https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1471192/full

https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1471192/full

📌

www.frontiersin.org/journals/cel...

The impact of COVID-19 on accelerating of immunosenescence and brain aging

Ludmila Müller
Svetlana Di Benedetto

Max Planck Berlin 🧪

Dezember 2024

⚠️ immunosenescence ⚠️

Längliches Bilf mit Bäumen im Hintergrund. Darauf folgender Text: Wenn man versteht, dass ein Wald im Kapitalismus erst dann einen „Wert" hat, wenn er abgeholzt wird, beginnt man, die Wurzel unserer ökologischen Krisen zu begreifen.

Wenn man versteht,
dass ein Wald im Kapitalismus erst dann einen „Wert" hat,
wenn er abgeholzt wird, beginnt man, die Wurzel unserer ökologischen Krisen zu begreifen.

Für Freunde des Popcorns: 🍿

Berliner Forschungsgruppe: Corona schleicht sich über Immunzellen in L Ein Forschungsteam unter Leitung der Charité hat herausgefunden, dass Lungenschäden bei Covid-19 auf eine durch Makrophagen ausgelöste Immunaktivierung zurückzuführen sind.

Hocke: „Unsere Studie deutet darauf hin, dass schwere Lungenschäden bei Covid-19 eher auf eine durch Makrophagen ausgelöste Immunaktivierung als auf eine direkte Zerstörung der Lungenbläschen durch das Virus zurückzuführen sind."

www.universimed.com/de/berliner-...

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilises the angiotensin-converting enzyme 2 (ACE2) transmembrane peptidase as cellular entry receptor. However, whether SARS-CoV-2 in the alveolar compartment is strictly ACE2-dependent and to what extent virus-induced tissue damage and/or direct immune activation determines early pathogenesis is still elusive.MethodsSpectral microscopy, single-cell/-nucleus RNA sequencing or ACE2 “gain-of-function” experiments were applied to infected human lung explants and adult stem cell derived human lung organoids to correlate ACE2 and related host factors with SARS-CoV-2 tropism, propagation, virulence and immune activation compared to SARS-CoV, influenza and Middle East respiratory syndrome coronavirus (MERS-CoV). Coronavirus disease 2019 (COVID-19) autopsy material was used to validate ex vivo results.ResultsWe provide evidence that alveolar ACE2 expression must be considered scarce, thereby limiting SARS-CoV-2 propagation and virus-induced tissue damage in the human alveolus. Instead, ex vivo infected human lungs and COVID-19 autopsy samples showed that alveolar macrophages were frequently positive for SARS-CoV-2. Single-cell/-nucleus transcriptomics further revealed nonproductive virus uptake and a related inflammatory and anti-viral activation, especially in “inflammatory alveolar macrophages”, comparable to those induced by SARS-CoV and MERS-CoV, but different from NL63 or influenza virus infection.ConclusionsCollectively, our findings indicate that severe lung injury in COVID-19 probably results from a macrophage-triggered immune activation rather than direct viral damage of the alveolar compartment.

publications.ersnet.org/content/erj/...

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilises the angiotensin-converting enzyme 2 (ACE2) transmembrane peptidase as cellular entry receptor. However, whether SARS-CoV-2 in the alveolar compartment is strictly ACE2-dependent and to what extent virus-induced tissue damage and/or direct immune activation determines early pathogenesis is still elusive.MethodsSpectral microscopy, single-cell/-nucleus RNA sequencing or ACE2 “gain-of-function” experiments were applied to infected human lung explants and adult stem cell derived human lung organoids to correlate ACE2 and related host factors with SARS-CoV-2 tropism, propagation, virulence and immune activation compared to SARS-CoV, influenza and Middle East respiratory syndrome coronavirus (MERS-CoV). Coronavirus disease 2019 (COVID-19) autopsy material was used to validate ex vivo results.ResultsWe provide evidence that alveolar ACE2 expression must be considered scarce, thereby limiting SARS-CoV-2 propagation and virus-induced tissue damage in the human alveolus. Instead, ex vivo infected human lungs and COVID-19 autopsy samples showed that alveolar macrophages were frequently positive for SARS-CoV-2. Single-cell/-nucleus transcriptomics further revealed nonproductive virus uptake and a related inflammatory and anti-viral activation, especially in “inflammatory alveolar macrophages”, comparable to those induced by SARS-CoV and MERS-CoV, but different from NL63 or influenza virus infection.ConclusionsCollectively, our findings indicate that severe lung injury in COVID-19 probably results from a macrophage-triggered immune activation rather than direct viral damage of the alveolar compartment.

2️⃣0️⃣2️⃣2️⃣🧪

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

Katja Hönzke Benedikt Obermayer Christin Mache et al.

European Respiratory Journal 2022 60(6): 2102725;

DOI: doi.org/10.1183/1399...

Nuvaxovid™ COVID-19 Vaccine Showed Better Tolerability than mNEXSPIKE in Head-to-head Sanofi-led Phase 4 Study Novavax is a biotech company with a proven technology, focused on developing our R&D assets and establishing partnerships to help protect health.

👋

ir.novavax.com/press-releas...

Great Question, Winona.......

SF Department of Public Health confirms first clade I mpox case The San Francisco Department of Public Health on Tuesday confirmed the first case of clade 1 mpox in a city resident.

Clade 1 MPOX confirmed in San Francisco www.ktvu.com/news/sf-depa...

military-medicine.com/das-post-cov...

Beim Aufrufen des Links dauert's ein bißchen, lohnt sich aber 👇

#Post-COVID-Syndrom in der ⚕️ Bundeswehr: Ein Jahr Post-COVID-Studie am Bundeswehrzentralkrankenhaus ­Koblenz – Zwischenauswertung und Einordnung der ­wehrmedizinischen Relevanz
👇

Hospitalization rates for illnesses like COVID, flu have doubled since pre-pandemic, report finds | CBC News Striking new data from the Canadian Institute for Health Information (CIHI) shows hospitalization rates for vaccine-preventable respiratory diseases more than doubled in 2024, compared to pre-pandemic...

Are they being hospitalized with or from these illnesses? Are we sure it's not just immunity debt? Maybe it smart phones causing it? Have they thought about brunching through it? 🙃😵‍💫 There's obviously nothing we can do to stop airborne diseases & really should we? 🙃

www.cbc.ca/news/health/...

A BlueSky thread by 🤜❤️‍🔥🤛 Challenger 🧪 Sourcecontrol.bsky.social. 🦋 on Skyview 1/7: Die Illusion der

skyview.social?url=https://

Einstufung der Landesregierung in Baden-Württemberg als "verfassungsfeindliche Vereinigung" und Beobachtung durch den Verfassungsschutz sofort !

Anna Schneider ist der Wolf im 🐑 's Pelz #Bitch

Hast Du gut entschieden 👍

Five years of the COVID-19 pandemic: An interview with Dr. Arijit Chakravarty In this interview, Dr. Chakravarty discusses the current state of the COVID-19 pandemic and public health globally five years after the initial outbreak of the SARS-CoV-2 virus in Wuhan, China.

Public Health was saying, “Masks are the scarlet letter of the pandemic,” in the words of former CDC Director Rochelle Walensky. Or “If you have been vaccinated, the pandemic is over for you,” www.wsws.org/en/articles/...

#RememberCorrectly
"It has long been known that Covid can damage brain metabolism, even in mild cases. Hardly anyone in Germany wants to hear this. The prevailing attitude is 'dead or recovered.'

But when it comes to children, we should be fair and avoid every unnecessary infection"

2️⃣0️⃣2️⃣1️⃣👇

https://x.com/Karl_Lauterbach/status/1458580067848802313?t=W-qhVrH6Q0eo5CruRLK6DA&s=19

#RichtigErinnern

Dass Covid den Gehirnstoffwechsel beschädigen kann, auch bei leichteren Verläufen, ist lange bekannt. Das will in Deutschland kaum jemand hören. Konzept ist „tot oder genesen“. Aber bei Kindern sollten wir so fair sein, jede unnötige Infektion zu vermeiden

Karl Lauterbach wurde am 8. Dezember 2021 als Bundesminister für Gesundheit im Kabinett Scholz vereidigt, der tweet stammt vom 11.11.2021.

Danach hat er Durchseuchung der Kinder mitgetragen 🤬

https://x.com/Karl_Lauterbach/status/1458580067848802313?t=W-qhVrH6Q0eo5CruRLK6DA&s=19

#RichtigErinnern

Dass Covid den Gehirnstoffwechsel beschädigen kann, auch bei leichteren Verläufen, ist lange bekannt. Das will in Deutschland kaum jemand hören. Konzept ist „tot oder genesen“. Aber bei Kindern sollten wir so fair sein, jede unnötige Infektion zu vermeiden

Neuroinvasion of SARS-CoV-2 in human and mouse brain Neurological symptoms are frequently observed in COVID-19. Here, we examine the neuroinvasive potential of SARS-CoV-2 and demonstrate infection of neurons

Friendly reminder

12.01.2️⃣0️⃣2️⃣1️⃣

in autopsies from patients who died of #COVID-19, we detect #SARSCoV2 in cortical neurons and note pathological features associated with infection with minimal immune cell infiltrates.🧠
👇
rupress.org/jem/article/...

J Exp Med (2021) 218 (3): e20202135. https://doi.org/10.1084/jem.20202135

These results provide evidence for the neuroinvasive capacity of SARS-CoV-2 and an unexpected consequence of direct infection of neurons by SARS-CoV-2.

😷

T cell apoptosis characterizes severe Covid-19 disease - Cell Death & Differentiation Cell Death & Differentiation - T cell apoptosis characterizes severe Covid-19 disease

Friendly reminder

SARSCoV2 infections are characterized by lymphopenia, but the mechanisms involved are still elusive.

There was this publication
22 January 2022

👇
T cell apoptosis characterizes severe Covid-19 disease

www.nature.com/articles/s41...

As part of my efforts to combat the COVID Amnesia Project, let's accurately remember what 3 influential laptop class doctors from Stanford said 6 years ago as COVID overflowed hospitals and morgues.

They won't remind you.

I will.

My latest.

Connemann ist untragbar

Die beschwören uns, statt zu kapieren, dass permanente Durchseuchung mit SARS-C💀V-2 der Wirtschaft schadet.

Die Krankschreibungen europaweit werden nun angeprangert, nachdem man Covid-19 und andauernde Infektionen als 'corona Schnupfen' (🤡) normalisierte⚠️

🤢🤮

#CovidIsNotOver
#CovidIsAirborne

Von wann ist der Video Ausschnitt?

Zur Person: Mohammed Amin al-Husseini – Wikipedia share.google/LJIvUbDpbd5W...

6/6
Whether it’s "Directed Evolution" or the "Lab Leak," the pattern is the same: Information is managed, critics are silenced, and transparency is sacrificed for control. The feeling of being "gaslit" isn't a theory—it’s a response to shifting facts. 🚫🤐

@skyview.social unroll