A closer look at the mechanism of microtubule nucleation💫. Thrilled to share our new work revealing CM1-activated gTURC. Great collaboration with Marina Serna, Claudia Brito, Jens Lüders and Thomas Surrey.
@cniostopcancer.bsky.social @crg.eu @irbbarcelona.org
www.nature.com/articles/s41...
One first decision after diagnosis was that I would continue: continue to work, continue to have fun, continue to laugh, continue to hope. Luckily I was always a person with a quite digital life. Using eye tracking you can still do a lot. Especially as a software developer.
Our paper is now out in Nature:
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.nature.com/articles/s41...
A short thread on how retrotransposons helped give rise to yeast point centromeres.
1/14
„[…] China, where the state’s involvement in science has historically been stronger than in the United States and most of Europe, is taking another approach: it is boosting funding for fundamental research.“
Don’t deprioritize curiosity-driven research www.nature.com/articles/d41...
Please share!
My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th!
uni-tuebingen.de/universitaet...
Impact of PDB Structures on Anti-Cancer Drug Approvals
Open access to PDB data facilitates discovery and development of life saving drugs. Learn more at PDB-101
#WorldCancerDay
#Addendum to 1970 paper, “CYTOPLASMIC FILAMENTS OF AMOEBA PROTEUS: I. The Role of Filaments in Consistency Changes and Movement,” includes eight video sequences originally recorded on 16-mm films. No technology was available at the time to include this data. 🎞️ rupress.org/jcb/article/...
#Actin
I wish you a great start at auf der Morgenstelle, Juan
No, thank you. With your article i learned about that paper in the first place!
Thank you for your article. It was an interesting read. There’s a small error, looks like nasty autocorr: R2Tg in STITCHR is found in zebra finch.
The Dana-Farber Cancer Institute’s multimillion-dollar settlement has been applauded by science integrity sleuths. https://scim.ag/4j3S65W
Congrats @deeganlab.bsky.social ! Officially forever young now
MT shape and orientation in what sense? Nucleators at MTOCs determine protofilament number and therefore impact MT shape. MT polarity as a consequence of nucleation, shapes and orients MTs as long as they remain anchored, wouldn‘t it?
Lovely!
Apparently Affinity was purchased by Canva only very recently. Canva appears not to be anti-subscription in general. So one way could be to start charging over time. Or as you say, for in-app purchases. Still, I am curious to what extent ‚basic‘ figure making can become free?
Been a fan since v1 so I’ll give v3 a try, too. I liked how easy it was to switch from adobe products. And so far I’ve never missed any feature. Any estimates how much academia funnels into adobe per year?
This is big news for academics, a fully* featured, modern vector editor software for free (hopefully) forever. We should be sad when research money is unnecessarily directed to the adobe whirlpool of subscriptions.
My final postdoctoral work will come out very soon, so watch this space 🧐.
In Amsterdam, I aim to decipher the molecular mechanisms of (cancer)-cell migration and adhesion using structural biology approaches. Positions available soon, so please reach out when you are interested! 😁
This one is a bit of a departure from the usual and definitely a work in progress!
We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.
Read on for details... 1/x
Frank Stahl, screen capture from: https://youtu.be/7-tnuAqEp9g
RIP Franklin W. Stahl (1929–2025)
here is Frank explaining semiconservative replication of DNA in the marvelous interview from 2020 together with Matt Meselson (youtu.be/7-tnuAqEp9g)
I’m excited to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @science.org ! (link at end of 🧵)
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social,
@marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social
🔗 Preprint here tinyurl.com/3a74uanv
Surely you have been using AlphaFold3 for your research project? If so, have you considered #AlphaBridge to analyze the output for macromolecule complexes prediction?
Web server: alpha-bridge.eu
Preprint: www.biorxiv.org/content/10.1...
New features coming soon!
We have an exciting opportunity for a new independent group leader with an interest in structural/molecular biology and machine learning to join our Division of Structural Studies at the @mrclmb.bsky.social! 🥳
Re-posts appreciated.
www.nature.com/naturecareer...
Bluetorial-A dream and a bit of a nightmare
Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.
7️⃣1️⃣ Jean Marian Purdy (1945-1985) 🇬🇧 #womeninSTEM Pioneer of fertility treatment. On 25/07/1978, the world learned of the birth of the 1st IVF baby: Louise Brown. Jean Purdy was part of the team that contributed to this success, but her name has been forgotten.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Very sad news today… Joan was director when I joined @IRBBarcelona.org and I owe him this great opportunity. He has led us to become not only a place for excellent science, but also a warm, friendly and collegial environment, a rare combination. We continue in Joan’s spirit, he will be missed!
