal.

Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice - GeroScience Ovarian aging is characterized by declines in follicular reserve and the emergence of mitochondrial dysfunction, reactive oxygen species production, inflammation, and fibrosis, which eventually result...

Recent paper from the Stout lab reveals Canagliflozin, a diabetes drug, may delay ovarian aging by preserving follicular reserves and improving mitochondrial function. Could this hold promise for delaying menopause and systemic aging in women? 🧬
link.springer.com/article/10.1...

Mechanistic studies of PFKFB2 reveals a novel inhibitor of its kinase activity The 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB) family of proteins are bifunctional enzymes that are of clinical relevance because of their roles in regulating glycolysis in insulin se...

I'm excited about this- in this study we identified a new inhibitor of PFKFB kinase activities and we're hopeful for future applications.

www.biorxiv.org/content/10.1...

Check it out ⤵️
Several of our scientists and outstanding trainees are on Bluesky.
go.bsky.app/5oUbpNy

Very cool! Congrats and thanks for referencing our work on MPC2 acetylation in the heart!

O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder Matheny-Rabun and colleagues discover that O-GlcNAc modification of rate-limiting enzymes within the N-glycosylation pathway impacts their function, drawing a connection between two spatially separate...

O-GlcNAc modification of enzymes within the N-glycosylation pathway impacts their function, revealing a connection between these two distinct glycosylation pathways.
www.cell.com/cell-reports...

Sooo… with all the new users and resources, and without ads, what’s the business model on Bluesky? 🤔

Where did we get our profile picture? The foyer at OMRF has an amazing artistic cell representation with inlaid marble #mitochondria

Isolated Mouse Adult Cardiomyocytes Display Minimal Mitochondrial ATP Demand and Maximal Reliance on Glycolysis

I would be happy to be added!

Dr. Sue Bodine presented updates of the MoTrPAC at today’s 21st Annual Harold Hamm Diabetes Research Symposium #MoTrPAC

OMRF discovers new chemical link to Alzheimer’s Findings may explain mood changes that precede disease

How’s this for a first post?
New publication in Nature Communications about the role of dopamine in Alzheimer’s disease⤵️
omrf.org/2024/11/12/o...

#1 on App Store

Oklahoma has the second-lowest average ACT scores in the nation. See the data Nearly 50,000 Oklahoma 2024 high school graduates took the ACT, an Oklahoma graduation requirement, resulting in an average composite score of 17.6.

Are there a lot of Bible questions on the ACT?

www.oklahoman.com/story/news/e...

This is a picture I took earlier this week 😀

Bluesky - Wikipedia

I was wondering how Bluesky gets away with being so similar to Twitter. It’s because it was a Twitter side project. en.m.wikipedia.org/wiki/Bluesky

In a world full of Twitters, be a Bluesky.

Humphries lab, represent. Grad student, Kylene Harold, presenting her work on our PFKFB2 knockout mouse. 🫀

Two foxes 🦊 🦊, one stray cat 🐈. Everyone gets along with just a little suspicion.

A cool moon halo tonight. 🌖 😇

First post! How about a picture of our backyard gray fox. 🦊 They’re finding a niche in urban areas.