Evolution of ion channels in the water-to-land transition of vertebrates www.biorxiv.org/content/10.64898/2026.04...

fireborn.mataroa.blog/blog/the-slo...

Structural Conservation, Functional Decline: The Fate of Human OHCU Decarboxylase The conversion of uric acid to (S)-allantoin is catalyzed by urate oxidase (uricase), 5-hydroxyisourate hydrolase (HIUase), and 2-oxo-4-hydroxy-4-carb…

Acabou de sair: nosso artigo com o grupo da Mariana sobre a OHCU decarboxilase, a terceira enzima da nossa via metabolica preferida.

Just out: our article with Quezado's group about the OHCU decarboxylase, third enzyme in our favorite metabolic pathway
www.sciencedirect.com/science/arti...

We built DNA scaffold crystals that can be reprogrammed to host different guest proteins for X-ray structure determination — no new crystallization screen required. This animation shows a guest protein (glowing) seeking its designed binding site inside the crystal lattice. shorturl.at/DANdc

Pois é, a impressão que sempre me deu é que, se houvesse a oportunidade, fariam PPP.

Mas na área de desenvolvimento de fármacos isso é raríssimo, não? Eu convivo com o pessoal dessa área desde os anos 2000 e quase sempre vejo o contrário.

grupo onde eu tava em que perguntaram como fazer para colaborar com eles e ele basicamente respondeu que seria quando tivesse quase um produto pronto. Aí fica difícil mesmo passar da pesquisa básica pro fármaco. Ao contrário do que diz o lugar comum, o setor privado não gosta de correr risco.

Aí eu vou discordar um pouco, essa "resistência" dentro da academia está longe de ser o maior motivo disso não acontecer, muito maior é a resistência do próprio setor privado, que não tem interesse em desenvolvimento. Lembro duma palestra de um representante de uma farmacêutica há uns 20 anos no (+)

Mosquitoes like Aedes aegypti spread viruses that cause major global diseases. We decided to have a closer look at a family of mosquito carbohydrate-binding proteins involved in infecting these vector species. We found some unexpected things 😁

Preprint out now 🦟🦟🦟

www.biorxiv.org/content/10.6...

Lendo esse livro aqui sobre a alma mater e estou achando excelente!

editora.ufc.br/pt/catalogo/...

The media should be PRAISING these athletes who know and understand the importance of public health. These articles should be about how they are setting an example for EVERYONE. And how we should all take their lead.

Instead their positioning is: “look at these fucking weirdos”

Check out our new review in Nature Reviews Genetics on de novo emerged genes and proteins. How they emerge, are lost and persist - and how de novo emerged proteins relate to randomized proteins! @bornberglab.bsky.social www.nature.com/articles/s41...

Our lab will be boycotting biotech vendors that have contracts with ICE (e.g., Fisher, Agilent), and telling them why. If you google “vendorname usa spending”, you can see purchases for specific depts including ICE on usaspending.gov. Please talk to your labs and email your vendors!

Já recebi *várias vezes* convites para publicar numa chamada "Journal of Rice Science" e em outra de ginecologia e obstetrícia. Minha área não tem absolutamente nada a ver com nenhuma das duas, aliás.

Aí pensei que poderia escrever sobre vontade de comer arroz na gravidez e mandar logo pras duas.

The NIH has lost its scientific integrity. So we left “We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.

This is so incredibly heart-breaking. To Jay Bhattacharya and Matthew Memoli at NIH--you have betrayed the entire scientific community. Deeply committed staff are leaving in droves--because you are destroying the institution. Shame on you. www.statnews.com/2026/01/10/n...

Examples of crystals

Interested in crystallizing your favorite biomolecule for structural studies?
Join the #IUCr2026 Biomolecular Crystallization Workshop for
- Sample prep/characterization
- Optimization and seeding
- Ways to ‘see’ your crystals
- Ultrasmall to large crystals
- AI/ML advances
event.fourwaves.com/...

Mammals have evolved into ant eaters 12 times since the dinosaur age, study finds Mammals have developed some unusual eating habits over the past 100 million years, but a new study has uncovered the surprising lengths to which some have gone to satisfy one of the more peculiar—a ta...

Tired: Everything evolves to be a crab.

Wired: Everything evolves to eat ants.

Journal of Molecular Evolution Publish your work in a journal known for classic papers from Ohta, Felsenstein, and Zuckerkandl! Journal of Molecular Evolution focuses on deciphering ...

Mais uma edição da Journal of Molecular Evolution que eu queria ter em versão impressa pra ler com calma. Esse número é uma edição especial sobre ortólogos.

link.springer.com/journal/239/...

Amplificando DNAs e bobagens Saber muito sobre algo não significa saber algo sobre tudo

Newsletter nova falando sobre alternativas ao Papanicolau e bobagens de quem ganhou o Nobel.

literaturaqueijof1.substack.com/p/amplifican...

Esse congresso já foi um sucesso estrondoso na primeira edição (em que foi necessário antecipar o encerramento das inscrições ou o local não ia comportar o evento - foram mais de 700 inscritos!), e o próximo, aqui em Belo Horizonte, tem tudo pra ser excelente também!

Great news!
JSTOR now have a free account with an Independent Researcher category. You can access 100 documents per month

www.jstor.org/action/showL...

The simple machine that visualised atomic orbitals In 1931, Harvey Elliott White developed a device that traced out the shapes of electron clouds by approximating solutions to the Schrödinger equation

In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com
www.chemistryworld.com/opinion/the-...

I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.

PDB101: Searching the PDB for High-Quality Ligand-Bound Structures PDB-101: Training, Outreach, and Education portal of RCSB PDB

Watch the Webinar: Searching the PDB for high-quality ligand-bound structures
Learn how to search the PDB for the best examples of ligands using text, chemical drawing, and APIs

Evolution meets biophysics in the early history of transthyretins Transthyretin, the primary thyroxine carrier in the cerebrospinal fluid, has been known since the forties, but the discovery of homologs in C. elegans and several microorganisms in 2000 revealed an in...

After our study on transthyretin and HIUase ancestral reconstruction, I wrote this personal account on how TTRs were present in key moments in my career and on tackling this interesting case of neofunctionalization using crystallography and calorimetry

communities.springernature.com/posts/evolut...

imigração é um direito. fronteiras são inventadas. bichos migram, os seres humanos sempre mudaram de lugar.

The title of my keynote will be "The critical use of Degenerative AI in Doctoral education" 🔥 | Dagmar Monett The title of my keynote will be "The critical use of Degenerative AI in Doctoral education" 🔥

(The title of my keynote will be "The critical use of Degenerative AI in Doctoral education" 🔥)

www.linkedin.com/posts/monett...

Very interesting recollection from interviews and the literature on alchemical free-energy methods.

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"THE DAWN OF ALCHEMICAL FREE-ENERGY METHODS IN BIOMOLECULAR SIMULATIONS" (Daniele Macuglia, Giovanni Ciccotti, Benoît Roux)
arxiv.org/pdf/2510.04917

Journal of Molecular Evolution tem artigos tão maravilhosos que fico triste que não exista mais versão impressa, queria tirar um dia por mês pra ir numa biblioteca e ler a última edição.

PDB101: Learn: Other Resources: Bound! Protein-drug matching game Bound! is a card game for students 12 and up, where players compete to match the most drugs to their protein targets.

Players match protein targets with drugs in this game developed by RCSB PDB and @ccdc.cam.ac.uk