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Posts by Joe Zackular

Bhattacharya killing one of the most promising technologies in a generation for improving health, treating disease, & preventing mass death from pandemics was unforgivable; this will be his legacy

I was interviewed about his lies about mRNA vaccines here: www.bioxconomy.com/modalities/e...

1 day ago 75 26 2 0

I'm not joking when I say mRNA technology is more important than "AI" and it's a tragedy we're throwing billions into one while our government is aggressively defunding the other.

2 days ago 14917 5516 114 106

Such a fantastic visit! Thank you to @vanessasperandio2.bsky.social for hosting me! Had a blast connecting with the AMAZING @uwmadisonmmi.bsky.social community!!

3 days ago 2 0 1 0
Seminar announcement flyer for the Medical Microbiology & Immunology Seminar Series at the University of Wisconsin. The flyer reads: "12:05 PM | 1520 Microbial Sciences Building." Featured event: April 17 — talk titled "Clostridioides difficile Pathogenesis: from Nursery to Nursing Home" by Dr. Joseph Zackular, University of Pennsylvania. A photo shows Dr. Zackular, a smiling man in a light blue shirt, standing in a laboratory setting. The UW Department of Medical Microbiology and Immunology logo appears in the bottom left. Sponsored by the UW Department of Medical Microbiology & Immunology, School of Medicine and Public Health, and the Bonnie DeMeio Fund.

Seminar announcement flyer for the Medical Microbiology & Immunology Seminar Series at the University of Wisconsin. The flyer reads: "12:05 PM | 1520 Microbial Sciences Building." Featured event: April 17 — talk titled "Clostridioides difficile Pathogenesis: from Nursery to Nursing Home" by Dr. Joseph Zackular, University of Pennsylvania. A photo shows Dr. Zackular, a smiling man in a light blue shirt, standing in a laboratory setting. The UW Department of Medical Microbiology and Immunology logo appears in the bottom left. Sponsored by the UW Department of Medical Microbiology & Immunology, School of Medicine and Public Health, and the Bonnie DeMeio Fund.

At the top of the hour... Come see today's exciting @uwmadisonmmi.bsky.social seminar by @joeyzacks.bsky.social!

3 days ago 10 1 2 0
2,599 applicants offered NSF GRFP awards!

Congrats to all the NSF GRFP award winners and recipients of honorable mention.

https://www.research.gov/grfp/AwardeeList.do?method=loadAwardeeList

2,599 applicants offered NSF GRFP awards! Congrats to all the NSF GRFP award winners and recipients of honorable mention. https://www.research.gov/grfp/AwardeeList.do?method=loadAwardeeList

Massive and important positive news...

#NSF #GRFP awards are out.

2,599 awards!
+
1,440 Honorable Mentions.

A significant boost from last year.

Congratulations to the winners (and HM-s)!

& many thanks to the reviewers & program officers who made this possible.

www.research.gov/grfp/Awardee...

1 week ago 175 54 0 2

Tomorrow is the last day to submit an abstract for @keystonesymposia.bsky.social meeting Beyond Antibiotics: Emerging Strategies Combating Bacterial Infections.

It is going to be an amazing meeting and we have a few slots left!
keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

1 week ago 5 6 1 0
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Enhancing Diabetic Wound Healing: A little help from Alcaligenes faecalis? #Microbiome #ActAgainstAmputation diabeticfootonline.c...

1 week ago 5 3 0 0
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UW graduate student deported through SEA as protesters demand answers A union representing University of Washington graduate student workers says Kennedy Orwa’s student visa was rescinded without explanation.

Our PhD student Kennedy Orwa, who studies applications of AI to health care, was hastily deported today to Kenya along with his 13-year-old son without opportunity to speak to legal counsel.

King 5 reports that he held a valid visa that was rescinded without explanation.

1 week ago 4159 2282 87 113
Research Scientist Click the link provided to see the complete job description.

My lab at Pitt is looking for a Research Scientist to help us make phage therapy for patients with antibiotic-resistant infections. Please share and apply! cfopitt.taleo.net/careersectio...

1 week ago 69 75 0 1
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Orlaith Keenan in the Zackular lab (@joeyzacks.bsky.social) defends her thesis tomorrow!

1 week ago 3 2 0 0
Excerpt from article interview of Paul Offit where he describes an interaction from 2005nwuth RFK Jr. 

"He made me a bad guy" Offit told The Philadelphi a Citizen last fall. "But I honestly don't think anybody is going to kill me. I certainly don't think they'll give me a heads-up first. They just want me to shut up." "And," he added, “fuck them."

Excerpt from article interview of Paul Offit where he describes an interaction from 2005nwuth RFK Jr. "He made me a bad guy" Offit told The Philadelphi a Citizen last fall. "But I honestly don't think anybody is going to kill me. I certainly don't think they'll give me a heads-up first. They just want me to shut up." "And," he added, “fuck them."

@pauloffit.bsky.social is a total badass

2 weeks ago 114 27 4 2
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Paul Offit vs. RFK Jr. Is the Battle of Our Times How Philly's leading vaccine doctor became MAHA's public enemy number one

www.phillymag.com/news/2026/04...

2 weeks ago 41 13 0 2
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Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!

Only TWO WEEKS left to register for @keystoneSymposia.bsky.social Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection, in Breckenridge!

Check out the lineup of speakers - it is going to be an amazing meeting! Join us in May! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

3 weeks ago 2 3 0 1
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Pharmacological reduction of neutrophil infiltration reduces Clostridioides difficile infection severity | mBio Clostridioides difficile remains a leading cause of antibiotic-associated diarrhea worldwide and a major healthcare burden. While antibiotics are commonly used to treat CDI, high antibiotic resistance...

Happy to share this study from the lab led by Orlaith Keenan published in mBio!

Working with an outstanding collaborative team, Orlaith demonstrated that maintaining the right balance of neutrophils is key to limiting severe disease during C. difficile infection. journals.asm.org/doi/10.1128/...

3 weeks ago 6 4 0 0
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Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection | Keystone Symposia Join us at the Keystone Symposia on Beyond Antibiotics: Emerging Strategies for Combating Bacterial Infection, May 2026, in Breckenridge, with field leaders!

Only TWO WEEKS left to register for @keystoneSymposia.bsky.social Beyond #Antibiotics: Emerging Strategies Combating #BacterialInfection, in Breckenridge!

Check out the lineup of speakers - it is going to be an amazing meeting! Join us in May! keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

3 weeks ago 2 3 0 1
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The genetics of obesity: aetiology, prevention and therapy - Nature Metabolism This Review discusses the genetics of obesity, highlighting its diverse forms and describing technological advancements in genetic studies that may enable precision medicine strategies to combat obesi...

Delighted to contribute to this review of the genetics of obesity, just out in @natmetabolism.nature.com, led by Amélie Bonnefond and Philippe Froguel.

@chopresearch.bsky.social @penngenetics.bsky.social

www.nature.com/articles/s42...

4 weeks ago 16 8 0 0
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Very provocative new paper in @natmicrobiol.nature.com

As global temps rise, drought is becoming more frequent and prolonged across many regions

Paper shows climate-driven drying of soils can fuel antimicrobial resistance at its ecological source, independent of clinical antibiotic use

🧵 (1 of 6)

3 weeks ago 24 14 2 0

Does an imbalanced gut microbiome worsen chronic kidney disease?

By elucidating the ecological causes for changes in the gut microbiota composition during chronic kidney disease and its consequences for disease progression we were able to answer this question.

4 weeks ago 14 5 1 0

I endorse this message

1 month ago 2 0 0 0
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Bile acid dependent attenuation of toxin mediated disease is independent of colonization resistance against C. difficile www.biorxiv.org/content/10.6...

1 month ago 1 2 0 0
Image from their link showing evidence of fabricated references

Image from their link showing evidence of fabricated references

Holy smoke. What ultimately happened???

1 month ago 213 77 9 21

Call me when they start fighting over whether naming the lab after the PI is abusive to trainees

1 month ago 2 0 1 0

Even among healthy people, immune systems operate at different baseline levels.

In our new Cell paper, we show that these immune states are stable over time and are associated with the gut microbiome. 🧵
@cp-cell.bsky.social
#Immunology #SystemsImmunology

1 month ago 28 13 2 0
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@biorxivpreprint.bsky.social Acute Paternal Immune Activation Shapes Embryonic Development and Protects Offspring from Viral Infection
www.biorxiv.org/content/10.6... @upenn.edu
@cambupenn.bsky.social @colinconine.bsky.social @kelliejurado.bsky.social

1 month ago 8 1 1 0
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RFK Jr. wants Dunkin’ to prove drinking its iced coffee is safe - The Boston Globe The warning comes as Kennedy is leaning heavily into his agenda to improve American diets.

This moron has no idea how much of a third rail this is. If he goes through with a public fight with Dunkin he will never live this down. In the words of my people "fuck ya motha."

1 month ago 10586 1677 1020 675
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Fred Hutchinson Cancer Center Fred Hutch is dedicated to the elimination of cancer and related diseases as causes of human suffering and death.

My awesome colleague, @yarimura.bsky.social, is recruiting a postdoc to start at the end of 2026 or early 2027! His lab uses cryo-EM to uncover structural basis of key chromatin events using native complexes isolated from human cells or Xenopus egg extracts!

careers-fhcrc.icims.com/jobs/30706/p...

1 month ago 32 21 1 0
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Penn Vet Scientists Earn National Honors for Breakthrough Research in Virology and Cancer Innovation Penn Vet's Louise Moncla, PhD, receives Ann Palmenberg Junior Investigator Award; Timour Baslan, PhD, named 2026 Damon Runyon–Rachleff Innovation Award recipient

www.vet.upenn.edu/penn-vet-sci...

1 month ago 8 2 0 0
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Poster of the 2026 CSHA meeting on Bacterial Infection & Host Defense.

Poster of the 2026 CSHA meeting on Bacterial Infection & Host Defense.

Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!

1 month ago 27 25 1 0
KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics)
KSQA: Drs. Joseph P. Zackular & Mariana X. Byndloss (Beyond Antibiotics) YouTube video by KeystoneSymposia

⏰ Last chance to save $250! Register for Beyond Antibiotics by 11:59pm MST on March 5.

Join @joeyzacks.bsky.social, @kimingeneva.bsky.social, @dariavantyne.bsky.social & @maribyndloss.bsky.social to spark new collaborations.

🎥 youtu.be/8Ppjx-MnvxA
keysym.us/KSBeyondAnti...

#KSBeyondAntibiotics26

1 month ago 4 5 1 1
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Metabolic modeling reveals determinants of prebiotic and probiotic treatment efficacy across multiple human intervention trials Prebiotic and probiotic interventions can induce therapeutically relevant shifts in the human microbiome, but their effects are variable across individuals. This study shows that metabolic models can ...

Latest from @gibbological.bsky.social.

"We [use] microbial community-scale metabolic models to predict probiotic engraftment and microbiota-mediated short-chain fatty acid (SCFA) production in response to probiotic and prebiotic interventions...w/75-80% accuracy."

journals.plos.org/plosbiology/...

1 month ago 14 6 1 0