The Cavro syringe pumps out of old TECAN robots are solid, talk over serial, and are usually under $100 on ebay

Clear sparkley gem held between thumb and forefinger over green background

Portuguese pavilion + step crown in natural quartz

Lifted from Forrest Gump.

A blue faceted gem viewed top down, showing many facets in a scale-like pattern

120 facets on the crown in blue glass

Optical posts arranged in an orderly array in a toolbox drawer

Under the right conditions optics posts will crystalize

Logo of Bin Chicken (Australian white ibis) on a rubbish bin, pulling out a strand of DNA

“Bin Chicken” is now published in Nature Methods! It substantially improves genome recovery through rational coassembly 🧬🖥️. Applied to public 🌍 metagenomes, we recovered 24,000 novel species 🦠, including 6 new phyla.
doi.org/10.1038/s415...
@benjwoodcroft.bsky.social @rhysnewell.bsky.social
🧵1/6

Bin Chicken: targeted metagenomic coassembly for the efficient recovery of novel genomes - Nature Methods By developing a strategy of metagenomic coassembly and prioritizing divergent marker gene sequences, Bin Chicken efficiently recovers more than 77,000 microbial genomes with high novel diversity, ther...

www.nature.com/articles/s41...

This is it. This is the best cheeky pun name for a research method.

Perfection.

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

www.nature.com/articles/s41...

Universal consensus 3D segmentation of cells from 2D segmented stacks - Nature Methods u-Segment3D is a universal framework that translates and enhances 2D instance segmentations to a 3D consensus instance segmentation without training data. It performs well across diverse datasets, inc...

A game changer in our hands... www.nature.com/articles/s41...

If the first one wasn't a Catholic wedding the church doesn't think it counts.

Ringo Star and George Carlin, the tiny railway conductors.

A blue faceted gem is glued to the end of a metal shaft. The gem is lit brightly against a dim background of wood table and grey wall

Sun hit just right

A rectangular gem stone with purple and red sparkles

Pixel cut on glass. Dialing in machine alignment.

Bright green polished and faceted glass. It's cut in a pattern with 13 sides.

Frosted green glass faceted in a radially symmetric pattern with 13 sides.

13-mer on the new faceting machine

Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth Early in the evolution of life a biochemical network was encapsulated within a membrane compartment. This study shows that specific membrane forms can select for stereochemical compounds which match t...

ICYMI, from Tom Richards, Stefano Pagliara et al, on how extant homochirality might have arisen

"we demonstrate that both membranes select for d-ribose and d-deoxyribose sugars while the hybrid membrane uniquely selects for a reduced alphabet of l-amino acids."

journals.plos.org/plosbiology/...

Syringe pumps out of a Tecan liquid handler are like $100 on eBay and take RS232 commands. Add an Arduino for USB.

Finished another cross bar cut blue topaz

"Your idea is so far from reality I'm not sure how to start testing it."

Like someone asserting that the universe must be deterministic on all length scales because apparently we have souls and souls can influence stochastic atomic decay events in our brains.

Comic. The Most-Observed Animal and Plant in Each State on iNaturalist. (Not the most common species in the state, just the one people have reported the most times.) [labeled map of the US] WA: Mallard/Western Sword Fern. OR: Mule Deer/Western Ponderosa Pine. CA: Western Fence Lizard/California Poppy. HI: Green Sea Turtle/‘Ōhi’a Lehua. ID: Mallard/Big Sagebrush. NV: Common Side-Blotched Lizard/Creosote Bush. MT: White-Tailed Deer/Common Yarrow. WY: American Bison/Sticky Geranium. UT: Mule Deer/Utah Juniper. AZ: Ornate Tree Lizard/Saguaro. CO: Mule Deer/Great Mullein. NM: Mule Deer/Creosote Bush. AK: Moose/Fireweed. ND: American Bison/Prairie Rose. SD: American Bison/Hoary Vervain. NE: American Robin/Common Milkweed. KS: Ornate Box Turtle/Amur Honeysuckle. OK: Pond Slider/Eastern Redcedar. TX: Northern Cardinal/Pinladies. MN, WI, IL: Common Eastern Bumble Bee/Common Milkweed. IA, MI: White-Tailed Deer/Common Milkweed. MO: Brown-Belted Bumble Bee/Amur Honeysuckle. AR: Three-toed Box Turtle/Chinese Privet. LA: Green Anole/Baldcypress. IN: American Robin/Amur Honeysuckle. OH: Eastern Pondhawk/Virginia Springbeauty. KY: Common Box Turtle/Amur Honeysuckle. TN: American Robin/Christmas Fern. MS: Northern Cardinal/Pale Pitcher Plant. AL: Gulf Fritillary/American Sweetgum. GA: Green Anole/American Sweetgum. FL: Brown Anole/White Beggarticks. NY: Eastern Gray Squirrel/White Snakeroot. PA: White-Tailed Deer/Garlic Mustard. WV: White-Tailed Deer/Great Rhododendron. VA: White-Tailed Deer/Eastern Poison Ivy. MD: White-Tailed Deer/Wineberry. DE: Fowler’s Toad/American Pokeweed. NC: Eastern Gray Squirrel/Christmas Fern. SC: Northern Cardinal/American Sweetgum. NJ: Spotted Lanternfly/Common Mugwort. VT: Common Eastern Bumble Bee/Eastern White Pine. NH: White-Tailed Deer/Eastern White Pine. MA: Common Eastern Bumble Bee/Eastern White Pine. CT: Common Eastern Bumble Bee/Striped Wintergreen. RI: American Herring Gull. ME: American Herring Gull/Canadian Bunchberry.

iNaturalist Animals and Plants

xkcd.com/3118/

The lens tube versions are rarely centered to under a mm but at least there you can blame the slop on thread clearance

Dude wanted to be Sec of State soooo bad

Nevermind real and it's a yeast thing

Schmoo?

Cant leave out the part about the bear you were running from. Or towards.

Just out: we used SReD to measure the periodicity of spectrin rings along axons, finely capturing the effect of actin depolymerization. This and many more applications ➡️ www.nature.com/articles/s41...

Another great collab with @henriqueslab.bsky.social, congrats @afonsomendes92.bsky.social et al 🙏

Very nice!

Nothing quite has the same feeling as the first time you can see light out the far end.

Yes it needs the corresponding Zeiss tube lens. Part no 423731-8246-000.

We are excited to share our development of a new 10X lens with NA=0.50 over a 7.2 mm FOV and a 35 mm working distance (water), fully corrected from 400-850 nm. This lens will power our upcoming ExA-SPIM "2" and is available for dissemination - please get in touch if interested!

Sparkley green gemstone in a triangular cut

Triforce cut in synthetic topaz

Opposing bar cut in sky blue synthetic topaz