📣 For our next CCMN seminar, we are pleased to welcome Dr. Hannah Botfield from the University of Birmingham, who will be presenting on:

🧠 Modulating CSF dynamics for stroke and hydrocephalus therapy

📅 Wednesday 22nd April
⏰ 1:00 PM
📍 CABI Seminar Room, Paul O’Gorman Building

The critical role of gut–brain signalling in eating behaviour and obesity Nature Reviews Gastroenterology & Hepatology, Published online: 21 April 2026; doi:10.1038/s41575-026-01203-xThis Review outlines the role of gut–brain signalling in eating behaviour and obesity, highlighting gut-derived signals and cues relevant during eating phases. Underlying mechanisms of this gut–brain communication are discussed alongside the key role of the vagus nerve in this process.

New online! The critical role of gut–brain signalling in eating behaviour and obesity

The critical role of gut–brain signalling in eating behaviour and obesity - Nature Reviews Gastroenterology & Hepatology This Review outlines the role of gut–brain signalling in eating behaviour and obesity, highlighting gut-derived signals and cues relevant during eating phases. Underlying mechanisms of this gut–brain ...

Really pleased to share our review of evidence for the diverse roles of the #vagus in each phase of eating behaviour, and our thoughts on how dysfunctional vagal #interoception drives obesity pathogenesis.

Hope it provokes some thoughts, and many experiments!

🧠📈 🧪

www.nature.com/articles/s41...

👇 Great advice! 👇

📣 New paper out from @trapp-lab.bsky.social led by @wanqingjiang.bsky.social. Big congratulations to all authors!

The CCMN Lecture Series is back! 🔬✨

We are excited to welcome Monica Imbernon from Queen Mary University of London,who will be speaking on:

🧠 ‘The involvement of the circumventricular organs in energy homeostasis’

📅 Wednesday 18th March
⏰ 2:00 PM
📍 Medical Sciences 131 A V Hill Lecture Theatre

The CCMN Photography Enthusiasts had their 10th annual competition last night with lots of brilliant entries. Congratulations to this year's winner: Alex Gourine!

Happy Holiday Season to all friends, colleagues, collaborators and competitors! May the GLP-1 field stay as exciting in 2026 as it was in 2025!

📣 New preprint out from the Trapp lab!

Brain-Derived GLP-1—Understanding the Physiological Function and Anti-obesity Potential of Preproglucagon Neurons Abstract. Glucagon-like peptide-1 (GLP-1) is produced within the central nervous system (CNS) by preproglucagon (PPG) neurons. This brain-derived GLP-1, ra

📣 New review out from @trapp-lab.bsky.social!

Read to learn about the physiology and anti-obesity potential of preproglucagon neurons 🧠

Link here:
academic.oup.com/endo/article...

Thanks to @theiups.bsky.social 2025 meeting for a great Vascular Health and Function session where I was pleased to share exciting new data!

Dr Cecilia Skoug presenting the latest mouse behaviour data from the Trapp lab at @theiups.bsky.social. Great presence from @ccmnlondon.bsky.social at a fantastic meeting!

Another day, another excellent talk from a @ccmnlondon.bsky.social member. Dr. Anna Robert’s from @adriaenssenslab.bsky.social lab presented her work on GIP and vascular health here at @theiups.bsky.social 2025 meeting in Frankfurt.

More @ccmnlondon.bsky.social representation at #IUPS2025; Philippa Wittenberg, PhD student in Prof. Alex Gourine’s group presented her work on the baroreceptor mechanism.

Last conference for the year for me is IUPS 2025. Yesterday was the well-attended symposium ”GLP-1 Receptor Agonists - a Magic Bullet Beyond Diabetes and Obesity?” Chaired by Prof. Stefan Trapp @trapp-lab.bsky.social Maybe I’m
biased but a great symposium indeed! @ccmnlondon.bsky.social

Proud PI moment #1:

@phoebeclax.bsky.social doing a stellar job in her first ever conference poster session, presenting data generated during her @bsneuroendo.bsky.social funded undergraduate summer lab experience project.

#BSNBradford2025

Proud PI moment #2:

Superstar postdoc @laurenjonesucl.bsky.social absolutely smashing her first conference presentation of her fascinating data on #semaglutide mechanism of action.

#BSNBradford2025

Pleased to share a new paper that I'm proud to have contributed to 🌟 Grateful for the chance to work with such a talented team 🙌

Really enjoyed working on this - big thanks to everyone involved!

Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain - Nature Metabolism A series of fluorescent probes is designed that act as dual agonists on both GLP1 and GIP receptors, and are used to image receptor binding activities in tissues and animals.

Interested in brain access for Tirzepatide-based drugs? Have a look at the fluorescent Tirzepatide analogue developed by Johannes Broichhagen and David Hodson @daveyboyhod.bsky.social‬ out now in Nature Metabolism www.nature.com/articles/s42.... Proud to contribute to this great multi-lab effort.

📣 New paper out exploring brain access of Tirzepatide based fluorescent analogues! We are proud to have contributed to this multi-lab effort.

Unbelievably proud of @nataliefigueredob.bsky.social for winning the prestigious Bogue Fellowship 🌟 She'll be heading across the pond to train with the @zknight.bsky.social lab for 3 months. Exciting things to come for this bright young scientist 🧠. @uclnpp.bsky.social @ccmnlondon.bsky.social

Targeting GLP-1 in the brain could transform obesity care Explore the role of GLP-1 in regulating hunger and appetite, uncovering its complex mechanisms in the brain and gut.

Can targeting GLP-1 in the brain revolutionise obesity treatment? 🧠💉

Check out Professor Stefan Trapp’s take on how central GLP-1 pathways could transform the future of obesity care.

www.drugtargetreview.com/article/1606...

Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity - Nature Reviews Cardiology The physiological phenomenon whereby heart rate varies in phase with breathing in vertebrates has been known as ‘respiratory sinus arrhythmia’. In this Expert Recommendation, the authors argue that th...

📣 New publication alert!

“Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity” is now out!

Read the full article here:

www.nature.com/articles/s41...

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice - Nature Metabolism This study, together with a companion manuscript, show that, in mice, weight loss as a result of GIP receptor antagonism requires, and potentiates, functional GLP-1 receptor signalling in the brain, e...

It's a big week for GIPR pharmacology! Two great studies out in @natmetabolism.nature.com from Gutgesell et al (www.nature.com/articles/s42...) and Liu et al (www.nature.com/articles/s42...) revealing divergent neural mechanisms engaged by GIPR agonism vs antagonism. Commentary here: rdcu.be/ejPSA

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

We are recruiting! If you are interested in working as a post-doctoral Research Fellow in the heart of London contributing to MRC-funded research into GLP-1 action within the brain, please look at this link and apply if interested: www.ucl.ac.uk/work-at-ucl/...

UCL – University College London UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

www.ucl.ac.uk/work-at-ucl/...

📣Join the Trapp lab as a Postdoctoral Research Fellow!

The Trapp lab is seeking for a highly motivated Research Fellow to explore the role of GLP-1 action within the brain. If you are interested we encourage you to apply!

📍 Location: UCL, London
📆 Application deadline: March 19th