Ralph Neumüller (@ralphneumueller) Bsky

Thrilled to share our preprint uncovering a previously unrecognized mechanism in cancer biology driven by the cancer‑testis antigens MAGE‑A3 and -A6.
We identify BAP18 as a molecularly validated degradation target—revealing how MAGE‑A3/6 drives tumor progression.

www.biorxiv.org/content/10.6...

3 weeks ago 4 1 0 0

DUSP4 knockdown in BRAF V600E mutant colorectal cancer induces cell cycle arrest and halts tumor growth Oncogenic signaling in cancer cells is essential for proliferation, and its disruption, either through inhibition or overactivation, can provide therapeutic opportunities. Dual specificity phosphatase 4 (DUSP4), a negative regulator of the MAPK pathway that dephosphorylates ERK, has been proposed as a potential target; however, its therapeutic relevance has not been evaluated in vivo. In this study, we show that DUSP4 knock-down induces G1 cell cycle arrest and reduces proliferation in BRAFV600E-mutant and BRAF inhibitor-resistant colorectal cancer models, both in vitro and in vivo, and induces a rapid DUSP5-mediated adaptive response. While treatment achieved tumor stasis indicating disease control, it did not yield tumor regression, suggesting that DUSP4 may have limited efficacy as a monotherapy target in cancer. ### Competing Interest Statement All authors are full time employees at Boehringer Ingelheim RCV.

Our new preprint on DUSP4 in cancer is out. In vivo ARTi studies show DUSP4 loss doesn’t cause tumor regression and triggers fast compensatory reactivation. These results challenge DUSP4 as a monotherapy target. Link to preprint: www.biorxiv.org/content/10.6...

3 months ago 1 2 0 0

DUSP4 knockdown in BRAF V600E mutant colorectal cancer induces cell cycle arrest and halts tumor growth Oncogenic signaling in cancer cells is essential for proliferation, and its disruption, either through inhibition or overactivation, can provide therapeutic opportunities. Dual specificity phosphatase 4 (DUSP4), a negative regulator of the MAPK pathway that dephosphorylates ERK, has been proposed as a potential target; however, its therapeutic relevance has not been evaluated in vivo. In this study, we show that DUSP4 knock-down induces G1 cell cycle arrest and reduces proliferation in BRAFV600E-mutant and BRAF inhibitor-resistant colorectal cancer models, both in vitro and in vivo, and induces a rapid DUSP5-mediated adaptive response. While treatment achieved tumor stasis indicating disease control, it did not yield tumor regression, suggesting that DUSP4 may have limited efficacy as a monotherapy target in cancer. ### Competing Interest Statement All authors are full time employees at Boehringer Ingelheim RCV.

Our preprint on DUSP4 in cancer is out. In vivo ARTi studies show DUSP4 loss doesn’t cause tumor regression and triggers fast, DUSP5-mediated compensatory reactivation. These results challenge DUSP4 as a monotherapy target. Link to preprint: www.biorxiv.org/content/10.6...

3 months ago 1 0 0 0

Science-Fiction-Autor über KI: "Wir entscheiden selbst über Utopie oder Dystopie" Der Österreicher Ralph Neumüller räumt zum zweiten Mal in Folge den Deutschen Science-Fiction-Preis ab. Er will das Genre als gesellschaftliches Experimentierfeld sichtbarer machen

Science-Fiction-Autor über KI: "Wir entscheiden selbst über Utopie oder Dystopie"
www.derstandard.at/story/310000...

6 months ago 1 0 0 0

Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research | News | The Harvard Crimson FlyBase lost a multimillion dollar grant when the Trump administration cut off Harvard’s federal funding in May. Now the repository is laying off staff — and researchers worldwide are worried.

www.thecrimson.com/article/2025...
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research

7 months ago 19 25 0 0

Die wichtigste Datenbank über die Fruchtfliege steht vor dem Aus. Forscher weltweit sind auf eine zentrale Datenbank mit Erkenntnissen zu Drosophila angewiesen. Deren Finanzierung steht vor dem Aus. Wegen Donald Trump. Warum uns das nicht gleichgültig sein sollte.

Thanks to journalist @felixschmidtner.bsky.social for bringing the plight of the key scientific database @flybase.bsky.social to a German/European audience
www.faz.net/aktuell/wiss...

7 months ago 16 9 1 1

FlyBase:Contribute to FlyBase - FlyBase Wiki

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

8 months ago 130 159 3 26

ICYMI last year in Cancer Discovery @aacrjournals.bsky.social: Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-driven Cancers – by Birgit Wilding, Ralph Neumüller, et al. doi.org/10.1158/2159...

8 months ago 3 2 0 0

Novel carbodiimide warheads for aspartate covalent targeting. The field marches on. pubs.acs.org/doi/abs/10.1...

11 months ago 2 1 0 0

Ich würde tatsächlich vermuten, dass hauptsächlich mit LLMs geantwortet wird und danach KI alles analysiert 😂.

1 year ago 0 0 0 0

Genau in einer Woche, 23.02. ab 14h, sind wir wieder im @radioorange940.bsky.social Studio und freuen uns über Eure Anrufe! Zu Gast ist @ralphneumueller.bsky.social dessen Roman "Das Stoffuniversum" wir besprechen. Es geht um Viele Welten, Einsamkeit und Chemie.
Lest mit & ruft an!
#sciencefiction

1 year ago 11 3 0 1

indiecharts - Singles Österreichs wöchentliche Independent-Charts, gevotet von den österreichischen Indie-DJs

Der Soundtrack zu meinem Roman "Das zweigeteilte All" ist Nummer 1 der Österreichischen Indie Charts. Danke an Kommando Elefant 🤩

indiecharts.at

1 year ago 0 0 0 0

Könnte aus dem Terminator sein :-)

1 year ago 0 0 0 0

Ralph Alexander Neumüller (13.02.2025) Literatopia - eure Welt der Literatur! Rezensionen, Forum, Interviews, Events und vieles mehr ...

Vielen Dank an die großartigen @literatopia.bsky.social für das Interview. Ich freue mich sehr, dass ich dabei sein durfte. www.literatopia.de/index.php?op...

1 year ago 3 2 0 0

Kommando Elefant ft. Ralph Alexander Neumüller - Traurige Maschinen YouTube video by kommandoelefant

Er ist da!! Der Soundtrack zu meinem neuen Roman "Das zweigeteilte All":

"Traurige Maschinen" von Kommando Elefant.

Check out the Video. Wie im Buch stehen Mensch-Maschine Interaktion im Fokus.😉

www.youtube.com/watch?v=tFC4...

1 year ago 2 0 0 0

Ich freu mich sehr darauf. Ein großartiger Science-Fiction Buchclub auf Radio Orange!🤩

1 year ago 1 0 0 0

Im nächsten Superscience Me Radio-Lesekreis wird "Das Stoffuniversum von @ralphneumueller.bsky.social besprochen.
Buch besorgen, lesen, Radio einschalten, anrufen, mitreden
⬇️⬇️

1 year ago 4 2 0 0

Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers Zongertinib, a covalent HER2 inhibitor, is active in HER2-driven preclinical models and patients and effectively targets HER2 oncogenic signaling while sparing wild-type EGFR, resulting in potent inhi...

Excited to see our paper in print in Cancer Discovery @theaacr.bsky.social
@elizsmckenna.bsky.social
aacrjournals.org/cancerdiscov...

1 year ago 9 3 0 0

Posts by Ralph Neumüller