What if AI could invent enzymes that nature hasn’t seen? 👩🔬🧑🔬
Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design
📝 Blog: disco-design.github.io
📄 Paper: arxiv.org/abs/2604.05181
💻 Code: github.com/DISCO-design...
I'm excited to announce some major updates to our ProteinEBM paper with Chenxi Ou @sokrypton.org!
Finally out! Miriam's 1st, 1st author article!
1st last author paper as a group leader! A work that started 3 years ago when I was a postdoc in Alfonso Valencia's group 🥹
doi.org/10.64898/202...
Thread🧵
1/6
Thrilled to announce our updated preprint on the CANVAS method for de novo enzyme design, in collaboration with @birtehoecker.bsky.social. We show how CANVAS builds custom lids onto minimal TIM barrels, transforming them into efficient catalysts.
www.biorxiv.org/content/10.1...
This petition wants contributing to Free Software to be legally and officially recognized as volunteering in Germany on the same level as youth work or ambulance service:
www.openpetition.de/petition/onl...
You don't need to pay Apple or start a new subscription to unleash your creativity. We asked creatives what free software they use to get the job done and here are their picks.
kde.org/for/creators/
A graphical thread 🧵 ▶️
#creativity #design #audio #editing #art
PyPI website with pdbfixer researched. Three packages below that are forks of pdbfixer "to be able to pip install it".
Also it seems a few people already had this problem and found some workarounds 😂
Could it be that there was a previous package called this name that has been deleted? PyPI doesn’t allow for redundancy, so the name would be blocked. However, PyPI is case sensitive: it should be possible to do a PDBfixer package (so "pip install PDBfixer" instead of "pdbfixer")
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
Been excited about this one for a while! What would you do with a new alphabet and the wealth of protein sequence bioinformatics at your disposal? We're also around at #EMBOComp3D Heidelberg and MLSB Copenhagen this week to discuss
New 🧬✂️ pre-print! We show that paired prime editing can efficiently generate large deletions — even >1 Mb — with high precision and at scale. We use this to perform the first pooled prime deletion screen across the human genome.
🔗 biorxiv.org/content/10.1...
A short thread (by Juliane Weller)👇
📣New CRC 1357 Publication: The Key to Enzymatic Degradation of Polybutylene Terephthalate (PBT): Influence of Semicrystalline Properties on Degradation
doi.org/10.1002/cssc...
📣New CRC 1357 Publication: Congrats to Onur Turak, Protein Design @birtehoecker.bsky.social, & co-authors and their new article: A third type of PETase from the marine Halopseudomonas lineage
Structure & sequence features of type III PETases reported!
onlinelibrary.wiley.com/doi/10.1002/...
Explore PDB-themed #Inktober #SciArt images from structural biologist Irina Bezsonova from (2023 and 2022)
This database aggregates over 1 millisecond of unbiased MD simulations across >700 systems, including mAbs and protein-ligand complexes dynarepo.inria.fr However...
Nobody is commenting on this little nugget from Fig 1?
Exclusive: Famed protein structure competition nears end as NIH grant money runs out | Science | AAAS www.science.org/content/arti... 🧪
Physics-based design of efficient Kemp eliminases
@lynnkamerlin.bsky.social
www.nature.com/articles/s41...
🚧Open PhD position!🚧
Do you think protein machines are super cool 🤖? Would you like to design them using Nobel prize-winning methods? ➡️ Apply and choose topic 12.
www.ki.si/en/news/tend...
Position is fully funded for four years. One week left to apply.
An example carborane molecule represented in Coot - 6yzn
Coot with anisotropic atom probability turned up to 100% for 5vof
Coot Release 1.1.16
o FEATURE: Local B-factor display
o FEATURE: Built-in logging (started) - view it by clicking the "Log" button
o FEATURE: Anisotropic probability radius scaling
o CHANGE: Boron atoms are now pinky-beige (like Jmol)
#coot
We (@sacquin-mo.bsky.social, Chantal Prevost and I) teamed up with @etiennereboul.bsky.social and @ataly.bsky.social to design a parallelized MDAKit implementation of the Proteic Menger Curvatures. Local protein dynamics and backbone flexibility have never been easier and faster to compute 😁
Great talks & discussions at the 76th Mosbacher Kolloquium last week - in particular fantastic Lynen Lecture by Tanja Kortemme @kortemmelab.bsky.social and Eduard-Buchner award lecture by Dorothee Kern! And great to see so many old and new friends. @gbmev.bsky.social
Birte Höcker opens the 76. Mosbacher Kolloquium. We look forward to learning a lot about AI and the (r)evolution of protein folding in the next three days!
Feodor-Lynen-Lecture delivered by Tanja Kortemme (UCSF) at the Mosbacher Kolloquium. Congratulations!
Had a great time at the Mosbacher Colloquium 2025—fantastic science, engaging discussions, and lots of inspiration. Shoutout to Anna and Hubert for taking the stage and board with their work!!!
GIMP 3.0 is released!!!! LET’S GOOOOO! ❤️🔥
From octopuses to snails, the complicated molluscan family tree has now been mapped in unprecedented detail, researchers report in Science.
This includes sequences for 13 new complete genomes from across the phylum. scim.ag/3DrGAkg
How do distal mutations contribute to enzyme catalysis?
Our new study, in collaboration with @thompson-lab.bsky.social, Marc Garcia-Borràs, and @ferranfeixas.bsky.social, reveals how they optimize structural dynamics & local electric fields to drive the catalytic cycle. 🧵👇
Pro Tip: this is the day you can ask your significant other "Will you be my Sam?"
