Excited to share our preprint led by Ain Chung
& @jasonalipio.bsky.social showing how immature adult-born DGCs preferentially recruit inhibition of CA2 and CA3 to disproportionately affect hippocampal network properties and social memory. We began by asking 1/n
www.biorxiv.org/content/10.1...

Graphical abstract from the paper depicting the overall study design

Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published.

www.cell.com/cell-reports...

Re-upping this PAID summer internship opportunity!

The Bond Lab believes you have to #StandUpforScience because science is for everyone

MARK YOUR CALENDAR for #BrainAwarenessWeek at Mount Sinai! For 13 years the #FriedmanBrainInstitute has joined the @danafoundation.bsky.social in its global efforts to increase public awareness of the progress & benefits of brain research. JOIN US during March for some incredible #BRAIN events!

Epigenetic signatures of intergenerational exposure to violence in three generations of Syrian refugees - Scientific Reports Maternal trauma influences infant and adult health outcomes and may impact future generations through epigenetic modifications such as DNA methylation (DNAm). Research in humans on the intergenerational epigenetic transmission of trauma effects is limited. In this study, we assessed DNAm signatures of war-related violence by comparing germline, prenatal, and direct exposures to violence across three generations of Syrian refugees. We compared families in which a pregnant grandmother versus a pregnant mother was exposed to violence and included a control group with no exposure to war. We collected buccal swab samples and survey data from mothers and 1–2 children in each of 48 families (n = 131 participants). Based on an epigenome-wide association study (EWAS), we identified differentially methylated regions (DMPs): 14 were associated with germline and 21 with direct exposure to violence. Most DMPs showed the same directionality in DNAm change across germline, prenatal, and direct exposures, suggesting a common epigenetic response to violence. Additionally, we identified epigenetic age acceleration in association with prenatal exposure to violence in children, highlighting the critical period of in utero development. This is the first report of an intergenerational epigenetic signature of violence, which has important implications for understanding the inheritance of trauma.

A study in Scientific Reports supports the theory of the intergenerational epigenetic transmission of violence trauma in humans by identifying novel DNA methylation sites and evidence for epigenetic age acceleration. These results indicate important directions for future research. 🧪

Judge issues preliminary injunction blocking Trump cuts to NIH research overhead payments A federal judge issued a nationwide preliminary injunction blocking the Trump administration from slashing NIH payments for research overhead

Preliminary injunction in nationwide indirect cost rate case.

This means that the judge found that the plaintiffs (AAMC, et al.) are likely to win on the merits when the ruling is finalized.

www.statnews.com/2025/03/05/n...

Overhead Costs

⚕️ What are the 'overhead' costs that the NIH wants to cut? ✂️

Improved and simplified explainer.

As usual, feel free to reuse and remix as needed (as long as it's for educational purposes). This is released under a Creative Commons BY-NC license.

#NIHcuts #overheadcosts #academicsky

The Department of Cell and Developmental Biology, Feinberg School of Medicine seeks a full-time tenure track Investigator at the rank of Assistant Professor. Click here to learn more.
www.feinberg.northwestern.edu/sites/cdb/do...
For questions, contact
Vanessa Gonzalez vanessa.g@northwestern.edu

Twitter, Instagram, Blue Sky and LinkedIn: Summer Undergraduate Research Fellowships (S.U.R.F.) are invaluable opportunities for undergraduates to gain research experience, career development and mentorship! Join Black in Neuro on Friday, January 10, 2025 at 12 PM ET for an information session with universities on the SURF application process. Register below here: https://tinyurl.com/4mzjyz9 Alt text: Flyer is on a transparent background of a laboratory. At the top right is the Black In Neuro logo. Text at the top aligned in the middle says, A Session on SURF. Under this text says, Interested in a Summer Undergraduate Research Fellowship (S.U.R.F.)? Join us for an info session with programs to learn application tips and more. On the bottom in the middle is a rounded rectangle of icons with calendar, clock, and location symbols on the left side. To the right is a blue bubble that says, January 10 2025. Under this is a blue bubble that says, 12:00-1:30 PM ET. Lastly is a blue bubble under that says Zoom. Black text on a yellow rectangle reads “ What is SURF?” Black text on lab experimental backgrounds reads, “Summer Undergraduate Research Fellowship (SURF) are 8-10 week research programs for students. SURF programs are great for people who want to pursue careers in STEM (science, technology, engineering, and mathematics)! Black text on smaller individual yellow rectangles also read “ SURF provides: Career Development, Financial Support, Research Experience, Mentorship, and Networking”. Black In Neuro logo in top left.

Black text on a yellow rectangle reads “ What is SURF?” Black text on lab experimental backgrounds reads, “Summer Undergraduate Research Fellowship (SURF) are 8-10 week research programs for students. SURF programs are great for people who want to pursue careers in STEM (science, technology, engineering, and mathematics)! Black text on smaller individual yellow rectangles also read “ SURF provides: Career Development, Financial Support, Research Experience, Mentorship, and Networking”. Black In Neuro logo in top left.

Summer Undergraduate Research Fellowships (SURF) are invaluable opportunities for undergraduates to gain research experience, career development and mentorship! Join us Friday, Jan 10 at noon ET for an information session with universities on the application process.
Register 👉🏽 tinyurl.com/4mzjyz9 🧪

🎨+🎥+🔬+🧠= The "Art of the Brain"! The Call for Images is NOW OPEN! All #FriedmanBrainInstitute depts & individuals are encouraged to submit high quality, visually compelling works of art that relate to the brain. Deadline 🖌️ 1/13/25 at 5pm. Submit Here 👉 tinyurl.com/z7j95ft8

Delighted to announce a new call for applications for our Pathway to Independence programme. Now entering its third year, this scheme supports postdocs going on the job market in 2025 - with training, mentorship, profile-raising and networking opportunities. Application deadline 31 Jan 2025. 1/3