Congrats!

The cholinergic system exerts opposing effects on memory at different stages of disease progression in Alzheimer's and Down syndrome model systems INTRODUCTION The long-standing cholinergic hypothesis posits that cholinergic signaling is uniformly deficient in Alzheimer's disease (AD) and Down syndrome (DS). We tested the hypothesis that this ...

For decades, Alzheimer’s therapies assumed more acetylcholine = better memory. Our new paper in @alzdemjournals.bsky.social challenges this dogma, showing that the cholinergic system has opposite effects on memory depending on disease stage.

📌 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

More than 20 years after their discovery, HFOs are reshaping how we understand epilepsy and increasingly, revealing important links to other brain disorders. In our new paper we reflect on how far the field has come and where it’s headed next.
#HFOnews
onlinelibrary.wiley.com/doi/10.1002/...

Thank you @cureepilepsy.bsky.social for this honor and for supporting my lab’s work on high frequency oscillations in epilepsy through a CURE Epilepsy award! #HFOnews
Congratulations to all awardees!

Not just one biomarker, but many! Join our Epilepsy and Aging SIG for an exciting multimodal biomarker session. The session has it all from basic science to neuropsychology, EEG, and more!

🗓️ Monday, December 7, 2:00-3:30pm, Room GWCC B312, Level 3. @amepilepsysoc.bsky.social @yes-ilae.bsky.social

The @amepilepsysoc.bsky.social AES Annual Meeting is quickly approaching - have you marked your calendar for the exciting EEG BIOMARKER CHALLENGE? We will tackle whether EEG biomarkers are disease specific and WHY that matters!

🗓️ Sunday, December 7, 4:00-5:30pm

Join us! #HFOnews

Not to be missed!! Mark your calendar! Great networking opportunity.

This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect of levetiracetam on the oscillations’, by Shandilya et al. @chrislisgaras.bsky.social
Read at 👉 buff.ly/r3IcOEE

Opposing interictal dynamics in Alzheimer’s disease and epilepsy Advanced EEG technology has revealed that epileptiform activity occurs more frequently in Alzheimer’s disease (AD) than previously recognized, prompti…

New paper out! We show that EEG biomarkers interact in opposite ways in Alzheimer’s disease (AD) vs. epilepsy. This could explain why epileptiform activity is inconsistently seen in AD—and highlights the need for wideband EEG to uncover these dynamics. #HFOnews

www.sciencedirect.com/science/arti...

High frequency opportunities for Alzheimer’s disease This scientific commentary refers to ‘High-frequency oscillations in epileptic and non-epileptic Alzheimer's disease patients and the differential effect o

Greatly enjoyed writing this piece for @braincomms.bsky.social!

🔹 "High frequency opportunities for Alzheimer's disease" academic.oup.com/braincomms/a...

This commentary calls for rethinking how we “listen to” and interpret abnormal electrical activity in Alzheimer’s disease and related dementias.

Congratulations Liset!

Off to beautiful Lisbon to speak the XVIII Workshop on Neurobiology of Epilepsies. Excited about this year’s topic on the resilient brain! Who’s coming?! #HFOnews 🧠 #ILAE @ilae-epilepsy.bsky.social

High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia INTRODUCTION Alzheimer's disease (AD) dementia has near full penetrance in adults with Down syndrome (DS) and is strongly linked to late-onset myoclonic epilepsy in Down syndrome (LOMEDS). However, ...

Exited to share our new work! We found scalp high frequency oscillations (HFOs) in adults with Down syndrome, before the clinical onset of Alzheimer’s dementia and late onset myoclonic epilepsy.
HFOs may hold the key to earlier diagnosis #HFOnews
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Impact of Alzheimer's disease on sleep in adults with Down syndrome INTRODUCTION Down syndrome (DS) is a genetic form of Alzheimer's disease (AD), with a high prevalence of sleep disorders, but data in adults with DS and dementia are lacking. We aim to assess sleep ...

Interested in how sleep is affected across the Alzheimer’s disease continuum in people with Down syndrome? 💤
Check our new publication with collaborators in Spain out in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Congratulations Martha!!

Likewise! Chat soon 🍻

Attending too!

Interested in how preclinical studies can help understand EEG patterns? Take a look at our book chapter! With Marco de Curtis and Premysl Jiruska.
link.springer.com/chapter/10.1...
#HFOnews

#HFOnews! And first outcome publication of the Third International Workshop on High Frequency Oscillations in Epilepsy. 👇👇

Scientific Program If  you determine at the last minute that you cannot travel to Verona, you will have the option of providing a video of your presentation, which will be played in the session in which you are...

Off to beautiful Verona for the Spring Hippocampal Research Conference! Who’s coming?! #HFOnews

hippo.euroconferences.org/scientific-p...

Excited to be speaking about High Frequency Oscillations in Epilepsy and Sleep at the 2nd Annual Sleep Conference in NYC!

Happy World Down Syndrome day! We are advocating and are all inspired by individuals with Down syndrome. #WDSD2025

Join us next week for an @ilae-epilepsy.bsky.social webinar on High Frequency Oscillations! Dr. Sheybani @laurentsheybani.bsky.social and Dr. Jacobs will talk all about HFOs in epilepsy. #HFOnews

Register here: docs.google.com/forms/d/1e-x...

A great one by @laurentsheybani.bsky.social - on the reading list!

Great! hello to the team!!

Beyond amyloid: Targeting a broader range of Alzheimer's disease factors Learn how Alzheimer's and dementia research targets have evolved.

www.nia.nih.gov/research/blo...

#HFOnews

Our #EEG Review was selected as @epilepsiajournal.bsky.social Editor’s Featured Article - give it a read here👇

onlinelibrary.wiley.com/doi/10.1111/...

High‐frequency oscillations (250–500 Hz) in animal models of Alzheimer's disease and two animal models of epilepsy Objective To test the hypothesis that high-frequency oscillations (HFOs) between 250 and 500 Hz occur in mouse models of Alzheimer's disease (AD) and thus are not unique to epilepsy. Methods Exper.....

Super excited to see our 2022 animal model study (onlinelibrary.wiley.com/doi/10.1111/...) showing HFOs in Alzheimer’s model systems replicated in humans! @braincomms.bsky.social
The dream of every basic scientist 🤩

Our human study coming very soon :)

#HFOnews

academic.oup.com/braincomms/a...

Our review discussing the role of EEG in Epilepsy research is now out @epilepsiajournal.bsky.social @ilae-epilepsy.bsky.social

Thanks to all of my co-authors!

onlinelibrary.wiley.com/doi/10.1111/...