I am a fan of fish but just end up using the zsh on my mac

Re:science, an issue is that ppl don't have a great grasp of stats. Even those w/quant bkgds.

Populations & systems aren't the same as a person. If you have X% risk, you don't get only X% of the outcome.

Also, diff in risk is not always a meaningful diff. A person is not a system to be optimized!

Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬

But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock
1/2

Offering a free bowl of gummy bears is the best value-for-money to make your guests/co-workers feel pampered

Book Review: Eric Turkheimer's "Understanding the Nature-Nurture Debate" Or, some thoughts on The Gloomy Prospect and the Gloomy Present

I wrote about Eric Turkheimer's recent book on "the nature-nurture debate", which should be of interest to people thinking not just about the genetics of behavior but complex traits more broadly. A 🧵:

I couldn't spot a starter pack for rare disease / clinical genomics, so I started one: go.bsky.app/SUWZ9Hw

Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged.

#ClinicalInformatics #genomics #bioinformatics 🖥️🧬

+1 for bookmarks until then this is the only one I could find and at 7.5 bucks per month (not really convinced by their value proposition) getdewey.co/bluesky/

Picture of six people smiling in the snow in the city of Denver

A picture of Yuyang Chen giving a presentation. In the background a large screen has a slide saying "Variants in RNU4-2 cause a neurodevelopmental disorder (ReNU syndrome)". In the foreground, many people sit listening to the talk.

A poster is being presented while others listen.

Back home and reflecting on a fantastic week at #ASHG24.
It was wonderful to reconnect with friends, make new connections, and be surrounded by amazing science! 🧬

This was my first time attending ASHG with many of my amazing team (see below). They did an incredible job representing the group 🥰 1/2

THE SIMPSONS PARADOX

A starter pack of starter packs 😛 Love it!

The original paper that laid out the purification theorem was John C. Harsanyi's 1967-1968 work titled "Games with Incomplete Information Played by ‘Bayesian’ Players," which was published in a three-part series in Management Science. These papers developed the foundation of Harsanyi's approach to games with incomplete information, including the purification theorem. Here are the references for the original papers: Harsanyi, J. C. (1967). Games with Incomplete Information Played by ‘Bayesian’ Players, Part I. The Basic Model. Management Science, 14(3), 159-182. Harsanyi, J. C. (1968). Games with Incomplete Information Played by ‘Bayesian’ Players, Part II. Bayesian Equilibrium Points. Management Science, 14(5), 320-334. Harsanyi, J. C. (1968). Games with Incomplete Information Played by ‘Bayesian’ Players, Part III. The Basic Probability Distribution of the Game. Management Science, 14(7), 486-502.

Your periodic reminder that ChatGPT is not a research tool.

(The purification theorem was presented in Harsanyi's 1973 Int J Game Theory paper, not in the famous Management Science trilogy.)

US startup charging couples to ‘screen embryos for IQ’ Heliospect’s services were marketed at up to $50,000 for 100 embryos, undercover footage shows

Hope not Hate as well as the Guardian doing an amazing job of exposing crap science and the con men behind it.

www.theguardian.com/science/2024...

‘Race science’ group say they accessed sensitive UK health data Exclusive: Fringe network recorded boasting of securing data from UK Biobank trove donated by 500,000 volunteers

Wow, the Guardian journalists who just yesterday published about the network of race scientists getting funding from tech CEOs just broke another story that this group has accessed UK Biobank data without authorization. This is seriously bad for the integrity of science & a massive failure by UKBB

Setuptools are your best bet

setuptools.pypa.io/en/latest/us...

What are we learning from the genes of siblings? Family-based genetic analyses come of age

I wrote a bit about the two very interesting studies of siblings/families from last week. Tan et al. family GWAS (medrxiv.org/content/10.1...) and Sidorenko et al. sibling heritability estimates (nature.com/articles/s41...).

I love that tortitude

Cats were never domesticated so much as they live symbiotically next to us lesser mortals 😂

Meanwhile. Elsewhere and Elsewhen...

Protein wrangler, serial entrepreneur, and community builder: Inside David Baker’s brain Institute for Protein Design leader believes success lies in building a team and research community interconnected like a nerve center

Chem Nobel for protein structure prediction and de novo design! While she writes up the news, please enjoy @laurahowes.bsky.social 's deep dive into David Baker's brain:

cen.acs.org/biological-c...

Geoff Hinton is a greatly respected AI pioneer but surely they find a physicist to receive the most respected prize in physics.

Enough AI hype.

Expect the next Nobel Prize in Physics to be a biologist because biology is applied chemistry and chemistry is applied physics.

Will be looking forward to it!

Why Marital Status is Heritable I often feel as though I am swimming upstream when I make the case that behavioral genetics is not headed for a golden future in which the genetics of intelligence and schizophrenia are understood all...

Reminds me of this wonderful substack a while back

ericturkheimer.substack.com/p/why-marita...

Applied Statistics

Them killing it would be admitting that they did wrong. That ain’t the Apple way

The DNA Nexus project system is like an S3 system from what I can see. You can push major updates using dx upload from local git branch and then run things there.

But for interactive analysis like Jupyter or Rstudio doesn’t seem like it is as easy

This is something that I severely miss whilst working in the RAP.

Git integration is essential and I hear that a solution is in the works. Don’t exactly know what it looks like. Or when.

The only alternative I am using so far is creating apps rn.

I am guessing you then run the code by copy pasting it from GitHub to R/Jupyter?🫣