Kupffer cell plasticity regulates hepatic immunity in mycobacterial infection Kupffer cells (KCs), the prenatally seeded macrophages of the liver, show unique functional and immunophenotypic features among tissue-resident macrophages. They are considered as terminally different...

New in @JHepatology: An excellent paper from our fantastic Jana Neuber’s PhD project. Novel insights into macrophage plasticity in mycobacterial infection. Read it here:
www.journal-of-hepatology.eu/article/S016...

EFIS-ELINE - Seminars Seminars run on the first Thursday of every month at 16:00 CET. We kick off with a 15-minute spotlight talk from an early-career researcher, then a senior scientist takes the stage for a deeper dive, ...

We are excited to kick-off of our seminar series on March 5, 4pm CET 🥳

🎤 Petter Brodin – A seeding reaction to colonizing microbes in human newborns
🎤 Eva Stange – Neonatal liver niches program T cell tolerance

Register here: www.efis-eline.eu/seminars

#EarlyLifeImmunity #Immunology #EFIS

Freshly in press from the Henneke lab: LDL cholesterol is required for macrophages to form multinucleated giant cells after BCG exposure. Congrats to Dr. Philipp Merck for an impressive MD thesis! And congrats to the team, so proud to have been part of this.
www.nature.com/articles/s41...

Online now: Sensory neurons shape local macrophage identity via TGF-β signaling

Frontiers | Immunopathogenic and clinical implications of advanced tissue analysis in non-tuberculous mycobacterial infections in children ObjectivesInfections with non-tuberculous mycobacteria (NTM) in children usually affect the lymph nodes and surrounding tissue. Although the infection is typ...

Excited to share our new paper on pediatric non-tuberculous mycobacterial (NTM) lymphadenitis. Using advanced histology we identify patterns associated with favorable outcomes. We hope this helps refine NTM care.
Open access @Frontiers in Immunology:
www.frontiersin.org/journals/imm...

Recovery from Pediatric Inflammatory Multisystem Syndrome Temporally-Associated with SARS-CoV-2: Follow-Up from a Nationwide German Cohort To investigate the intermediate-term health impacts of pediatric inflammatory multisystem syndrome temporally-associated with SARS-CoV-2 (PIMS-TS).Usi…

Follow-up study: After our recent paper on PIMS-TS/MIS-C across pandemic waves, we’re now reporting on intermediate-term outcomes. Read the paper @Journal of Pediatrics:

www.sciencedirect.com/science/arti...

Mycobacterial infection uncovers plasticity of Kupffer cells www.biorxiv.org/content/10.1101/2025.02....

Sensory neurons shape macrophage identity via TGF-β signalling www.biorxiv.org/content/10.1101/2025.02....

Tissue imprinting defines functional mosaic of dermal macrophages Dermal macrophages (macs) protect the skin from invading pathogens. They are derived from embryonic as well as hematopoietic progenitors. However, the functional impact of their diverse origin and the...

Excited to announce a new preprint from the Henneke Lab:

"Tissue imprinting defines functional mosaic of dermal macrophages"

It explores how dermal macrophages adapt and specialize within their microenvironment during infections. Feedback and discussions welcome!

www.biorxiv.org/content/10.1...

Join the cutting-edge discussions at the International Symposium on Perinatal and Early Life Immunity, April 9-12 2025, Freiburg, Germany.
www.perinatal-immunity.de/en/symposium2025
Late-breaking abstracts still accepted!

In press @Journal of Pediatrics

Clinical insights from the German PIMS-TS cohort: A comprehensive analysis of an all-but-extinct pediatric inflammatory disease.

www.jpeds.com/article/S002...