We are really happy for the support from @kawresearch.bsky.social and for this nice piece about our research!

We are grateful for funding by @vetenskapsradet.bsky.social @erc.europa.eu @kawresearch.bsky.social Kempestiftelserna and Jeanssons stilftelse

This work was led by our talented postdoc Bolor Buyanbadrakh with the help of others in our lab, and the labs of Madeleine Ramstedt, Björn Schröder (@mucubacter.bsky.social) and Sun Nyunt Wai.

Our mechanistic follow-up unveiled that guanine could boost the pH increasing effect of V. parvula.
Amazingly, this worked even in three-member communities of a pH lowering strain, a strain sensitive to low pH and V. parvula to rescue the growth.

Then we turned our focus to the overall trend of most phyla to grow worse in spent media that has low pH.
An exception to this was Veillonella parvula, which can cope well with low pH. We observed that V. parvula can increase spent media pH and allow low pH-sensitive Bacteroidota species to grow.

We followed up on one of the rare positive interactions, and observed that Clostridium perfringens promotes the growth of Mediterraneibacter gnavus through extracellular vesicles.

We used a spent medium approach to profile the growth interactions, and as previously observed in different ecosystems, we observed mostly negative interactions. These reflect species occupying the same metabolic niche and competing for nutrients, or altering the environment (e.g., lowering pH).

Systematic profiling of growth interactions in human gut microbiome species Microbial interactions shape the composition and stability of the human gut microbiome. Yet, the molecular mechanisms underlying these relationships remain poorly understood. Here, we systematically p...

New preprint from the lab is out! 🥳

We systematically profiled all pairwise growth interactions between 36 representative human gut microbiome strains, and delved deeper into the molecular mechanisms behind specific growth interactions.

www.biorxiv.org/content/10.6...

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Really cool story from @lisamaierlab.bsky.social!
We are happy that @luuuprz.bsky.social (PhD student in our lab) contributed a small part.

Annika Druy joined our lab as a PhD student! Annika will study mechanisms of drug resistance in species of the human gut microbiome. She is part of the ENDAMR doctoral network (endamr.eu).

We welcome Didrik, who will help us study the biosynthesis of O-glycans in Bacteroidota species.

What a fantastic week of science! And it couldn’t have finished in a better way, with Lucia winning one of the best poster awards! #EESMicrobiology

Looking forward to this conference! Elisabeth and Lucia are presenting posters. Visit them at posters 56 and 212. #EESMicrobiology

FEBS Press Species of the Bacteroidota phylum exhibit a unique O-glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species-specific outer g....

As we start exploring this unique system of O-glycosylation in Bacteroidota species, we have reviewed the current state-of-the-art and offer some ideas on the directions we want to take. #glycotime doi.org/10.1002/2211...

Looking forward to this conference! A few of us from the lab will be there.

We welcome Lieke for her bachelor thesis during the spring. She will help us study a specific O-glycosylation system of Bacteroidota species.

Check more details about the ENDAMR doctoral network here: endamr.eu

In this project the candidate will look at drug resistance mechanisms in microbiome species.

PhD position in Chemistry, with a specialization in biochemistry The Department of Chemistry is opening a PhD position in Chemistry with a specialization in biochemistry. The thesis project will focus on drug resistance mechanisms in microbiome species, and is part

We have a PhD student position open in the context of the ENDAMR doctoral network. Deadline is 31/May. Apply here: umu.varbi.com/en/what:job/...

We are excited to be part of this network! We will open a PhD position soon, so keep an eye open.

We are really excited for the opportunity to collaborate with @typaslab.bsky.social @dbikard.bsky.social and the Strowig lab.

Victor Pinedo has joined our lab as a postdoc! Victor will study Archaeal species of the human gut microbiome.

Our first post since the migration to bluesky! Follow our group for news on our efforts to map protein function on species the human gut microbiome.