A microphysiological model of human MASLD reveals paradoxical response to resmetirom - Communications Biology Hyperinsulinemia, glucose and fatty acids induce hepatic triglyceride accumulation, proinflammatory cytokine release and predispose to insulin resistance, while resmetirom treatment normalized fat but...

A month late - but wrapped up my postdoc with a publication in Comms Bio 🎉

www.nature.com/articles/s42...

Quantitative 3D imaging of mouse and human intrahepatic bile ducts in homeostasis and liver injury Intrahepatic bile ducts (IHBDs) form a complex hierarchical network essential for liver function. Remodeling and expansion of this network during ductular reaction (DR) is a hallmark of liver disease ...

Preprint out now (@graczlab.bsky.social): doi.org/10.1101/2025...
We establish a 3D imaging (iDISCO/light sheet microscopy) + analysis pipeline to quantify intrahepatic bile duct (IHBD) architecture during homeostasis and liver injury — in both mice and humans. 🧵 1/8

Multi-zonal liver organoids from human pluripotent stem cells - Nature Liver organoids derived from human induced pluripotent stem cells populations grown with ascorbate and bilirubin can be used to recapitulate differential zonal functions of human hepatocytes and for transplantation in animal models of liver dysfunction.

Nature research paper: Multi-zonal liver organoids from human pluripotent stem cells

https://go.nature.com/3G7Pepk

Systems biology framework for rational design of operational conditions for in vitro / in vivo translation of microphysiological systems www.biorxiv.org/content/10.1101/2025.01....

graphical abstract

Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below)
www.medrxiv.org/content/10.1...

Graduate Reductions Across Biomedical Sciences (2025)

We are crowd sourcing reductions in graduate admissions and hiring freezes across biomedical research and higher ed in response to pauses in NIH funding and EO’s. If you have information if you could add to this spreadsheet, it would be greatly appreciated!: docs.google.com/spreadsheets...

Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis Nature Communications - The bile ducts of the liver form a network of large ducts and small ductules, though how they are patterned remains unclear. Hrncir et al. show that Sox9 is required for the...

Some good news: @hannahhrncir.bsky.social ‘s primary PhD paper is finally online! This study lays the groundwork for a lot of technical and conceptual things the lab is currently working on, including light sheet microscopy for imaging entire biliary trees in mouse liver: rdcu.be/d90Br 1/4

Congrats @graczlab.bsky.social and @hannahhrncir.bsky.social 🎉🎉🎉

A Microphysiological Model of Progressive Human Hepatic Insulin Resistance www.biorxiv.org/content/10.1101/2025.01....