🔥 Late Breakers
SNAP platform RCT| Adjunctive Clindamycin in S.aureus bacteraemia
❌ No mortality benefit
90d mortality:16.9% vs 15.2% aOR 1.16 (CrI cross 1)
📊PPSup(~7%)→Futility threshold reached
⚠️ICU subgp:numerically worse with clinda
⚖️CDAD:no # (~2%)😯
#ESCMIDGlobal2026 #idsky
Late-breaking #Lancet SCOUT RCT results at #ESCMIDGlobal2026:
💊 Day 7 clinical resolution
• Nitrofurantoin: 74%
• Pivmecillinam: 70%
• Fosfomycin (2 doses): 67%
• Fosfomycin (single dose): 59%
🔑 single-dose fosfomycin underperforms vs standard short-course regimens
🔥 💥Late-Breakers |COBRA RCT
1-day of antibiotic treatment after adequate endoscopic biliary drainage is non-inferior to 4-7 days in adults with acute cholangitis.
💡 Shorter is better+source control
Practice-changing? #ESCMIDGlobal2026 #idsky
Of note this is second condition that in med school I learned needed anaerobic coverage.
Anaerobic coverage not needed in:
1) PNA after aspiration ❌
2) Sinusitis ❌
Highlights from late-breaking @TheLancet at #ESCMIDGlobal2026 📊
🔹 WGS + AI for RR-TB → better outcomes
🔹 UTI → nitrofurantoin best; fosfomycin worst
🔹 H5 immunity → partial cross-protection
🔹 M. pneumoniae CAP → steroids speed recovery
🚀 Precision + smarter antimicrobial use are shaping ID
@kottonnelson.bsky.social that’s my mentor!!
One-month treatment for latent tuberculosis.
Why aren't we using it? (Hint: We should.)
voices.nejm.org/doi/full/10....
ID fellow Alejandro De La Hoz Gomez, MD, of Mass General Brigham shares three things people don’t realize about a career in infectious diseases. #WhyILoveID
Say it louder for the people in the back
Very excited for this next (and last) stage of my training! We’re moving to New York!
Antagonistic interaction between posaconazole & olorofim in a murine model of invasive pulmonary aspergillosis
Posaconazole ⬇️ the effect of olorofim in vivo. Combination of olorofim+azole likely efficacious in wt infections, may be suboptimal in azole R infections
academic.oup.com/jac/article/...
Ah yes, the famously medium-spectrum doxycycline.
It only covers
Staphylococci
Pneumococci
Beta haemolytic Streptococci
Actinomyces
Mycoplasma
Chlamydophila
Legionella
H.influenzae
Moraxella catarrhalis
ESBL E.coli UTI
Pseudomonas UTI(maybe!)
Burkholderia pseudomallei
Vibrio
H.pylori
1/2
TLDR; We propose an optimized ASE 2.0 definition:
- allow POA infection diagnosis codes to anchor infection
- include pts discharged alive on QAD 3
- include hypotension w/out pressors (>/= 2 readings in 6h)
- include NIV or HFNC (>/= 2 days)
- minor changes in Plt, Cr, and Tbili thresholds
Good perspective from @simrangmd.bsky.social et al re use of PCT in ICU.
Particularly pertinent that as data and practice keep pointing towards shorter antibiotic course therapy, the window for diagnostic stewardship will narrow, limiting PCT benefit.
#IDSky #ClinMicro #AMR
Check out our viewpoint!
This is by far the most common vaccine I strongly recommend in ID adult clinical practice. As ID doctors, we see some truly severe cases of zoster, with post-zoster sequelae that may last months or even rarely be permanent. #IDSky doi.org/10.1093/cid/...
Procalcitonin-guided care cut antibiotic use by 1 day in sepsis patients but had no mortality impact. CRP showed no benefit. Adherence was low; future focus on early biomarker use is needed. 📉💊
#idsky
Herpes Zoster Vaccination and Dementia Occurrence
Herpes zoster vaccination eligibility reduced the probability of new dementia diagnoses, suggesting its potential preventive effect.
https://ja.ma/4lagSB6
🍾Last evening, the MGH & BWH ID faculty celebrated graduates of the MGB ID & MGH Transplant ID Fellowships, along with their families. It was a heartwarming celebration of stories, accolades, laughter, and tears. Special thanks go to our featured speakers Dr. Eric Rubin & Dr. Gabriel Motoa Cardona.🤩
Last few weeks with this BWH crew! @mgb-id-fellows.bsky.social
‼️Our new paper on social media in #TxID is officially out in @thetxidjournal.bsky.social
We summarize findings from our #TxIDChat @txidfellows.bsky.social
We discuss recs for trainees, career advancement, & future directions in this changing landscape. Check it out!
dx.doi.org/10.1111/tid....
This will kill so many people living with HIV who depend on PEPFAR programs to stay on their HIV treatment driving further HIV drug resistance.
www.nytimes.com/2025/01/24/u...
ICE was in my hospital today…
i am so beyond angry—this is unacceptable
stay away from our patients and let us do our jobs
CDC's Morbidity and Mortality Weekly Report (MMWR) has provided real-time data and analysis about disease outbreaks and emerging health threats without a break every week since 1960.
Until today.
Trump's Gag Order Halts CDC Publication www.medpagetoday.com/infectiousdi... For the first time in its more than 60-year history, the CDC's Morbidity and Mortality Weekly Report (MMWR) did not go out as scheduled.
Scientific advancements aside, this is economically irresponsible
Every $1 spent by NIH generates $2.46
For example, in 2023, $47B in NIH spending generated ~$93B
Halting NIH spending will LOSE the US a lot of money (and talent)
For those asking how unusual it is for NIH review panels to be cancelled: I do not recall study sections ever being cancelled during my 30-year career except for during the “sequestration” period around 2012-2013 when there was, I think, a government shutdown.
Oh. My.
Excited to share our research on duration of antifungal ppx for Cocci in SOT!
TLDR; For patients repeatedly pos for EIA-IgM-only w no seroconversion, compatible clinical illness, or rads findings, discontinuing antifungal ppx may be reasonable after 1st posttxp yr
journals.lww.com/transplantjo...
🆕💫Retrospective Cohort Study
Time to Staphylococcus aureus Blood Culture Positivity as a risk marker of IE
Short TTP was associated wit IE
NPV >95% suggests that TTP>13h can be used to risk stratify pts with SAB #idsky #EMIMCC
academic.oup.com/cid/article/...
academic.oup.com/cid/advance-...
