graphical abstract

Epigenetic changes at birth are intertwined with an infant's microbiome, and both contribute to neurodevelopment. spkl.io/63329A2jRx

Hein Min Tun, Francis Ka Leung Chan & colleagues
#CellPressBlue

Microbes as architects of colonic patterning

Highlight of @cp-cell.bsky.social paper discovering regionalization of colonic epithelium depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium.
www.cell.com/cell-host-mi...

Before immune system maturation, enteroendocrine cells regulate early-life gut function by controlling the microbiota through IL-22 @science.org
www.science.org/doi/10.1126/...

Intestinal epithelial cell MHC II is needed for induction of encephalitogenic CD4 T cells that migrate from gut to central nervous system @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

It’s well known that inflammation increases cancer risk, but how?

The answer: the epigenome "remembers" inflammation and primes stem cells for cancer.

Here is our paper: nature.com/articles/s41...
And a special shoutout to the lead author
@snaga13.bsky.social

A 🧵

The epigenome "remembers" inflammation and primes stem cells for cancer
@snaga13.bsky.social @nature.com @jbuenrostro.bsky.social @harvard.edu
www.nature.com/articles/s41...
www.nature.com/articles/d41...

LSMU seeks four Group Leaders in Kaunas-Kiel Microbiome & Precision Medicine Center to lead independent research groups with strong support.

4 Group Leaders/ PIs in Kaunas-Kiel Microbiome & Precision Medicine
Lithuanian University of Health Sciences

See the full job description on jobRxiv: https:

Engineering an in vivo charging station for CAR-redirected invariant NKT cells to enhance cancer therapy @natbiomedeng.nature.com
www.nature.com/articles/s41...

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma Yu et al. demonstrate that Staphylococcus is selectively enriched in metastatic lung tumor lesions. Staphylococcus nepalensis and S. capitis secrete lactate to promote the metastatic potential of tumo...

Weekend read:Tumor-resident Staph promotes metastasis

Staphylococcus enriched in metastatic lung tumor lesions. S. nepalensis & S. capitis secreted lactate promotes metastasis via MCT1-mediated pseudohypoxia signaling. MCT1 inhibition abolishes metastasis
www.cell.com/cell-host-mi...

In many #IBD patients, motility disorders persist even during remission. Kurapati et al. show that postinflammatory GI motility dysfunction arises from structural remodeling of the enteric nervous system, driven by a combination of neuronal loss & neurogenesis. rupress.org/jem/article/...

Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood. From LeBlanc, Sobel, @mikerobe.bsky.social and colleagues: rupress.org/jem/article/...

📘 In #Immunology Update Winter 2026 👉 rupress.org/jem/collecti...

Laser-based collection of bacteria from complex communities or tissue slices for in situ microbial single-cell omics
www.cell.com/cell-genomic...

Fungal commensal promotes intestinal repair via its secreted peptide in mice - Nature Microbiology A short peptide derived from a commensal-fungal-secreted protein promotes repair in models of colon epithelial damage when delivered directly or via probiotic microbes.

A fungal commensal secretes a protein that stimulates cellular regeneration in injured gut tissue in mice, with probiotic potential for treating gut-related conditions. #NBThighlight www.nature.com/articles/s41...

@biorxivpreprint.bsky.social Beyond the skin barrier: commensal S. epidermidis imprint systemic immunity to invasive biofilm infection
www.biorxiv.org/content/10.6...

In vivo detection of immune responses via cytokine activity labeling While much is known about the identity and regulation of cytokine-producing cells, the cell types that respond to cytokines remain largely uncharacter…

#CyclopsPower👁️ Lu, Choi, Huh &co describe @cp-cell.bsky.social a new reporter system to detect cells that respond to a cytokine & utilize it to identify ileal epithelial cells that respond to IL17 or IFNg responsive CD8 T cell within tumors which are hypofunctional!

γδ T cell receptor recognition of CD1d in a lipid-independent manner @natcomms.nature.com @monashuniversity.bsky.social
www.nature.com/articles/s41...

Excited to share research co-led by Gabby & Adam in @jem.org! Grateful to the NIH & @scripps.edu for support.

A bacterial toxin disarms gut defenses against inflammation Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice

New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org

Spatial fibroblast niches define #Crohn’s fistulae
@nature.com @ox.ac.uk
www.nature.com/articles/s41...

Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation @cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...

Allogeneic stem cell-engineered EGFRvIII-specific CAR-NKT cells for treating glioblastoma with enhanced efficacy and safety @moltherapy.bsky.social
www.cell.com/molecular-th...

New review 🔥 Single-cell RNA-Seq has been revolutionary for studying eukaryotic cells and now it's time for it to do the same for microbes! We describe the technology for single-bacterium RNA-Seq & the questions now studied using it.🧵⬇️
science.org/doi/10.1126/...
@andrewpountain.bsky.social

Commensal yeast promotes Salmonella Typhimurium virulence - Nature Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

#MycobiotaPower! Exciting work @nature.com by Behnsen, Jaswal &co showing that #Salmonella uses type 3 secretion system to hijack #Candida_albicans to produce arginine in the gut, boosting Salmonella infectivity & reducing the immune response! www.nature.com/articles/s41...

Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells @cp-med.bsky.social
www.cell.com/med/fulltext...

Fungal cues, fibrotic consequences: Commensal sensing by alveolar macrophages promotes pulmonary fibrosis In a recent issue of Immunity, Qiu et al. uncover a pivotal role for commensal fungi in promoting lung fibrosis, showing that their interaction with alveolar macrophages triggers a profibrotic transcr...

Fungal cues, fibrotic consequences:

Highlight of @cp-immunity.bsky.social work uncovering role for commensal fungi in lung fibrosis, showing that their interaction w/alveolar macrophages triggers profibrotic transcriptional program through Dectin-1-Raf1 signaling axis
www.cell.com/cell-host-mi...

This is so cool, congrats @lozanzi.bsky.social and team! Important implications for infection and IBD

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis @natimmunol.nature.com
www.nature.com/articles/s41...

📥 You have only until 24 June to submit your abstract for 'The human microbiome'❗

🔬💊 Explore cutting-edge breakthroughs in #microbiome research, from methodological innovations to integrative approaches and personalised therapeutics. Join #EESMicrobiome 🦠🔍

➡️ https://s.embl.org/ees25-08-bl