We are recruiting sewersheds for an expanding project. Basically, we want to learn everything that can be learned from wastewater.
Read on if you are interested.
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Dr Neil Stone talking about social media & medicine in Vienna at ESCMID Global.

Now it’s @drneilstone.bsky.social talking about social media and medicine. “Bluesky is the dominant platform now.”
He said it. We will get him over to Bluesky for good! 💪🏼😉😁
#ESCMIDGlobal
#IDSky #MedSky

🧧🧧🧧🧧 So another exciting finding for the weekend before I go on vacation.

*FFPE Ligation Sequencing for ALL!*

For a long while it was thought that ligation (i.e. native DNA) sequencing on @nanoporetech.com was difficult, if not impossible.

Congrats Hasindu and Nanopore Garvan team. This is an exciting development. I remember asking myself how AS might be used when it was first released. You have truely answered this 🙌🎉

photograph of an internal house door with a little window above. Sam can be seen waving through the window. a little breakfast is on a tray outside the door.

happy nanoversary to me! i had totally forgotten that three years ago today i started my nanopore adventure by testing positive for covid and isolating in my office

A long time coming, but our @nanoporetech.com P2Solo is finally running. Time to dive deeper into the messy unknown, hunt down mysterious pathogens, and maybe even find some shiny new viruses. Let's do this. 🦇🐓🧪🦠🧬🔬 #Nanopore #VirusHunting #Science #OneHealth #Genomics

"right now it seems to me that the competition can do most of the things that Oxford Nanopore can"

* cough *

- minimum setup cost of less than $10,000
- minimum run cost of less than $100
- minimum turnaround time of less than 1h
- RNA methylation
- reads longer than 100kb
- sequencing in space

SquiggleNet: real-time, direct classification of nanopore signals - Genome Biology We present SquiggleNet, the first deep-learning model that can classify nanopore reads directly from their electrical signals. SquiggleNet operates faster than DNA passes through the pore, allowing re...

There have been a few papers on this subject. eg SquiggleNet. Sidestepping the effort needed to basecall makes sense in certain situations where quick results are beneficial, such as pathogen ID. Could this become the basis of a real Tricorder?
genomebiology.biomedcentral.com/articles/10....

This is a curious one - real time hashing of raw nanopore signals, building up to a whole de-novo assembly based on the 'squiggles'. This skips basecalls entirely. What do people think about this approach?

💻🧬

Opinion | Covid’s Deadliest Effect Took Five Years to Appear (Gift Article) What once belonged to all of us now belongs to corporations.

“Back then, the overwhelming public sentiment was: never again. Today, it seems: never what?”—Siddhartha Mukherjee
Exceptional essay
Gift link

www.nytimes.com/2025/03/10/o...

WHO issues starkest warning yet on fallout from U.S. withdrawal of aid for global health Breaking: The WHO issued its starkest warning yet on the consequences of the abrupt cessation of U.S. global health funding, saying it is threatening to reverse years of progress worldwide.

#Breaking - WHO issues starkest warning yet on fallout from U.S. withdrawal of aid for global health

#Spring has sprung

Readers of articles like these need complicated concepts presented in an easy to understand format otherwise they will likely not continue beyond the headline. Thinking in terms of features, advantages and benefits is useful and straight forward, and is probably not directed at professionals

🇺🇦 Slava Ukraini 🇺🇦

BTW, we have a website that will display all of this data that we are planning to launch very soon. Stay tuned.
5/5

If you like building tools for scientists like this, come join us! plasmidsaurus.com/careers

Photo of author wearing baseball cap lettered “Genomics & Bioinformatics Service” with AGBT sponsor list on pillar behind

Overdue for my annual #AGBT haberdashery communique

This year I’m sporting this wonderful cap @biomath.bsky.social gifted me last year.

There might be a few more around, but if you accidentally mistake another for me - any friend of Charlie’s is an interesting new contact! 🧬🖥️

De tuin vindt dat het voorjaar is

Roche Ripple Predictions

My take on how Roche SBX will roil the sequencing landscape

omicsomics.blogspot.com/2025/02/roch...

🧬🖥️

Albert, Are they doing live demo's like Nanopore?

m.genome.cshlp.org/content/earl... Matt Loose in Nottingham publishes a method for Adaptive Sampling with Oxford @nanoporetech.com sequencing.

That peak? The one in 1962/1963? That was when the United States of America spent 2.5% of GDP in federal dollars on SCIENCE.

That peak in spending gave us our entire economy as we currently understand it. Composites, integrated circuits, lasers, advanced fabrics, biotech, etc... Time to reinvest.

This is the thing about basic science…

You never know where it will lead, and you cannot presuppose what commercial product comes out of it.

They don’t tend to award Nobel Prizes for translational science. They award them for basic, often exploratory science.

Thanks Shawn, re speed, obviously the sequencing is only part of the whole process. Do we have any idea of the prep time of the polymerase/snip stage?

EIT is buying shares that are being sold on market by various Quant based hedge funds who are positioned short, ie they think the ONT sp is going down.

The total short position is approx 3.63% as at Friday 14/2/2025

ONT Share price is finding support [buyers] at 130
The rising 200SMA is at 129.2

Delphi Asset Management is owned by and holds investments for Oracle Corp.

Once completed, the Ellison Institute of Technology will focus on curing cancer and researching the illnesses associated with aging.

Larry Ellison has been a long time supporter of ONT, first holding as a private investor [before the listing] through Oracle. In addition to Oracle he holds ONT shares via EIT Oxford.

Delphi AM, approx 3.75% or 35,294,117
EIT approx 8.019100% or 76,585,244

Total 11.77% or 111,879,361

Hi Albert, research RNS notices named TR-1's.
These are holding notices for UK listed co's. UK holders have to notify long holdings above 3%, foreign holders notify at 5%+. Further TR-1's are required when holdings cross each 1% +/- threshold boundary.

BRUH

My plasmid samples arrived at 8am on a ***saturday***

Delivery to data in 50mins?!

Roche emerges from the Lazarus pit Is Roche going to "knock it out of the park" or "jump the shark"? Everyone I know is excited, even if many of them are sceptical, about the Feb 20th webinar and what we will learn about SBX. Alex Dick...

Hi everyone on Bluesky working in #genomics #NGS. Today is Valentines day. How many of you are more excited about Feb 20th?!

Read my new post on Enseqlopedia Roche emerges from the Lazarus pit to take on Illumina

enseqlopedia.com/2025/02/roch...