Taurine from tumour niche drives glycolysis to promote leukaemogenesis - Nature The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.

new out in Nature www.nature.com/articles/s41...

We greatly appreciate input from the reviewers in helping us significantly improve our study, and @barbmarte.bsky.social for her help through the process.

Incredibly grateful to our many collaborators at @wilmotcancer.bsky.social John Ashton, Craig Jordan and Takashi Ito. This work would not have been possible without generous support from NCI, NIDDK, @ash.hematology.org and @leukemiaresearch.bsky.social

Using temporal scRNA-Seq of the bone marrow stromal niche, we develop a ligand-receptor map of signals promoting leukemia growth. We identify bone marrow osteolineage cells as a critical local source of taurine for leukemia cells. Explore our scRNA-Seq: wilmot-genomics.shinyapps.io/gse226644/

Powered by a team of amazing scientists in my lab @sonalish25.bsky.social, Ben Rodems, Cameron Baker and Christina Kaszuba, we find that loss of taurine uptake by Slc6a6 in leukemia cells impacts glycolysis and mTOR signaling to impair disease progression

Taurine from tumour niche drives glycolysis to promote leukaemogenesis - Nature The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.

Thrilled to share our work on the role of taurine in myeloid leukemia progression in @nature.com www.nature.com/articles/s41...

Thanks for making this Kellie! May I please be added? Thanks!