Another captivating @sinclaircri.bsky.social seminar coming up! Dr. Jim Petrik from @uofguelph.bsky.social, hosted by @drpostovit.bsky.social, will be presenting here in #YGK on April 7th at 4 PM. Everyone is welcome to join! @queensuhealth.bsky.social @queensuresearch.bsky.social #cancerresearch

check out our newest preprint showing that #dedifferentiation in certain types of #endometrialcancers may be due to transcriptional chaos rather than cellular reprogramming

Cell State Chaos Underpins the Evolution of SMARCA4-Deficient Dedifferentiated Endometrial Cancer Dedifferentiated endometrial carcinoma (DDEC) is a histologically unique cancer type, wherein well-differentiated regions lie adjacent to morphologically distinct, high-grade lesions that are histolog...

www.biorxiv.org/content/10.6...

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.

☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
@kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social
bit.ly/47IXjvX

Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.

Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome www.nature.com/articles/s41...