Inflammatory cytokine upd3 induces axon length–dependent synapse removal by glia | PNAS Many neurodegenerative disorders (NDDs) preferentially affect neurons with long or complex axonal arbors but the cellular and molecular bases for n...

Check out our newest work together with the Parrish lab showing the intrinsic vulnerability of neurons with long axons for synapse loss by glial phagocytosis. www.pnas.org/doi/10.1073/...

Peptidergic top-down control of metabolic state-dependent behavioral decisions in a conflicting sensory context Animals make economically beneficial behavioral decisions by integrating the external sensory environment with their internal state. The metabolic state, i.e. hunger, can shift priorities, prompting r...

First post on Bluesky! We show how the metabolic state affects preference behavior in Drosophila larvae in a conflicting sensory context. Turns out neuromodulatory peptides are the key, exerting context-specific top-down control on an avoidance circuit.
www.biorxiv.org/content/10.1...