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Posts by Stephen V Mahler

Officially out today! Long-running project, many thanks to give - in particular to my mentors & collaborators, the postbacs who worked so hard on each experiment, and the reviewers. If you love the amygdala, give it a read.
www.sciencedirect.com/science/arti...

4 days ago 48 19 6 2

Join me online today at 1pm ET to hear how the @zuckermanbrain.bsky.social Public Programs team built our Teacher Institute for Neuroscience and Society program for NYC middle school teachers: cnlm.uci.edu/connect

Thank you to @danafoundation.bsky.social for making this program possible!

🧪🧠

5 days ago 9 3 1 0

It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants…reviewers, program officials and funders can be more empathetic in the face of unprecedented chaos in the US scientific enterprise.

1 week ago 174 45 5 5

Happy to report mine and Kent’s paper exploring cortical hedonic hotspots is officially out! 🐀🐀🐀

2 weeks ago 9 1 0 0
NOT-OD-26-064: Update of NIH Late Application Submission Policy and End of Continuous Submission NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Update of NIH Late Application Submission Policy and End of Continuous Submission NOT-OD-26-064. NIH

Notification of the end of continuous submission and updating the late submission policy.

grants.nih.gov/grants/guide...

2 weeks ago 9 12 4 3
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a baby is crying in a crowd of people while a woman holds it . ALT: a baby is crying in a crowd of people while a woman holds it .

Some totally awesome updates from grant-witness.us

All of my funding curves and more in an easily useful form!

grant-witness.us/funding_curv...

🧵

1/7

3 weeks ago 67 25 3 2
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Mechanistic insights into the therapeutic properties of delta opioid receptor Integrated structural and dynamic analyses uncover strategies to target the δ-opioid receptor for improved analgesic efficacy.

Mechanistic insights into the therapeutic properties of delta opioid receptor | Science Advances www.science.org/doi/10.1126/...

3 weeks ago 5 4 0 1

Yes! We literally cannot shut up about our work.

1 month ago 56 16 3 0
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UC Irvine Center for Addiction Neuroscience (ICAN) Symposium - Charlie Dunlop School of Biological Sciences Bridging the Lab and the Clinic to Address Addiction and Comorbid Affective and Psychosis Disorders Please register below for the UC Irvine Center for Addiction Neuroscience (ICAN) Symposium on Wednes...

Interested in addiction and cormorbid disorders?
Join us for our ICAN symposium on Mar. 18 in @ucirvine.bsky.social, featuring Josh Gordon, @neurovoice.bsky.social, Tony George, @nanopharmnc.bsky.social, Khaled Moussawi, Meg Fox, Firoza Mamdani, & more! All welcome!
www.bio.uci.edu/event/ican-s...

1 month ago 3 2 0 1
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White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

www.nature.com/articles/d41...

1 month ago 10 9 0 1
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The Journal of Neuroscience: 46 (8)

Very excited to share a Special Collection at the Journal of Neuroscience (@sfnjournals.bsky.social) - Central Questions for Social Neuroscience Research. This issue includes some of the latest perspectives on social neuroscience research. Please check it out!👇

www.jneurosci.org/content/46/8

1 month ago 27 16 0 0
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Dopamine Supports Reward Prediction to Shape Reward-Pursuit Strategy Reward predictions not only promote reward pursuit, they also shape how reward is pursed. Such predictions are supported by environmental cues that signal reward availability and probability. Such cue...

🚨📃New Wassum Lab Paper 📃🚨

Out today, Melissa Malvaez, Nick Griffin, Andrea Suarez & team discovered that dopamine can enable reward predictions to shape how we pursue reward.

Surprisingly, we find that dopamine can constrain instrumental reward seeking.

www.jneurosci.org/content/46/8...

🧵👇🏻

1 month ago 62 25 5 0
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A simple voluntary action reduces high-fat diet intake and obesity in mice

This is a very elegant multi-continental study 👏

www.cell.com/current-biol...

2 months ago 7 2 0 0

I am so proud to share @forrestdrogers.bsky.social’s postdoctoral magnum opus, now out in @nature.com! Forrest discovered a novel role for Agouti in the MPOA of the hypothalamus to integrate socio-environmental information to flexibly tune paternal behavior
www.nature.com/articles/s41...
Thread! 👇🏻

2 months ago 143 39 18 5

New Special Issue out in #AddictionNeuroscience edited by @talialerner.bsky.social on dopamine circuitry and heterogeneity in addiction with articles by @daylab.bsky.social, Tom Hnasko, @mtorregrossa1.bsky.social, and Awatramani Rajeshwar check it out! www.sciencedirect.com/special-issu...

2 months ago 13 8 0 0
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EBPS2023 special issue: Stress, trauma and cannabinoids - Psychopharmacology Psychopharmacology -

Excited to share the Psychopharm Special Issue on Stress, Trauma & Cannabinoids 14 papers examining how the endocannabinoid system shapes stress & trauma responses.

Guest edited with @connorhaggarty.bsky.social, @mayoonthebrain.bsky.social & Christelle Baunez.

link.springer.com/article/10.1...

2 months ago 8 6 0 0

ugh. ugh. ugh.

2 months ago 12 6 2 1

👉👃

2 months ago 1 1 0 0
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Neuroscience has a species problem

The problem is not simply that cross-species translation is difficult; it is that the field has largely accepted this difficulty rather than treating it as a central scientific challenge

www.thetransmitter.org/animal-model...

2 months ago 5 2 0 1
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Psychopharmacology Psychopharmacology is an international journal discussing the mechanisms by which drugs influence behavior. Publishes research and reviews on the impact of ...

The special issue in Psychopharmacology from EBPS2023 is now out as a complete collection. You can find the papers all here link.springer.com/journal/213/...

2 months ago 3 2 0 1
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If you had the choice of studying cocaine addiction in rats alone in a cage with only cocaine or at least one other substance, what would you do?

In this new interesting study, Nowak and her co-authors chose the second option.

link.springer.com/content/pdf/...

2 months ago 3 3 0 0
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#eNeuro Open Source Tools and Methods | A Common Iba1 Antibody Labels Vasopressin Neurons in Mice
https://doi.org/10.1523/ENEURO.0323-25.2025

2 months ago 1 1 0 0
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Very happy to share a new paper in
@npp-journal.bsky.social I thought I knew what would predict escalation of cocaine use. Well, I was wrong. After tracking behavior daily for weeks, the answer turned out to be the opposite of my prediction, and it changed how I see addiction.

2 months ago 22 10 1 0
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Breaking initial resistance to incentive salience with sufficient drug exposure

Individuals initially resistant to incentive salience can, with sufficient exposure, become sensitized and escalate cocaine use to the same level as more susceptible individuals

www.nature.com/articles/s41...

2 months ago 5 3 0 0
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Thoughts of an Ex-Editor - Psychopharmacology Psychopharmacology -

apropos of absolutely nothing, a lot of scientists could profit from reading this editorial from legendary Conan Kornetsky upon retiring from an editor position.
link.springer.com/article/10.1...

2 months ago 6 2 1 0
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EBPS2023 special issue: Stress, trauma and cannabinoids - Psychopharmacology Psychopharmacology -

What an undertaking this was. So proud of the collection @mayoonthebrain.bsky.social , @brainsbeesbikes.bsky.social , @cbaunez.bsky.social and I collected for the “Stress, Trauma and Cannabinoids” special issue in @psychopharmacology.bsky.social
Editorial: link.springer.com/article/10.1...

2 months ago 15 8 0 1
Tallie Z Baram speaks at UC Irvine

Tallie Z Baram speaks at UC Irvine

Thrilled to experience @talliezee.bsky.social’s @ucibiosci.bsky.social Dean’s Distinguished Lecture today @ucirvine.bsky.social!
@ucirvinemedschool.bsky.social

2 months ago 7 0 0 1
Highlighted Topics | Grants & Funding

On a call with NIH PO this morning - I knew NOSIs were no longer a thing, but wasn't aware they now have these "Highlighted Topics". Not clear how it exactly interfaces with funding and/or how you highlight alignment, but good to keep an eye on!

grants.nih.gov/funding/find...

2 months ago 15 9 3 0
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The U.S. Is Funding Fewer Grants in Every Area of Science and Medicine (Gift Article) A quiet policy change means the government is making fewer bets on long-term science.

www.nytimes.com/interactive/...

2 months ago 3 2 0 0
Redirecting

Hey ventral pallidum fans, see our new paper showing that #VP GABA neurons, known for reward, also regulate aversive motivation! Inhibiting these cells with #DREADDs potentiates active or passive defenses to threats, likely via LHb.
Congrats to Erica Ramirez & Marty Martinez!
doi.org/10.1016/j.yn...

2 months ago 21 7 1 0