A collaboration between Monash Translational Medicine, Alfred Hospital, Monash Health, Burnet Institute, BD and Erasmus MC. Funded by Allergy and Immunology Foundation of Australasia, Jeffrey Modell Foundation and the Medical Research Future Fund PROPHECY grant.
This also supports the ATAGI decision for a three dose primary vaccination regimen, and reinforces the need for ongoing boosters in this high-risk population.
#inbornerrorsofimmunity #primaryimmunodeficiency #vaccineefficacy
Excited to share our work showing that patients with inborn errors of immunity generate immune memory after COVID-19 vaccination, even when neutralizing antibodies are absent. This challenges how we measure vaccine success, & the need to look beyond antibodies.
authors.elsevier.com/a/1mwz8Ks2xP...
Excited to share our work showing that patients with inborn errors of immunity generate immune memory after COVID-19 vaccination, even when neutralizing antibodies are absent. This challenges how we measure vaccine success, & the need to look beyond antibodies.
authors.elsevier.com/a/1mwz8Ks2xP...
Congrats Todd & team @bruskolab.bsky.social
Large-scale TCR repertoire profiling from peripheral blood reveals type 1 diabetes signatures linked to high-risk HLA alleles
www.science.org/doi/10.1126/...
Congratulations @mileshorton.bsky.social
Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammation @natcomms.nature.com
www.nature.com/articles/s41...
I know the feeling. Enraged and consoled sums my feelings up too.
One mechanism is Ddx3x support of Brwd1 expression at pre B cell stage and support of efficient cell cycle arrest as well as light chain rearrangement (resulting in skewed kappa/lambda usage)
We are all mosaics: vast genetic diversity found between cells in a single person @nature.com
www.nature.com/articles/d41...
@biorxivpreprint.bsky.social @mayoclinic.org @harvardmed.bsky.social @timcoorens.bsky.social @emblebi.bsky.social
www.biorxiv.org/content/10.1...
Single-Cell Multi-Omics Dissects Transcript Isoform and Immune Repertoire Dynamics in Human Immunosenescence www.biorxiv.org/content/10.1101/2025.11....
A PIK3delta inhibitor for ALPS:
Leniolisib reduced lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome url: rupress.org/jhi/article/...
Data-driven forecasting of Flu, RSV, and COVID-19 related outcomes in the United States and Canada via Hankel dynamic mode decomposition www.medrxiv.org/content/10.1101/2025.11....
Predicting long-term waning of anti-spike antibody-dependent protection against COVID-19 across diverse SARS-CoV-2 immune histories www.medrxiv.org/content/10.1101/2025.11....
Circulating biomarkers of bronchoalveolar injury help predict the need for mechanical ventilation in patients with moderate to severe COVID-19 pneumonia: a prospective cohort study www.medrxiv.org/content/10.1101/2025.11....
@jengommerman.bsky.social lab investigate an animal model of progressive #MultipleSclerosis & uncover a population of anti-CD20–resistant dural B cells that remain in the brain parenchyma at disease remission rupress.org/jem/article/...
📘 In #Neuroscience 2025: rupress.org/jem/collecti...
#SfN25
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
@medrxivpreprint.bsky.social @biorxiv-medrxiv.bsky.social
Proud to share our new preprint revealing how patients with inborn errors of immunity respond to 3 doses of COVID-19 vaccination. A fantastic collaboration between clinicians & scientists.
Monash University, Alfred Health, Monash Health, Burnet Institute, BD, Erasmus MC
medrxiv.org/cgi/content/...
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes @science.org @shaleklab.bsky.social
www.science.org/doi/10.1126/...
I’m excited to share our newly published paper. Only the second report of Spleen Tyrosine Kinase (SYK) gain-of-function. We detail the clinical, immunological, and genetic features of an adult with primary immunodeficiency and autoinflammation in the Journal of Clinical Immunology:
🔗 rdcu.be/eLWFr
Proud to be talking at this webinar on the 8th of October alongside Ig therapy manufacturers, patients receiving therapy, clinicians and SCIg nurses.
#patientawareness
Genetic regulation of cell type–specific chromatin accessibility shapes immune function and disease risk @medrxivpreprint.bsky.social @anglixue.bsky.social @drjosephpowell.bsky.social
www.medrxiv.org/content/10.1...
Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications www.biorxiv.org/content/10.1101/2025.08....
From lab bench to Parliament House, a few weeks ago, I was proud to bring the voices of patient advocacy and rare disease research to advocate for equitable and fair access to vaccination and blood products.
With this dual lens, I added evidence-based insights to strengthen the case for change.
Amazing new paper from @krishaurum.bsky.social and colleagues, designing novel pMHC-binders (synthetic TCRs) in silico: www.science.org/doi/10.1126/...
Scalable screening of ternary-code DNA methylation dynamics associated with human traits
www.cell.com/cell-genomic...
Differences in immune cell profiles around the time of islet autoimmunity seroconversion in children with and without type 1 diabetes www.biorxiv.org/content/10.1101/2025.06....
An excellent preprint offering valuable insights into the impact of CMV infection on the immune system. Three insights are important as CMV is a herpesvirus, to which over 70% of the population has been exposed.
