Bismuth-photocatalysed Heck-type coupling with alkyl and aryl electrophiles Nature Catalysis, Published online: 31 October 2025; doi:10.1038/s41929-025-01438-yThe Heck reaction is widely used in modern organic chemistry. Here the authors provide an alternative approach to common transition-metal catalysis, leveraging access to Bi(II) species thanks to bismuth’s photophysical properties.

New online! Bismuth-photocatalysed Heck-type coupling with alkyl and aryl electrophiles

Ambiphilic cross-coupling Cross-coupling reactions traditionally permit the formation of Ar‒Ar bonds between an aryl nucleophile and an aryl electrophile under transition metal catalysis. The high selectivity of the myriad of ...

chemrxiv.org/engage/chemr...

Ambiphilic cross-coupling.

🔥 An approach for light-driven, Ni-catalyzed C-heteroatom couplings that:

-Couples tough nucleophiles (yes, 3° alcohols!)
-Couples electron-rich aryl bromides
-Doesn't need a PC
-Runs on 100 ppm Ni
-Delivers on drug syntheses and late-stage modifications

Now on @chemrxiv.org: tinyurl.com/3ss6x24j

Josep Cornella & co-workers @cornellab.bsky.social unveil one-step heteroatom exchange🚀 A Ni(0)-catalyzed route converts #isoxazoles & #oxadiazoles into #pyrazoles & 1,2,4-triazoles🧪 A blueprint for rapid #azole scaffold exploration without de novo synthesis🌟
#nickel

👉 buff.ly/BabxqGG

🚨Calling medicinal chemists🚨:

A Suzuki het-het coupling sometimes does not require complex ligands. An air stable Ni would do. Amazing work from Rakan Saeb and Byeongdo Roh.
onlinelibrary.wiley.com/doi/10.1002/...

Deciphering the mechanism of oxidative addition of aryl iodides into a red-light active bismuthinidene. Incredible team: Alexios Stamoulis, Mauro Mato, Paolo Cleto-Bruzzese, M. Leutzsch, M. Gil-Sepulcre, A. Cadranel and F. Neese.
pubs.acs.org/doi/10.1021/...

Transmetalating a challenging tetrel: introducing aryl-[Si] synthons into bismuth organometallic catalysis. Great work spearheaded by Teresa and Sophia. onlinelibrary.wiley.com/doi/10.1002/...

The OMCOS-22 website has been updated. Registration and abstract submission are now open. Dr. Josep Cornella has been selected as the recipient of the OMCOS 22 Award. We congratulate Dr. Cornella and look forward to his award lecture in Kyoto. #OMCOS-22 omcos22.org

Scripps Research professor awarded the 2025 Nichols Medal by American Chemical Society - Scripps Research Magazine In recognition for developing activity-based protein profiling and advancing covalent drug discovery, Professor Benjamin Cravatt, PhD, the Norton B. Gilula Chair in Biology and Chemistry at Scripps Re...

Congratulations to Scripps Research Prof. Benjamin Cravatt, PhD, on receiving the 2025 William H. Nichols Medal from
@amerchemsociety.bsky.social for his pioneering work in activity-based protein profiling, advancing drug discovery for cancer & neurological disorders.

👋🏽 posting soon!