Distinctive DNA sequence features define epigenetic longevity of inflammatory memory Tissues harbor memories of inflammation, which heighten sensitivity to diverse future assaults. Whether and how these adaptations are sustained through time and cell division remain poorly understood....

Our paper is out in @science.org describing how epithelial cells retain long-term inflammatory memory
www.science.org/doi/10.1126/...

Very cool study uncovering how stem cells pass on imprints to progeny in vivo from. @thefuchslab.bsky.social @danapeer.bsky.social drawing from beautiful work done by @grothlab.bsky.social on epigenetic inheritance and the mechanisms of information transfer through cell division.

A 180 degree turn en route to crafting a scientific career that never goes stale - Nature Cancer Elaine Fuchs is renowned for her research in skin biology, stem cells and associated disorders, including cancers and inflammation, and has published over 380 articles. She received her PhD in biochem...

In this piece from @natcancer.nature.com, Rockefeller's Elaine Fuchs (@thefuchslab.bsky.social)—renowned for her research in skin biology, stem cells and associated disorders, including cancers and inflammation—recounts her scientific career.

Yearly Fuchs lab picnic 🧺

The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury Novak et al. discover that dietary serine impacts whether hair follicle stem cells (HFSCs) prioritize hair growth or skin repair after injury. HFSCs gauge metabolic stress using the ISR and accelerate...

New paper alert! We report in @cp-cellmetabolism.bsky.social how serine regulates stem cell fate in physiology and upon wounding.
Good work, Jesse and collabs!
www.cell.com/cell-metabol...

Fantastic talk by @thefuchslab.bsky.social on the highly anticipated work on inflammatory memory with aging… congratulations to @chris-cowley14.bsky.social @rajsajjath.bsky.social et al

Humans’ Wounds Heal Much More Slowly Than Other Mammals’ We naked apes need Band-Aids, but shedding the fur that speeds healing in other mammals may have helped us evolve other abilities.

Rockefeller's @thefuchslab.bsky.social weighs in on new research showing that human wounds take more than twice as long to heal as wounds of any of the other mammals in the @nytimes.com:

Very timely and insightful review from @thefuchslab.bsky.social on epithelial stem mechanobiology and the role of mechanics in controling epithelial tissue (morpho)dynamics in development and cancer! A must read for anyone in the field 👇!

And the #AACRFellows have elected Elaine V. Fuchs, PhD, FAACR, of @RockefellerUniv.bsky.social as the next President of the AACR Academy. www.aacr.org/professional...

Congratulations, @thefuchslab.bsky.social!

Great news! @greatysp.bsky.social @jorgealmagro.bsky.social

Congratulations to @jorgealmagro.bsky.social and @thefuchslab.bsky.social as well!! 🎊🎉🥳🥳 @rockefelleruniv.bsky.social @hhmi.bsky.social

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

New #Review! 🥳

@jorgealmagro.bsky.social, @thefuchslab.bsky.social et al. discuss the role of stem cell mechanics during developmental processes and what happens when the mechanics of the stem cell niche are disrupted in cancer.

👉 go.nature.com/3EsJzJx

#StemCells #Mechanobiology #Cancer

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

Very happy to see our review out in @natrevmcb.bsky.social!
Here we discuss how stem cells exert forces to sculpt tissues in development and homeostasis, and how stem cell mechanics go awry upon malignant transformation. Read it here 👇
www.nature.com/articles/s41...

Shaping epithelial tissues by stem cell mechanics in development and cancer - Nature Reviews Molecular Cell Biology Adult stem cells self-renew and differentiate to build, maintain and repair tissues. This Review discusses recent insights into the contribution of mechanical forces produced by epithelial stem cell a...

Our first 2025 paper!
We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer.
Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏
www.nature.com/articles/s41...

Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding early career scientists!

HHMI Names the 2024 Hanna Gray Fellows | HHMI The cohort includes early career scientists working in research areas ranging from treatment-resistant cancers to how animals evolved to live on land. The HHMI Hanna H. Gray Fellows Program provides e...

Thrilled to announce that two Rockefeller scientists have been named @hhmi.bsky.social Hanna Gray Fellows!

Congratulations to @paigearnold.bsky.social of the
Marraffini lab and Jim Castellanos of @thefuchslab.bsky.social and Weill Cornell Medicine on their awards!

Circadian clock communication during homeostasis and ageing Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...

🧪 ✍️ Please check out our new review on intercellular and interorgan communication between circadian clocks ⏰🧬 out today in Nature Reviews Molecular Cell Biology 🎉
@natrevmcb.bsky.social
! Here is the SharedIt link for free access: rdcu.be/d5ppE

Stay tuned for more exciting news on stem cell biology, cancer, immunology, and more in 2025! 🥳 🎉

And last but not least, we discuss the molecular and cellular diversity of squamous cell carcinomas in @genesdev.bsky.social
m.genesdev.cshlp.org/content/earl...

Stem cells tightly regulate dead cell clearance to maintain tissue fitness - Nature The spatiotemporal activation of phagocytosis by hair follicle cells is orchestrated by lipids released from surrounding apoptotic cells and retinoids released by healthy cells.

Hair follicle stem cells act as non-professional phagocytes to regulate the hair cycle. Follow the link to our paper in @natureportfolio.bsky.social
www.nature.com/articles/s41...

CD80 on skin stem cells promotes local expansion of regulatory T cells upon injury to orchestrate repair within an inflammatory environment In skin injury, the inflammatory environment can impact repair mediated by skin stem cells. Luan, Truong, Vuchkovska, et al. show that hair follicle stem cells migrate into the wound, activate immune-modulatory molecules, and expand extrathymic regulatory T cells to facilitate the resolution of neutrophil responses and the initiation of wound repair.

Skin stem cells express CD80 and drive regulatory T cell expansion to aid regeneration upon injury. We published our discovery with @phoenixmiao1010.bsky.social in @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices Retinoic acid dictates whether and when bipotent adult hair follicle stem cells pursue one cell fate versus another.

Vitamin A regulates lineage plasticity in hair follicle stem cells upon injury. Read our paper in @science.org
www.science.org/doi/10.1126/...

Beyond genetics: driving cancer with the tumour microenvironment behind the wheel - Nature Reviews Cancer In their Review article, Fuchs and colleagues discuss how a single or a few mutations in adult cells can lead to invasive cancers without a high mutational burden, demonstrating that non-genetic ...

Cancers may arise in tissues with a low mutational burden. It’s up to the microenvironment! We discussed this in @natrevcancer.bsky.social
www.nature.com/articles/s41...

2024 was a year of exciting discoveries and scientific discussions! A thread 🪡 of this years’ publications from our lab 👇🏼

Getting our Bsky started with our yearly Holiday picture! 🌟
Happy Holidays from the Fuchs lab!