These results indicate that microglia markers have different potential for neuropathological analysis, with HLA-DR and CD68 reflecting immune activation and response to tissue damage

Disease Association: High levels of CD68-positive microglia are found in neurodegenerative diseases (ALS, AD) and white matter lesions.

1) Dr. Felipe Correa da Silva shared more info about the first 10 brain autopsies from the Netherlands.

In this new thread, we made a brief summary of his presentation.

It just fascinates me that there is increased CD68 but the microglia are senescent. I can't figure it out.

Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions Deep subcortical lesions (DSCL) of the brain, are present in ~60% of the ageing population, and are linked to cognitive decline and depression. DSCL are associated with demyelination, blood brain barrier (BBB) dysfunction, and microgliosis. ...

The immunoreactive profile of CD68 increased in a stepwise manner from control white matter to normal appearing white matter to Deep subcortical lesions. This correlated with a shift from small, ramified cells, to larger, more rounded microglia.

pmc.ncbi.nlm.nih.gov/articles/PMC...

Oh, I should have looked a little further.
"CD68 plays a critical role in promoting phagocytosis; however, the function of CD68 in tumor immunity and prognosis remains unknown."

Are you sure this means increased phagocytosis?
I can't figure out why in cancer inncreased CD68+TAM is linked to tumor progression.

It seems the test has shown that bluesky will not list Sascha Riley as trending. I clicked on 2 of the words that are trending, and most of the posts didn't even have the word in the post.

Some kind of crime happened at the Newtown WaWa, the perpetrator fled through the woods. We live nearby and were notified by police today at about 1:30 PM. Let me know if you can find out when/if the person they are looking for is apprehended. Thank you

The GOP has the majority in the House and Senate. How would the Democrats be able to impeach him if the GOP Congressmen don't want to. Her spine needs some educating on how things work.

Bluesky does have some bot/troll accounts. But it's much better here than the other place.

That is a good video.

I hope so.

Do you not understand what President Biden did for our country?

Please, no ageism, either.

Who are the Democrat politicians that feel threatened by rising class consciousness?

Yes, that makes sense.

Anti-influenza virus effect of aqueous extracts from dandelion Human influenza is a seasonal disease associated with significant morbidity and mortality. Anti-flu Traditional Chinese Medicine (TCM) has played a significant role in fighting the virus pandemic. In ...

We found dandelion could inhibit the influenza virus infection. We further identified the inhibition of viral polymerase activity and the reduction of the virus nucleoprotein (NP) RNA level contributed to the antiviral effect. pmc.ncbi.nlm.nih.gov/articles/PMC...

Dandelion extract inhibits SARS-CoV-2 in vitro An exciting new study describes a specific inhibitor of the SARS-CoV-2 found in an extract of the common dandelion that could provide a new and fruitful avenue of drug research.

The results also showed that the dandelion extract blocked viral entry into cells, using a pseudotyped lentivirus expressing the SARS-CoV-2 spike, by about 85% at a concentration of 20 mg/ml, and by 70% at half this concentration.

www.news-medical.net/news/2021032...

That decision is like saying an attorney can't bring a case because he's not the one affected.

Luke, do you process them?

🔥 AMAZING.

Today, the Baltic states disconnected their power grids from that of Russia.

It’s taken years of prep. What a moment.

Nearly $7 million has been “apportioned” over the past week to cover DOGE-related expenses.

Do you know what type of badge this is? I can't tell if it has the same insignia as the one on his cap and arm patch.

This is not a U.S. Marshal, Federal Protective Service, or any other federal law enforcement officer. This is a private security guard from Triple Canopy. He has no authority to block members of Congress who have oversight of the EPA from entering the building.

Sounding cranky is okay

In Berlin

bsky.app/profile/kyle...

I can relieve your shock by informing you that that's not true.