Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study Background and Aims Alcohol-related liver disease (ALD) is a major cause of mortality and disability-adjusted life years. It is not fully understood why a small proportion of patients develop progre...

First first author article for Eemeli Puhakka published!

We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics

doi.org/10.1111/liv....

#metabolomics #alcohol

The main benefit of ALBI is better defining prognosis amongst compensated CPT-A patients - if needing albumin then I'd say probably not the score to use.

A close up of a viral of thiamine hanging as a Christmas tree bauble

A Christmas tree upon which there are many vials of thiamine hanging as baubles

Merry Christmas to all on #liversky

Enhanced liver fibrosis (ELF) score predicts hepatic decompensation and mortality - PubMed Primary care pathways for suspected liver disease are increasingly common and often lead to increased specialist hepatology referrals for fibrosis assessment. This study, using clinical follow-up for ...

>13.0 😲
High risk of 90 day decompensation and 12 month mortality - pubmed.ncbi.nlm.nih.gov/38826498/

Hepatocellular carcinoma risk in sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe - PubMed Sub-Saharan African ethnicity has been associated with a higher risk of hepatocellular carcinoma among individuals with chronic hepatitis B. In this international multicenter cohort study of sub-Sahar...

Emails this evening between colleagues in Scotland about HCC surveillance in HBV patients from Sub-Saharan Africa, many performing surveillance at a young age but questioning need (if no advanced fibrosis) in light of pubmed.ncbi.nlm.nih.gov/37898348/ what are others doing? #liversky #hepsky

New people added to the PSC Starter Pack
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‘At 31, I was told if I didn’t stop drinking, I could die’ BBC journalist Hazel Martin was told she had liver fibrosis and must go teetotal or she could die.

www.bbc.com/news/article...

Nice to see Debbie Shawcross (not on here yet!), @drgautammehta.bsky.social and others really highlighting this issue on various BBC platforms today!

#LiverSky
@adhanda.bsky.social
@aleksanderkrag.bsky.social

Very excited to be on @bbcnews-uk-rss.bsky.social Panorama tomorrow, talking about the hidden harms of binge drinking @stsucl.bsky.social #alcohol #livertwitter #PublicHealth

Add me please Phillipa #NoHep

Pleased to see the publication of our paper showing effective management of alcohol withdrawal syndrome in patients with coexistent alcohol-related liver disease using GMAWS.
Great contributions by our medical students: Stroma Harcombe, Lujine Ibrahim, Georgia Smith and Alex Doyle.
t.co/fEjeZChSVI

Stunning!

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Yes!
And low qHBsAg patients are not the majority in our clinics… many left behind

Reflecting on the raft of early phase HBV trials at #TLM24. Good to see new compounds with different MOAs moving forward- however so many of the inclusion criteria were for subjects with low qHBsAg who would have a good chance of S loss with just stopping their NA 🤷🏻‍♂️ #liversky

Lismore lighthouse, off the west coast of Scotland

Excellent study: the 40mg prednisolone for 28 days has been ripe for challenging for a long time now. Dose and duration established only by historical quirk rather than evidence. Need to assess targeted (I would argue NLR rather than severity based) tapered/short duration treatment.
#liversky

Management of primary sclerosing cholangitis: Current... : Hepatology Communications and colorectal cancer. Medical therapies are lacking, and this, in part, reflects a poor grasp of disease biology. As a result, current management is largely supportive, with liver transplantation an ...

The best review on PSC that I have read

journals.lww.com/hepcomm/full...

🫡 @autoimmuneliver.bsky.social
#medsky #liversky

Great to see real world data for GLP1 agonists in MASLD/MASh from the TARGET-NASH Cohort. 10% of cohort received > 1 year. Non users 1.69 RR of decompensation and 2.38 RR all cause mortality #liversky #tlm24

Just updated

Keep it coming

Here! But haven't quite got into the blue sky habit yet!

Glad to be on #medsky - any refugees from #livertwitter made it across yet?