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Posts by Randy McIntosh

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Claude Code's Source: 3,167-Line Function, Regex Sentiment Anthropic claimed 100% of Claude Code is AI-written. A source leak exposed a 3,167-line function, regex sentiment analysis, and 250K wasted API calls daily

"AI amplifies whatever is already there. Good discipline becomes great output. No discipline becomes technical debt at machine speed. Anthropic chose a direction. Go faster. Have Claude check Claude. And when it breaks, go faster still." substack.com/home/post/p-...

1 day ago 22 10 2 0

> The controversy associated with the statement “Ada Lovelace was the first computer programmer” reveals more about modern attitudes towards women [than her] achievements. [Her 1843 algorithm] was so advanced, that it was still utilised in record-breaking computation of Bernoulli numbers in 2008.

2 days ago 427 148 10 4
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Hey friends🫂🫂

Let me remind you:
I have a YouTube channel now.

I didn’t plan to start it during the war.
But here I am.

I’ve been posting new videos lately -
About life in Ukraine, Donbas,
And what TV will never show you about this war.

🎥 Watch here:
youtube.com/@angelica.sh...

2 days ago 77 9 4 0
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Middle East crisis live: Trump leaves Situation Room to golf as ships report attacks and Iran closes strait of Hormuz Unicef pulls out of north Gaza Strip after fatal attack on contractors, and UN peacekeeper killed in Lebanon

“Middle East crisis live: Trump leaves Situation Room to golf as ships report attacks and Iran closes strait of Hormuz” www.theguardian.com/world/live/2... - @theguardian.com

#Iran #IranWar #MiddleEast #StraitofHormuz #USPoli

2 days ago 5 6 2 0
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🧠 Meet Dr. Milan Valyear (@milanium.bsky.social), the new Assistant Professor in @psych.ubc.ca and a researcher at the Djavad Mowafaghian Centre for Brain Health!

Learn more about his career journey and his research into brain circuitry: https://bit.ly/4szI4fT

4 days ago 9 5 0 0

“This is kind of an ideal to aim for,” @macshine.bsky.social says. “If someone criticizes your work, you don’t take it personally. You try to understand, in the most generous way possible, where they’re coming from and why they’d be worried about the problem.”
Amen to that 🙏

4 days ago 7 1 1 0
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Submission Guidelines | Join the Conversation Now — Disability Culture Lab Discover submission guidelines for Disability Culture Currents, an outlet for disabled voices exploring intersectionality, oppression, and disability culture through essays, comics, and art.

Publication looking for writing submissions from disabled authors

5 days ago 6 5 2 0
The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

The supply of blood to brain tissue is thought to depend on the overall neural activity in that tissue, and this dependence is thought to differ across brain regions and across brain states. However, studies supporting these views have measured neural activity as a bulk quantity and related it to blood supply following disparate events in different regions. Here we measure fluctuations in neuronal activity and blood volume across the mouse brain, and find that their relationship is consistent across brain states and brain regions but differs in two opposing brainwide neural populations. Functional ultrasound imaging (fUSI) revealed that whisking, a marker of arousal, is associated with brainwide fluctuations in blood volume. Simultaneous fUSI and Neuropixels recordings showed that neurons that increase activity with whisking have distinct haemodynamic response functions compared with those that decrease activity. Their summed contributions predicted blood volume across states.Brainwide Neuropixels recordings revealed that these opposing populations coexist in the entire brain. Their differing contributions to blood volume largely explain the apparent differences in blood volume fluctuations across regions. The mouse brain thus contains two neural populations with opposite relations to brain state and distinct relationships to blood supply, which together account for brainwide fluctuations in blood volume.

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states!

Out today in Nature: rdcu.be/fdC2A

@uclbrainscience.bsky.social

6 days ago 143 62 4 6
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We’re about to hear a lot of hand-wringing about how the internet did this to men but this is what men did to the internet.

5 days ago 206 100 5 2
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a bear is behind a wire fence looking up ALT: a bear is behind a wire fence looking up

I'm here!!

5 days ago 1 0 1 0

I had a grumpy uncle moment with my students yesterday. I told them about the freedom summer when activist were beaten and killed as they tried to register Black folks to vote. One student said, well the number weren’t that bad. I went into a lecture about taking their opportunities for granted.

5 days ago 35 3 3 1

[shocked pikachu.jpeg]

5 days ago 11749 2522 188 65
Driftwood Brewing Son of the Morning Golden Ale can, poured into a glass - afternoon sun reflecting of a white stone counter. Demon character on a can - 10% alcohol! Eek.

Driftwood Brewing Son of the Morning Golden Ale can, poured into a glass - afternoon sun reflecting of a white stone counter. Demon character on a can - 10% alcohol! Eek.

Burrard inlet in Port Moody at low tide.  Water receding with fog lifting in the background and majestic clouds behind Burnaby Mountain.

Burrard inlet in Port Moody at low tide. Water receding with fog lifting in the background and majestic clouds behind Burnaby Mountain.

A little mid-week treat for myself - a good day with a lovely run in the sun, end of term grading done, and a successful Master's thesis defence for our team member Anis Zahedifard. 🎉
#CraftBeer
Cheers, y'all. 🍻🙏

5 days ago 6 0 0 0
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Join Dr. Angelina Polsinelli as she explores how research initiatives are improving the detection and understanding of Atypical Alzheimer’s Disease Variants.

Thursday, April 23rd
2:30 PM (PDT)
SFU Burnaby Campus + online

For more information: www.sfu.ca/neuro-instit...

1 week ago 0 1 0 0
White matter pathways mediating dorsolateral prefrontal TMS therapy for depression - Nature Neuroscience Seguin et al. show that the efficacy of transcranial magnetic stimulation for depression depends on how stimulation spreads through the brain’s wiring. Patients with shorter communication pathways bet...

White matter pathways mediating dorsolateral prefrontal TMS therapy for depression

New @natneuro.nature.com paper led by Caio Seguin, Robin Cash, and Andrew Zalesky.

We map (indirect) pathways from DLPFC to SGC and link individual variation with response efficacy.

www.nature.com/articles/s41...

1 week ago 23 11 1 0
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Driving in Circles "I remember when we were driving, driving in your car."

I am doing a limited, local tour for THE LAST AMERICAN ROAD TRIP. The first event is April 15 in St Louis at the University City Public Library, 7-8:30 PM. The second is April 18 at 10:45 AM at the Unbound Book Festival in Columbia, MO.

Links/info here: sarahkendzior.substack.com/p/driving-in...

1 week ago 101 24 8 4
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Neural circuits encode prior knowledge of temporal statistics - Nature Neuroscience This study shows that cerebellar circuits learn and encode prior probabilities of event timing. Cell-type-specific neural activity reflects environmental statistics and guides predictive motor behavio...

Our work on how neural circuits in the cerebellum encode prior probabilities led by Julius Koppen is out now in Nature Neuroscience www.nature.com/articles/s41...

Big thanks to Julius Koppen & the whole team! And dedicated to all of us who found inspiration in Bayesian theories of the brain!

1 week ago 61 25 1 1

Thanks, Natalie. Though the credit really goes to the team, especially Jack Solomon, who really pulled this through.

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This is our latest work, validating initial observations we made with multiscale entropy and EEG and extending them with a larger sample size to show sex-dependent differences across age. Thanks to @camcan-2010.bsky.social for access to the data. cc @rhens.bsky.social

1 week ago 11 4 1 0

Amazing that you have the same glasses!

1 week ago 2 0 1 0
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Missed our NeuroAI workshop?

Watch the full recording on YouTube led by Dr. Angelica Lim @petitegeek.bsky.social and Payam Jome Yazdian from Simon Fraser University.

Watch the full recording on YouTube: youtu.be/E6N0u4iCJ4c

#NeuroAI #ArtificialIntelligence #Neuroscience #Research #SFU

1 week ago 4 4 0 0
black and blue ink painting of black hole with grid

black and blue ink painting of black hole with grid

Hey, I made some more #sciart! New Black Hole ink painting on yupo artologica.etsy.com/listing/4486...

1 week ago 168 46 4 1

Very cool - thanks for posting. 🙏

1 week ago 1 0 0 0
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A star scientist showed that better genetics lessons could reduce racism. It was the death knell for his career Brian Donovan had persuaded high school teachers and education researchers that prejudice might be ended by changing how genetics is taught.

Read this. this is what the administration wants to happen. this is how they destroy science... www.statnews.com/2026/04/07/b...

2 weeks ago 20 9 1 2
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Register soon! Consider becoming a member:
Check upcoming events here:
philandneuro.wildapricot.org
Recordings also available for members.

Seminars by @lucinauddin.bsky.social @avramholmes.bsky.social @martinhebart.bsky.social , Ralph Adolphs, and I.
Second round of seminars being planned for fall

2 weeks ago 14 5 0 1

Hey! NeuroAI types and beyond - bookmark this one 👇

2 weeks ago 2 1 1 0
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Promo your stuff relentlessly, before, during, years after release. This is probably because I was a stand up and we necessarily lived in self-promotion mode, but if I
don’t see you posting about your shit every day, I assume
the weird American Calvinist kind virus got you. Or you’re Canadian.

2 weeks ago 419 103 20 14

This is the most delightful thing I’ve ever read

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This editorial discusses the critical value of human-generated scientific writing in the era of large language models (LLMs), arguing that writing is essential to structured thinking and research comprehension. 
Writing as Thinking: The act of writing structure's thoughts, sorting research data, and identifying the main message, unlike LLMs which may lack true understanding or accountability.
LLM Hallucinations: LLM-generated text requires rigorous verification because these models can produce incorrect information or fake references.
Human vs. AI Roles: While LLMs are useful tools for brainstorming, improving grammar, or overcoming writer's block, human researchers must maintain control to engage in the creative task of shaping a compelling narrative.

This editorial discusses the critical value of human-generated scientific writing in the era of large language models (LLMs), arguing that writing is essential to structured thinking and research comprehension. Writing as Thinking: The act of writing structure's thoughts, sorting research data, and identifying the main message, unlike LLMs which may lack true understanding or accountability. LLM Hallucinations: LLM-generated text requires rigorous verification because these models can produce incorrect information or fake references. Human vs. AI Roles: While LLMs are useful tools for brainstorming, improving grammar, or overcoming writer's block, human researchers must maintain control to engage in the creative task of shaping a compelling narrative.

Writing forces your brain to coordinate memory, reasoning, and meaning-making simultaneously.

Every time you write, you rewire toward clearer thinking. Every time you let an LLM do it, you rewire toward consumption.

2 months ago 211 82 5 7

🚨 The FY2027 budget dropped today. Scientists, do not make the same mistake as last year.

Last year, the 40% NIH cut was never real. Congress rejected it. Everyone exhaled.

Meanwhile the admin executed RIFs, grant freezes, NOFO collapse, & terminated grants without Congress.

The relief was a trap

2 weeks ago 6 1 1 0