#medicalresearch #pain #arthritis | Teodora Trendafilova, PhD I am very happy to be advertising the position below for a post-doc to join me and Franziska Denk at King’s College London, Wolfson SPaRC (Sensory, Pain and Regeneration Centre). It’s a very exciting...

We are hiring! www.linkedin.com/posts/teodor...

Generously funded by the @sbohvm.gla.ac.uk Vet Fund. And comes out alongside a complementary preprint (www.biorxiv.org/content/10.6...). Two independent studies but coordinated to keep things aligned and transparent with a shared goal of building a useful resource for the field.

In situ hybridisation for various mRNAs in canine DRG tissue. Probes against GFRA2, KIT, IL31RA and SSTR2 are shown

Motivated by a simple question: how can studying pain biology in dogs help dogs, and also improve how we think about pain across species? We profile purified canine sensory neurons revealing conserved pain & itch biology across species, plus meaningful divergence with potential therapeutic relevance

New preprint out 🎉 Fantastic work from Paula, PhD student in the lab - great to finally see this one live. #PainResearch www.biorxiv.org/content/10.6...

A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...

Thrilled to share our latest preprint using single nuq sequencing and Xenium to define neuron organisation and sex differences in glia within human spinal cord. Truly a collaborative effort, with a big shoutout to Katherin Gabriel and @tedpricethepainguy.bsky.social

www.biorxiv.org/content/10.1...

Characterisation of cold-selective lamina I spinal projection neurons Skin cooling is detected by primary afferents that express the Trpm8 channel, but how this information is conveyed to the brain remains poorly understood. We have previously identified a population of...

www.biorxiv.org/content/10.1...

Labelled axons of calb1+ spinal projection neurons innervate multiple brain targets associated with cold sensation and thermoregulation. Darkfield images of different brain areas including the postal parabrachial and periaqueductal grey are shown with axons of ascending cells in yellow.

New preprint from the spinal cord group at Glasgow. Anatomical and functional characterisation of spinal circuits for cold, from sensory neurons to the brain…..www.biorxiv.org/content/10.1101/2025.10....

Are you interested in omics approaches to pain and projection neurons? Why not join us? We’ve got a post-doc position available. Happy to discuss further with anyone who is interested. www.jobs.gla.ac.uk/job/research...
#neuroskyence #neurosci #PainResearch

Check out my postdoc work at Ariel Levine’s lab, hot and fresh, describing how you build a dorsal horn!

www.biorxiv.org/content/10.1...

Here’s a great opportunity for someone…..

Cells of the mouse dorsal root ganglion. Cold sensing sensory neurons are small cells and are stained with HCR in situ hybridisation probes against TRPM8 mRNA

It's #fluorescencefriday so here are some lovely TRMP8-expressing cold-sensing sensory neurons in a mouse DRG. DAPI nuclei in green and TRPM8 mRNA in magenta.

1/ 🧠 Excited to share our new preprint:

Convergent state-control of endogenous opioid analgesia

We uncover how cognitive + contextual factors—like injury, fear, and placebo—modulate pain through dynamic opioid signaling in the periaqueductal gray (PAG)

biorxiv.org/content/10.1...

Hi Ted. Great idea. Could you add me please?

Anatomical characterisation of somatostatin-expressing neurons belonging to the anterolateral system Anterolateral system (ALS) spinal projection neurons are essential for pain perception. However, these cells are heterogeneous, and there has been extensive debate about the roles of ALS populations i...

Seems like a good idea to move over to here! What better way to start than our new preprint.... Anatomy of a fascinating molecularly defined subset of spinal projection neurons......
www.biorxiv.org/content/10.1...