CytoTape in a neuron

Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...

A scientific plot, showing how the binding affinity of a magnetically-controlled nanobody changes when a magnetic field is applied. A 40 millitesla field reduces the nanobody's binding affinity by about threefold.

Here's binding curves, with and without a ~40 mT magnetic field.

We estimate a handheld magnet changes the binding affinity by ~3x.

This is the world's first (real) demonstration of "magnetogenetics" - controlling protein function with nontoxic, tissue-penetrating magnetic fields.

Great news! @mariaingaramo.bsky.social 's company (Nonfiction Labs) made a remote-controlled antibody.

Its binding turns on and off with a magnet.

This is a HUGE step towards our dream of magnetically controlled drugs. Imagine a cancer drug that ONLY attacks the tumor, not the rest of your body.

‘Remote controlled’ proteins illuminate living cells The discovery that some fluorescent proteins are sensitive to magnets could lead to the development of switchable drugs and biosensors.

Researchers have engineered magnetically controlled fluorescent proteins that can be remotely dimmed and brightened in cells and living animals

go.nature.com/3NUSY12

A new interesting opening at our Microscopy Core Facility. There is still time to apply!

Our snouty v3 (AMS-AGY v3) objective arrived today! Looking forward to getting it installed on our single objective light sheet system very soon...

Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028

🚨 Job Alert! 🚨

We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇

abo.rekrytointi.com/paikat/index...

#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social

I’m very happy that our paper is now published in Angewandte Chemie! 👏 A Photoswitchable HaloTag for Spatiotemporal Control of Fluorescence in Living Cells.
↪️ onlinelibrary.wiley.com/doi/full/10....
Big thanks again to all co-authors (especially Bego) and collaborators for their contributions! 👏

Excited to share the second chapter of my PhD work - Photoclickable HaloTag Ligands for Spatiotemporal Multiplexed Protein Labeling on Living Cells! 🥳 A big thank you to @clairedeo.bsky.social and all co-authors who contributed to this work.
➡️ www.biorxiv.org/content/10.1...

Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...

(1/x) Excited to report VIPS (Volumetric imaging of biological specimens via photochemical sectioning) @science.org! VIPS uses light-based sample sectioning to eliminate the inherent imaging depth limit of high-resolution optical microscopes @supgokul.bsky.social: www.science.org/doi/10.1126/...

Halfway to I2K is BACK, friends of all kinds! Last year, 650 people attended 30+ TOTALLY FREE image analysis workshops of all kinds, across many timezones.

If you make image analysis software and want to teach it, workshop submissions are open now! We'd love to have your tool highlighted.

I'd like to share a little bit of happy lab news in these chaotic times: a new preprint, driven by the brilliant Qinhao Cao!
www.biorxiv.org/content/10.1...
We address a big challenge in synbio: If you give me a protein "X", how can I give you a version of X whose activity is controlled by a kinase?

Our manuscript on accelerating the acquisition rate in oblique plane microscopy (OPM) is online now:

opg.optica.org/boe/fulltext...

Our work addresses the issue that an OPM PSF is tilted, and as such it leaves a lot of "empty space" in Fourier space (FFT of experimental data on the right)... 1/n

Teach your #microscope how to print: Low-cost & rapid-iteration #OpenSource #microfabrication for #biology:

-µm-scale precision across cm-sized area
-no cleanroom requirement
-SU8 replacement

Preprint: doi.org/10.1101/2025...
#DIYbio #lab #instuments #imaging #microfluidics #fabrication #3Dprinted

Mechanism of giant magnetic field effect in fluorescence of mScarlet3, a red fluorescent protein Several fluorescent proteins, when expressed in E. coli, are sensitive to weak magnetic fields1. We found that mScarlet3 fluorescence in E. coli reversibly decreased by 21% in the presence of a 60 mT ...

New in biorxiv on magnetogenetic design -
"key reaction step involved e- transfer ...to form a triplet spin-correlated radical pair. The magnetic field then controlled the branching ratio between singlet recombination vs. triplet separation."
www.biorxiv.org/content/10.1...

I recommend these optomechanics for 'O2-O3' in a single-objective light-sheet (SOLS) microscope:
-> Mechanically and thermally stable.
-> Relatively straightforward to align.
-> 10 popular configurations.

Make your own:

github.com/amsikking/SO...

Or buy it from @jsdaniel02.bsky.social at ASI!

Do you LOVE organelles??
Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social!

Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy

🧵1/N

👋

I am excited to announce that the Journal of Cell Science will have a special issue on imaging cell architecture and dynamics, guest-edited by myself and Lucy Collinson. Consider this issue to publish your work.
Find out more: journals.biologists.com/jcs/pages/im...

New program out for IDPseminars!

New attendees sign up here: idpseminars.com

We have relied heavily on Twitter for our PR until now, so its slow but painful death spiral leaves us in a bit of a pickle. Please help us rebuild our following over here by re-tweeting.

Biologists ask me all the time:
How can we gain computational skills?

Here are some thoughts! Quotes from Shantanu Singh, Virginie Uhlmann, Fernanda Garcia Fossa, and @bethcimini.bsky.social

www.nature.com/articles/d41...