Synaptic dynamics as a tunable substrate shaping neuronal activity sequences www.biorxiv.org/content/10.64898/2026.03...

This identifies synaptic dynamics as a tunable substrate for shaping neural activity over time, with direct implications for how the brain learns precise sensory-motor relationships.

These sequences are not fixed. By tuning short term synaptic plasticity, cerebellar circuits can adjust the temporal structure of their representations across regions, matching the timescales of the behaviors they control.

Using in vivo two-photon imaging, synaptic physiology, glutamate imaging, and mathematical modelling, we show that synaptic dynamics at cerebellar mossy fiber-to-granule cell synapses transform continuous sensory-motor input into temporally sparse neural sequences.

Have you ever wondered how the brain represents and uses information that unfolds over time?

One powerful strategy is to organize activity into neural sequences, brief bursts of activity that tile behavior. But what determines the structure of these sequences?

I am excited to share a new study on cerebellar granule cell neural sequences from our lab (www.biorxiv.org/content/10.6...). This study is the result of years of work by an exceptional team of postdocs and students.

@adamhantman.bsky.social

🧩 This discovery overturns the long-held assumption that inhibitory neurons act as simple relays, showing instead that their dendrites perform specialized computations that sculpt the timing and flow of cortical activity. 🧠🔬

Today we’re celebrating Selin Schamiloglu (DiGregorio Lab) for receiving an NINDS F32 Grant for: “A cerebellar synaptic mechanism for temporally precise behaviors.”
A huge achievement—congrats, Selin! 🧠🎉

🧠📢 June publications are in!

We’re thrilled to share “Cerebellar circuit computations for predictive motor control” from our very own Person Lab, authored by Abby Person and Katrina P. Nguyen! 📝✨

👉 Click the link in our bio to dive into this exciting research!

Structural basis of fast N-type inactivation in Kv channels - Nature This paper explores how voltage-gated potassium channels can plug the pore to prevent the conductance of ions during inactivation.

The Department of Physiology and Biophysics continues to be a leader in excellence 💪 Congratulations to our wonderful faculty member, Dr. Ana Fernandez-Mariño, on her publication: “Structural basis of fast N-type inactivation in Kv channels.” 📖 #NewPub

🔗 nature.com/articles/s41586-025-09339-7

Rewire Your Brain: Electrical Vagus Nerve Stimulation for Motor and Cognitive Healing | Welle Lab YouTube video by Physiology and Biophysics CU Anschutz

Meet Dr. Cristin Welle, a professor of Physiology & Biophysics, and Neurosurgery at CU Anschutz.

Her lab is leading research at the intersection of technology and the brain, bringing us closer to understanding our nervous systems function.

🎥 Learn more: youtu.be/XKpzR6Fu3Qo

It was a pleasure to host you here in Denver!

Such bad news.