APOE is a presynaptic protein that accumulates with age and modulates neurotransmitter release www.biorxiv.org/content/10.64898/2026.04...

El Gobierno acusa a Feijóo de “desconocimiento o mala fe” por decir que va a regularizar a “inmigrantes que han abusado de una mujer” eldiario.es/politica/ult...

Amancio Ortega, el mayor rentista del mundo Hoy, el oligarca español se ha convertido en la persona con mayor patrimonio inmobiliario del planeta. Sus rentas las ingresa en Luxemburgo para no pagar impuestos

Hoy, el oligarca Amancio Ortega se ha convertido en el mayor especulador del mundo. Es la persona con mayor patrimonio inmobiliario del planeta. Sus rentas las ingresa en Luxemburgo para no pagar impuestos. Un "patriota"

fonsiloaiza.substack.com/p/amancio-or...

"Light Fossils" dinosaur light painting by artist Darren Pearson, known as Darius Twin, using a unique photography technique.

The artwork is created using long-exposure photography, where the camera shutter remains open while the artist moves handheld lights to "draw" the figures in real-time.

CDC delays publishing report showing covid vaccine benefits The acting CDC director cited concerns with the methodology, but the design has long been used to test vaccine effectiveness.

Exclusive: The acting director of the CDC has delayed publication of a report showing the covid-19 vaccine cut the likelihood of ER visits and hospitalizations for healthy adults last winter by about half, according to two scientists.

Our sun eclipsed by the moon. The "dark side of the moon" and the "Earthset".

Amazing views from Artemis II and a change of perspectives.

_____
Credits: NASA

Welcome to RustQC Fast quality control tools for sequencing data, written in Rust.

Super excited to be launching two things today: #RustQC 🦀🧬 and rewrites.bio 🚀

I used AI to rewrite 15 RNA-seq QC tools into a single Rust binary (I've never written any Rust). It ended up being over 60x faster. Here's the story 🧵

seqeralabs.github.io/RustQC/

I Am Not a Number A memorial for the 60,199 Palestinian victims of the Israeli genocide in Gaza. Each dot is a name. Each name was a life.

Badr AlKhamissi ha creat un memorial per a les víctimes del genocidi comès contra el poble palestí, on cada punt lluminós representa un nom, i cada nom era una vida.

Més de 72.000 víctimes.

“I Am Not a Number” 👇🏾
bkhmsi.github.io/i-am-not-a-n...

According to Microsoft Copilot Terms of Use, updated in Oct. 2025, "Copilot is for entertainment purposes only" and "Don't rely on Copilot for important advice" (Jowi Morales/Tom's Hardware)

Main Link | Techmeme Permalink

Heads up GitHub users. You have less than a month left to opt out of "Allow GitHub to use my data for AI model training".

"On April 24 we'll start using GitHub Copilot interaction data for AI model training unless you opt out." github.com/settings/cop...

A view of Planet Earth in which the brown and green land is seen dotted amidst the blue sea. Some white whispy clouds roll across the hemispheres. The bottom right of the outline of earth is glowing from the light of the sun. The outline of the Orion window is faintly visible in the photo

PHOTO OF THE DAY: Perhaps of the greatest photos ever taken.

Captured by the crew of Artemis II this morning, looking at all of us through the window of the Orion capsule. The outline of the window is faintly visible in the photo.

Breathtaking.

(📸 NASA)

A full disc image of Earth, as seen from the Orion Crew Module. The planet is a pale blue, swirling with white clouds and glowing slightly lighter blue in place from reflected light. At lower left, a large brown landmass is Africa, with Spain and Portugal with twinkling lights where the planet curves. At top right, auroras glow in a thin green glow, just barely separated from the planet's surface. Earth is set against the black of space (pic: NASA/R.Wiseman)

More context on this #Artemis II image:

* This is the night side, lit by moonlight. You can see city lights in Spain & Portugal, & a sliver of day at lower right

* The Sun is entirely behind Earth, which makes it a kind of solar eclipse, but w/ Earth doing the eclipsing instead of the Moon:
☀️🌍🚀🌕

npj Complex.: Inequality of opportunities creates structural marginalization in networks
https://www.nature.com/articles/s44260-026-00077-z

💉 Com es crea una vacuna? Són totes iguals?

🧪 Divendres vam estar al Saló de l'Ensenyament explicant el procés de creació d’una vacuna.

🦠 Ho vam fer simulant un cas real: el de la vacuna del virus del Nil Occidental, un virus emergent que investiguem dins del projecte @lwnvivat.bsky.social.

Rethinking Depression — Hidden Brain We tend to see depression as an illness to eliminate, evidence that something has gone wrong in the brain. But what if low mood serves a purpose? Psychologist Jonathan Rottenberg examines the evolutio...

Podcast link: #depression
overcast.fm/+AA1WhMviJkI

Gigantesca manifestación hoy en la huelga de profesores catalanes contra el govern de Salvador Illa por mejoras laborales. Impresionante.

This has been up for a while but I haven’t really publicized it. Introducing ciMIST: sparse, self-consistent network models of local and global protein conformational entropy, learned from molecular dynamics. This helps with analyzing MD and connecting to experiments

www.biorxiv.org/content/10.1...

New OpenFold3 preview out! (OF3p2)

It closes the gap to AlphaFold3 for most modalities.

Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

'AI Is African Intelligence': The Workers Who Train AI Are Fighting Back Kenyan workers are still the underpaid labor behind AI training, moderation, and sex chatbots. The Data Labelers Association is fighting back.

Kenyan workers are still the underpaid labor behind AI training, moderation, and sex chatbots. The Data Labelers Association is fighting back.

'AI Is African Intelligence': The Workers Who Train AI Are Fighting Back Kenyan workers are still the underpaid labor behind AI training, moderation, and sex chatbots. The Data Labelers Association is fighting back.

Sama contracta amb Meta i OpenAI. Ha estat demandada repetidament per sous de misèria i l'estrès post traumàtic que han acabant desenvolupant molts dels seus treballadors. El sindicat no dubta en assenyalar aquestes pràctiques com a neocolonials.
www.404media.co/ai-is-africa...

ChatGPT as a cognitive crutch: Evidence from a randomized controlled trial on knowledge retention The rapid integration of generative artificial intelligence into higher education has outpaced empirical understanding of its effects on fundamental l…

"While AI assistance may ease initial learning, it appears to undermine the effortful processes needed for robust learning"

www.sciencedirect.com/science/arti...

Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202...

Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️

Lo MEJOR y lo PEOR de la semana en la que regresó Jason Tatum Comienza la temporada para los Boston Celtics.

Ya está en vuestras bandejas lo MEJOR y lo PEOR de la semana, con protagonismo principal de Jayson Tatum, la recta final de las negociaciones de la WNBA, y la última guerra judicial de los Dallas Mavericks.

www.nbaconcontexto.com/p/lo-mejor-y...

No es por principios morales, sino por no creer que la tecnologia es suficientemente precisa aun.

BREAKING:

The Justice Department just posted online three FBI interviews that had been missing from the massive trove of Epstein files initially released.

They're related to unsubstantiated sexual assault allegations against Donald Trump.

DOC 1: www.justice.gov/epstein/file...

This week's cover @thelancet.com

I'm constantly trying (/failing) to get this point across.

If you're a trained expert in a field, then it may be worthwhile to question the scientific consensus of your peers.

If you're not, the scientific consensus is absolutely the best you can do and it's arbitrary foolishness to disregard it.

New blog post:

"Higher orders need higher standards"

skewed.de/lab/posts/hi...

I discuss our current work disentangling misconceptions around "higher-order" networks: arxiv.org/abs/2602.16937

Explainer thread for the paper here: bsky.app/profile/tiag...

Los jóvenes encausados por la protesta contra Pilar Rahola que los Mossos ven "antisemita": "Banaliza el genocidio" La defensa de los investigados critica el sesgo de la policía catalana al considerar una motivación antijudía en el lanzamiento de pintura a la escritora ocurrido en 2024

Los jóvenes encausados por la protesta contra Pilar Rahola que los Mossos ven “antisemita”: “Banaliza el genocidio”