📣 Bold science alert! We're thrilled to announce our latest awardees who are pushing the boundaries of research in aging, regeneration, and bacterial resilience. bit.ly/HFAwardees
Hear from the #HFScouts who championed these talented scientists👇 in our 🧵: 1/
Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
Incredible chance to learn about genetics, from the fundamentals to the latest science. I attended this course when I was a PhD student in the 90s and have lectured in it for the last dozen or so.
And science aside, there's nowhere better to be in late July than Bar Harbor, ME. See you there.
I’ve never felt unsafe in this bougie neighborhood a day in my life. This is a 25 mph zone, full of fancy bars and restaurants, a curling club, salons, boutiques, and one of the busiest coffee shops around. They are doing their damndest to wreck everything here.
Another charter member of the "Branch Covidians"...
The damage these idiots are doing both with specific issues under consideration and future operations is breathtaking (literally).
Central high school just walked out, marching on the Capitol
Sounds like they have a band with them
Simply outrageous!
Fantastic opportunity for undergraduates pursuing summer research experience! @hhmi.org
Me in front of the ABRCMS sign
16 (! What?) years ago I went to my first ABRCMS and was welcomed and encouraged to pursue my scientific dreams. I met folks that provided direct feedback on my graduate school applications and served a pivotal role in my career. I am honored return and give back again as faculty.
#ABRCMS2025
How do cancer cells use the nutrients to grow and how can that knowledge lead to better care? Gregory Ducker, PhD, studies the metabolism of cancer. @duckerlab.bsky.social aims to uncover new ideas for future therapies & ways to make current treatments even more effective. @uofubiochem.bsky.social
Updating my LEGO White House
this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result
www.science.org/doi/abs/10.1...
In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator.
Forever grateful to past and present members of my lab for helping me accomplish this dream.
UPDATE: The pause was scrapped Tuesday evening after intervention by top White House officials. www.wsj.com/politics/pol...
Presumably this will lead to labs closing as paylines are abruptly lowered. I’d have to imagine it’s unstated but is that the point?
We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
www.nature.com/articles/s41...
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy
DM for more info. See our recent preprint on biorxiv for details on project area and to learn more about team. www.biorxiv.org/content/10.1...
🚨Postdoctoral position available now! 🚨We have an immediate fully funded position available in cardiac metabolism. We are looking for a highly motivated person to lead our animal model work in oxidative metabolism in heart! Pay is competitive with benefits offered and you get to live in Utah. 1/2
🚨 There’s a lot of horrific news out of Washington right now—but you might have missed this: Senate Republicans just introduced a plan to sell off 120 million acres of our public lands.
Let me break down what’s in the bill and why it’s a full-scale land grab. 🧵
![[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreid7lnvd7afmasx3nxi6anxmyhbatpaw54za3kiw3eaoclrf722faq)
[Person with ponytail wearing lab coat hands balloon to another person in front of a springboard, a magnet hanging from above, and then a target] PERSON WITH PONYTAIL to Person 2: Rub this balloon against your head, then go jump past that magnet toward the target on the wall. [caption] Before the bathroom scale was invented, the only way to weigh people was mass spectrometry.
Mass Spec
xkcd.com/3094/
Overall our study reveals that disruption in gluconeognesis can signal to pancreas and that loss of autophagy that occurs in obesity or liver damage may also be affected pancreatic hormone secretion and regulation. Thanks to all the co-authors on this great study. 5/5
High glutamine in blood stimulates alpha cell proliferation and glucagon secretion. But in livers without autophagy, no gluconeogensis can occur! This broken feedback loop results in a state of hypoglycemia with hyperglucagonemia. 4/n
What happens to gluconeogenic substrates? They build up in blood- glutamine and alanine are significant increased when autophagy is lost. We use clamps to show that loss of gluconeognesis also reduces glucose uptake systemically. 3/n.
Autophagy has been shown to be important for glucose regulation- but a detailed physiological understanding was lacking. Here we show loss of liver autophagy leads to hypoglycemia due to loss of gluconeogenesis 2/n
New paper alert! Huge congrats to my graduate student Jesse Velasco on his first author publication in physiological reports. physoc.onlinelibrary.wiley.com/doi/10.14814...
We @morgridgeinstitute.bsky.social, in partnership with
@bmolchem.bsky.social , are looking for a great new metabolism researcher to join our @morgridgemeta.bsky.social team. Please see ad below and send along to your colleagues!
morgridge.org/job-posting/...
So much healthy food discourse is disguised versions of "have you tried not consuming a quart of oil daily"
i would say the modal opinion among the media-political elite is that trumpers are basically correct that our government/elite universities have been taken over by woke ideology/too many minorities and women and that trump is providing a welcome corrective even if it goes too far
